Biomarkers for Point-of-Care Diagnosis of Sepsis

Teggert, Andrew; Datta, Harish K.; Ali, Zulfiqur

doi:10.3390/mi11030286

Cited by 62 publications

(71 citation statements)

References 130 publications

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“…Careful evaluation of diabetic foot syndrome is essential due to the proinflammatory nature of diabetes. The investigation of any inflammatory syndrome is performed by using many markers (or combinations of them), but none has been completely validated for an accurate diagnosis of infections, including sepsis [29]. The most commonly used biomarkers of inflammation were CRP and leucocytes, while, for sepsis screening, besides these two, serum procalcitonin and presepsin are useful.…”

Section: Discussionmentioning

confidence: 99%

Clinical, Pathological and Microbiological Evaluation of Diabetic Foot Syndrome

et al. 2020

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Background and objectives: Diabetic foot ulcer (DFU) is one of the serious complications of diabetes, being related to frequent and long-term hospitalisation, reduced quality of life of the patient, amputations, a high rate of morbidity and mortality. The bacterial aetiology is complex, sometimes involving more than one pathogen, playing a major role in the infection prognosis and development of microbial resistance. This study evaluated the current state of the aetiology, clinical and pathological characteristics of DFU in a single diabetes centre in order to provide some specific measures to prevent it. Materials and Methods: This retrospective study was conducted on patients with diabetes mellitus (252 individuals diagnosed with DFU) between January 2018–December 2019. All participants were assessed based on their clinical characteristics, including complications of diabetes and pathological and microbiological evaluations. Results: The present research revealed that diabetic foot ulcer prevalence was higher in males than in females and higher in type 2 diabetic patients than in type 1 diabetic patients. The patients with diabetic foot ulcer were older, had a higher body mass index (BMI), longer diabetic duration and had more diabetic complications, such as retinopathy, diabetic polyneuropathy and diabetic kidney disease, than patients without diabetic foot ulceration. Conclusions: Taking into account all factors involved, including the aetiology and the antibiotic susceptibility pattern of these isolates, planning the suitable treatment options of patients is possible.

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Section: Discussionmentioning

confidence: 99%

Clinical, Pathological and Microbiological Evaluation of Diabetic Foot Syndrome

et al. 2020

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“…Biomarkers provide quantitative and reproducible information in an easy manner. The emergence of point of care devices could increase the interest on biomarkers for the early detection of a complicated infection by making feasible their quantification outside of the hospital, in the community 27 …”

Section: Discussionmentioning

confidence: 99%

MR‐ proADM to detect specific types of organ failure in infection

Andrés

Andaluz‐Ojeda

Cicuéndez

et al. 2020

Eur J Clin Investigation

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Background: Following the SEPSIS-3 consensus, detection of organ failure as assessed by the SOFA (Sequential Organ Failure Assessment) score, is mandatory to detect sepsis. Calculating SOFA outside of the Intensive Care Unit (ICU) is challenging. The alternative in this scenario, the quick SOFA, is very specific but less sensible. Biomarkers could help to detect the presence of organ failure secondary to infection either in ICU and non-ICU settings. Materials and methods: We evaluated the ability of four biomarkers (C-Reactive protein (CRP), lactate, mid-regional proadrenomedullin (MR-proADM) and procalcitonin (PCT)) to detect each kind of organ failure considered in the SOFA in 213 patients with infection, sepsis or septic shock, by using multivariate regression analysis and calculation of the area under the receiver operating curve (AUROC). Results: In the multivariate analysis, MR-proADM was an independent predictor of five different failures (respiratory, coagulation, cardiovascular, neurological and renal). In turn, lactate predicted three (coagulation, cardiovascular and neurological) and PCT two (cardiovascular and renal). CRP did not predict any of the individual components of SOFA. The highest AUROCs were those of MR-proADM and PCT to detect cardiovascular (AUROC, CI95%): MR-proADM (0.82 [0.76-0.88]), PCT

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“…There are a very large number of biomarkers that have been studied for sepsis and we have previously reviewed these. 23 We have focussed here on CRP, PCT and IL-6 as amongst the most widely studied biomarkers for the diagnosis of sepsis. PCT and CRP are produced in response to infection and/or inflammation and are the most widely used clinical biomarkers, apart from lactate, for the diagnosis and management of patients with sepsis.…”

Section: Sepsis Poc Diagnostic With Cea Detectionmentioning

confidence: 99%