Biomarkers for PTSD Susceptibility and Resilience, Ethical Issues

Bassil, Katherine; Rutten, Bart P. F.; Horstkötter, Dorothee

doi:10.1080/21507740.2019.1632964

Cited by 5 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although biomarkers showed promising initial results in predicting and diagnosing PTSD, further dedicated research is needed to determine the applicability of these biomarkers. Additionally, ethical considerations related to biomarkers for PTSD should be given attention: whereas prevention of avoidable harm and suffering can be considered a moral duty, the availability of such markers can also raise some concerns as to whether a test can be made obligatory and what the social and professional consequences of a susceptible or resilient status will be [ 142 ].…”

Section: Future Perspectives: Biomedical Markersmentioning

confidence: 99%

A Public Health Perspective of Post-Traumatic Stress Disorder

Jowf

Ahmed

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

Trauma exposure is one of the most important and prevalent risk factors for mental and physical ill-health. Prolonged or excessive stress exposure increases the risk of a wide variety of mental and physical symptoms, resulting in a condition known as post-traumatic stress disorder (PTSD). The diagnosis might be challenging due to the complex pathophysiology and co-existence with other mental disorders. The prime factor for PTSD development is exposure to a stressor, which variably, along with peritraumatic conditions, affects disease progression and severity. Additionally, many factors are thought to influence the response to the stressor, and hence reshape the natural history and course of the disease. With sufficient knowledge about the disease, preventive and intervenient methods can be implemented to improve the quality of life of the patients and to limit both the medical and economic burden of the disease. This literature review provides a highlight of up-to-date literature on traumatic stress, with a focus on causes or triggers of stress, factors that influence response to stress, disease burden, and the application of the social-ecological public health model of disease prevention. In addition, it addresses therapeutic aspects, ethnic differences in traumatic stress, and future perspectives, including potential biomarkers.

show abstract

Section: Future Perspectives: Biomedical Markersmentioning

confidence: 99%

A Public Health Perspective of Post-Traumatic Stress Disorder

Jowf

Ahmed

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…Conditions such as PTSD, with symptoms sometimes tied to feelings of guilt and shame over one's own wrongdoing (e.g. a soldier who unintentionally kills a combatant's civilian family), dampening the salience of such experiences could disrupt the formation of that individual's moral convictions [28]. Developing a narrative of self requires drawing on salient personal memories and deemphasizing memories considered not adequately reflective of themselves.…”

Section: Personal Identitymentioning

confidence: 99%

Recommendations for Responsible Development and Application of Neurotechnologies

et al. 2021

View full text Add to dashboard Cite

Advancements in novel neurotechnologies, such as brain computer interfaces (BCI) and neuromodulatory devices such as deep brain stimulators (DBS), will have profound implications for society and human rights. While these technologies are improving the diagnosis and treatment of mental and neurological diseases, they can also alter individual agency and estrange those using neurotechnologies from their sense of self, challenging basic notions of what it means to be human. As an international coalition of interdisciplinary scholars and practitioners, we examine these challenges and make recommendations to mitigate negative consequences that could arise from the unregulated development or application of novel neurotechnologies. We explore potential ethical challenges in four key areas: identity and agency, privacy, bias, and enhancement. To address them, we propose (1) democratic and inclusive summits to establish globally-coordinated ethical and societal guidelines for neurotechnology development and application, (2) new measures, including “Neurorights,” for data privacy, security, and consent to empower neurotechnology users’ control over their data, (3) new methods of identifying and preventing bias, and (4) the adoption of public guidelines for safe and equitable distribution of neurotechnological devices.

show abstract

“…Посттравматическое стрессовое расстройство (ПТСР) традиционно рассматривается как классическое «психологическое расстройство» [16][17][18], однако при этом оно характеризуется патофизиологическими сдвигами в иммунной системе, вызывая серьезные аутоиммунные [16][17][18][19], сердечно-сосудистые [20,21] и эндокринные нарушения [22]. Актуальность поиска специфических биомаркеров ПТСР [23][24][25] также связана с тем, что его диагностика в основном опирается на самооценку пациентов [26]. Однозначных данных относительно характерного для лиц с ПТСР уровня кортизола нет, зато существуют доказательства изменения его уровня в ответ на стресс.…”

Section: биомаркеры птсрunclassified

Potential Biomarkers of Posttraumatic Stress Disorder

2021

View full text Add to dashboard Cite

Background: although the search for biomarkers of mental disorders that is aimed at improving diagnosis, individualizing therapy based on knowledge of pathophysiological processes and preventing the development of mental illness is actively underway for endogenous mental disorders, the study of biological markers in non-endogenous mental disorders and posttraumatic stress disorder (PTSD) in particular has received much less attention. Aim: to analyze current state of research dedicated to genetic and biochemical biomarkers that can be used to identify high risk groups and clarify the diagnosis of PTSD. Material and method: keywords “biomarkers”, “post-traumatic stress disorder”, “pathogenesis” have been used to fi nd in PubMed articles published in 2010–2020. Conclusion: research methods for elucidating the mechanisms of PTSD are actively developing, however, the identifi cation of specifi c biomarkers (biochemical, molecular, genetic, epigenetic, neuroimaging, psychophysiological) is a complicated task. This complexity is associated with numerous pathogenic mechanisms of PTSD and frequent comorbidity with mental disorders (depression, anxiety) and somatic diseases, as well as lack of specifi city of detected biomarkers.

show abstract

Biomarkers for PTSD Susceptibility and Resilience, Ethical Issues

Cited by 5 publications

References 7 publications

A Public Health Perspective of Post-Traumatic Stress Disorder

A Public Health Perspective of Post-Traumatic Stress Disorder

Recommendations for Responsible Development and Application of Neurotechnologies

Potential Biomarkers of Posttraumatic Stress Disorder

Contact Info

Product

Resources

About