Biomarkers for post thrombotic syndrome: A case-control study

Bouman, A.C.; Cheung, Y. Whitney; Spronk, Henri M. H.; Schalkwijk, Casper G.; Cate, Hugo Ten; Wolde, Marije ten; Cate‐Hoek, Arina J. ten

doi:10.1016/j.thromres.2014.06.010

Cited by 30 publications

(23 citation statements)

References 33 publications

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“…In our cohort, circulating levels of hs-CRP were similar in the two groups of patients. This finding, which is in line with recent studies [19], may indicate a lack of sustained inflammatory response in patients with PTS. If this was the case, the role of systemic inflammation in the amplification of venous damage could be of low relevance.…”

Section: Discussionsupporting

confidence: 92%

Visceral obesity, but not metabolic syndrome, is associated with the presence of post-thrombotic syndrome

Rattazzi

Callegari

Sponchiado

et al. 2015

Thrombosis Research

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Section: Discussionsupporting

confidence: 92%

Visceral obesity, but not metabolic syndrome, is associated with the presence of post-thrombotic syndrome

Rattazzi

Callegari

Sponchiado

et al. 2015

Thrombosis Research

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“…eNOS inhibition resulted in a decrease in plasma nitrite concentration, and eNOS knockout mice had lower plasma nitrite compared to wild-type mice (Kleinbongard et al, 2003). Soluble thrombomodulin was measured as a marker of endothelial damage in which its elevated levels were associated with endothelial dysfunction and thrombosis (Ishii et al, 1991;Bouman et al, 2014;Sharma et al, 2014). ADMA is an endogenous eNOS inhibitors and its high levels are associated with vascular disorders (Böger et al, 1998;Tripepi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Endothelial dysfunction in subjects with chronic cadmium exposure

et al. 2015

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-Vascular endothelium is a target of cadmium (Cd) toxicity. Cd exposure has been reported to be associated with vascular disorders. In this study, we aimed to investigate the effects of Cd exposure on markers of endothelial function in human subjects chronically exposed to Cd. Based on blood Cd levels, seventy-five women were categorized into non-exposed, Cd-exposed and severely Cd-exposed groups. Nitrite, L-arginine, asymmetric dimethylarginine (ADMA), and soluble thrombomodulin levels in blood were measured. Nitrite levels were lower in Cd-exposed subjects than non-exposed subjects. Plasma L-arginine decreased while ADMA, an endogenous endothelial nitric oxide synthase (eNOS) inhibitor, increased in Cd-exposed subjects. Soluble thrombomodulin also increased in Cd-exposed subjects. In Cd-exposed subjects, plasma malondialdehyde and protein carbonyl groups increased while the erythrocytic glutathione decreased. Multiple linear regression analysis revealed a negative association between urinary Cd and nitrite levels in erythrocytes. Our research suggests that subjects with chronic Cd exposure have endothelial dysfunction.

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“…These data suggest the involvement of IL-6 in the induction and progression of VTE and its complications. There are, however, some studies that report no association between IL-6, either its blood level or genetic variants, and VTE [32][33][34].…”

Section: Risk Factors For Venous Thromboembolismmentioning

confidence: 99%