Biomarkers in Early Diagnosis and Early Stage Lung Cancer: The Clinician’s Point of View

Gasparri, Roberto; Sedda, Giulia

doi:10.3390/jcm9061790

Cited by 4 publications

(3 citation statements)

References 71 publications

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“…Autofluorescence imaging bronchoscopy (AFI) in lung cancer is used in Endobronchial lesions and narrow-band imaging bronchoscopy (NBI) is used to evaluate the diagnosis of premalignant airway lesions in the mucosal and submucosal vascular system [12,13,21]. Low-dose thorax CT (LDCT) screening for early diagnosis of lung cancer for heavy smoking, an increase in diagnosis has been observed [22]. For early-stage non-small cell lung cancer with peripheral blood samples, a concept analysis in 182 patients was evaluated in microRNA when miR-126-3p in disease-free survival and overall survival were statistically significant.…”

Section: Resultsmentioning

confidence: 99%

Sağlık çalışanlarında kanserden korunma ve erken tarama yöntemleri ile ilgili bilgi düzeylerinin değerlendirilmesi

Saginc

Taşköylü

2023

Pam Tıp Derg

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Amaç: Kanserden korunma ve erken tarama programlarının farkındalığını arttırmak için sağlık çalışanlarına planlı eğitiminin etkisini araştırmaktır. Gereç ve Yöntem: Kanser erken tanı eğitimimizde kanserden korunma ve erken tarama programlarının bilinirliği üzerine 60 sağlık çalışanına 15 soru ile anket uygulandı. Eğitime katılan 3 erkek, 57 kadın sağlık çalışanı çalışmaya alındı. Wilcoxon işaretli sıralar testi ve Mann-Whitney U testi kullanarak eğitimin sağlık çalışanları üzerindeki etkisi araştırıldı. Bulgular: 60 hemşire ve sağlık çalışanına uygulanan 15 soruluk anket yanıtlandığında Wilcoxon işaretli sıralar testi ön test doğru yanıt median 12 iken son test median doğru yanıt median 13 istatistiksel olarak anlamlı bulundu (p=0,00). Kadınlarda ön testte median doğru 12, erkeklerde ön testte median 8' dir (p=0,02). Erkekler ile kadınlar arasında ön testte belirgin kadınlar lehine doğru sayısı fazlaydı. Kadınlarda son testmedian yanıt 13, erkeklerde son testte median yanıt 11'dir (p=0,13). Yaş, eğitim durumu, hemşire ve diğer sağlık çalışanlarına göre anket ön test ve son testler arasında istatistiksel anlamlılık bulunmadı. Sonuç: Hastenede çalışan sağlık çalışanlarında kanser erken tanı yöntemleri, korunma yöntemleri ile ilgili bilgilendirme ile bilgi düzeylerinin istatistiksel anlamlı olarak arttığı görülmüştür. Erkek sağlık çalışanlarında kanser bilgilendirme eğitimi ile bilgi düzeylerinin daha fazla arttığı görüldü. Kolorektal kanserinde fekal immünokimyasal test (FITs), akciğer kanserinde düşük doz toraks BT (LDCT) ile tarama ve otofloresan görüntüleme bronkoskopisi (AFI), dar bant görüntüleme bronkoskopisi (NBI) gibi yeni tetkiklerin kullanılması erken evrede kanser tanısının konulmasını arttırır.

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Section: Resultsmentioning

confidence: 99%

Sağlık çalışanlarında kanserden korunma ve erken tarama yöntemleri ile ilgili bilgi düzeylerinin değerlendirilmesi

Saginc

Taşköylü

2023

Pam Tıp Derg

View full text Add to dashboard Cite

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“…Despite advances in surgery, radiotherapy, chemotherapy, molecularly targeted therapy, and immunotherapy, the average 5-year survival rate for lung cancer is only 19%. [1][2][3] Several strategies aim to detect lung lesions at an earlier stage: better public awareness of the 'alarm' symptoms of locoregional stage lung cancer (beyond the topic of this review), screening with imaging methods such as chest X-ray or chest CT, screening with biomarkers in blood, lung lavage fluid or exhaled air, and bronchoscopy in individuals at high risk to develop lung cancer. An overview of the most important developments in each of these fields is given.…”

Section: Introductionmentioning

confidence: 99%

Screening and Early Detection of Lung Cancer: A Comprehensive Systematic Review

Agustin Arifah Y,

Yudistiro

2024

JARMHS

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Background: Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer-related deaths globally, accounting for the greatest economic and public health burden of all cancers. In 2020, lung cancer accounted for approximately 2.2 million cases and nearly 1.8 million deaths worldwide. The aim: The aim of this study to show about screening and early detection of lung cancer. Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. This search approach, publications that came out between 2014 and 2024 were taken into account. Several different online reference sources, like Pubmed, SagePub, and Sciencedirect were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done. Result: Four publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was given to these articles. Conclusion: Early screening and diagnostic methods of lung cancer, x-ray screening is not recommended. LDCT has obvious advantages and is the most promising imaging method in early screening of lung cancer.

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“…To our knowledge, even if many biomarkers have been recently reported for early detection and follow-up of chest malignancies [ 31 ], data on FeNO levels and inflammatory cytokines in NSCLC are still few [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

IL-17 Promotes Nitric Oxide Production in Non-Small-Cell Lung Cancer

Nicola¹,

Ridolfi²,

Rolla³

et al. 2021

JCM

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Introduction: Lung cancer is the second most frequent malignancy worldwide, but its aetiology is still unclear. Inflammatory cytokines and Th cells, including Th17, are now emerging as being involved in NSCLC pathways, thus postulating a role of IL-17 in tumour angiogenesis by stimulating the vascular endothelial growth factor and the release of nitric oxide. Despite the fact that many biomarkers are used for chest malignancy diagnosis, data on FeNO levels and inflammatory cytokines in NSCLC are still few. Our study aimed to evaluate the relationship between pulmonary nitric oxide production and VEGF and Th17-related cytokines in the EBC of patients affected by early-stage NSCLC. Methods: FeNO measurement and lung function tests were performed in both patients affected by NCSLC and controls; EBC samples were also taken, and Th1 (IL-1, IL-6, IL-12, IFN-g, TNF-a), Th17 (IL-17, IL-23) and Th2 (IL-4, IL-5, IL-13) related cytokines were measured. Results: Th1 and Th17-related cytokines in EBC, except for IFN-gamma and TNF-alpha, were significantly higher in patients than in healthy controls, whereas no differences were seen for Th2-related cytokines. FeNO at the flow rate of 50 mL/s, JawNO and CalvNO levels were significantly higher in patients affected by NSCLC compared to controls. Significant correlations were found between FeNO 50 mL/s and IL-17, IL-1 and VEGF. JawNO levels positively correlated with IL-6, IL-17 and VEGF. No correlations were found between FeNO and Th2-related cytokines. Conclusion: This is the first report assessing a relationship between FeNO levels and Th17-related cytokines in the EBC of patients affected by early-stage NSCLC. IL-17, which could promote angiogenesis through the VEGF pathway, might be indirectly responsible for the increased lung production of NO in patients with NSCLC.

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Biomarkers in Early Diagnosis and Early Stage Lung Cancer: The Clinician’s Point of View

Abstract: Starting from the work of Ulivi and colleagues, we aim to summarize the research area of biomarkers for early diagnosis and early stage lung cancer.

Cited by 4 publications

References 71 publications

Sağlık çalışanlarında kanserden korunma ve erken tarama yöntemleri ile ilgili bilgi düzeylerinin değerlendirilmesi

Sağlık çalışanlarında kanserden korunma ve erken tarama yöntemleri ile ilgili bilgi düzeylerinin değerlendirilmesi

Screening and Early Detection of Lung Cancer: A Comprehensive Systematic Review

IL-17 Promotes Nitric Oxide Production in Non-Small-Cell Lung Cancer

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