MR‐ proADM to detect specific types of organ failure in infection

Andrés, Cristina; Andaluz‐Ojeda, David; Cicuéndez, Ramón; Nogales, Leonor; Martín, Silvia; Martín-Fernández, Marta; Almansa, Raquel; Calvo, Dolores; Esteban-Velasco, Maria Carmen; Vaquero‐Roncero, Luis Mario; Ríos-Llorente, Alberto; Sánchez-Barrado, Elisa; Muñoz‐Bellvís, Luís; Aldecoa, César; Bermejo-Martín, Jesús F.

doi:10.1111/eci.13246

Cited by 19 publications

(15 citation statements)

References 32 publications

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“…In fact, levels of MR-proADM can potentially reflect the severity of organ dysfunction, even in the first stages of the disease, in the progression of systemic inflammatory response, in the movement from sepsis to septic shock, and in the mortality risk of septic patients [ 11 , 12 ]. A prospective observational study conducted with 213 septic patients showed that MR-proADM was able to predict system dysfunction (respiratory, coagulation, renal, neurological, and cardiovascular) and was well-correlated with Sequential Organ Failure Assessment (SOFA) score components [ 13 ]. The same results were obtained by Onal et al [ 11 ], who concluded that MR-proADM could be a good alternative to SOFA score.…”

Section: Role Of Mr-proadm In Icu and In Edmentioning

confidence: 99%

Proadrenomedullin in Sepsis and Septic Shock: A Role in the Emergency Department

et al. 2021

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Sepsis and septic shock represent a leading cause of mortality in the Emergency Department (ED) and in the Intensive Care Unit (ICU). For these life-threating conditions, different diagnostic and prognostic biomarkers have been studied. Proadrenomedullin (MR-proADM) is a biomarker that can predict organ damage and the risk of imminent death in patients with septic shock, as shown by a large amount of data in the literature. The aim of our narrative review is to evaluate the role of MR-proADM in the context of Emergency Medicine and to summarize the current knowledge of MR-proADM as a serum indicator that is useful in the Emergency Department (ED) to determine an early diagnosis and to predict the long-term mortality of patients with sepsis and septic shock. We performed an electronic literature review to investigate the role of MR-proADM in sepsis and septic shock in the context of ED. We searched papers on PubMed®, Cochrane®, UptoDate®, and Web of Science® that had been published in the last 10 years. Data extracted from this literature review are not conclusive, but they show that MR-proADM may be helpful as a prognostic biomarker to stratify the mortality risk in cases of sepsis and septic shock with different degrees of organ damage, guiding emergency physicians in the diagnosis and the succeeding therapeutic workup. Sepsis and septic shock are conditions of high complexity and have a high risk of mortality. In the ED, early diagnosis is crucial in order to provide an early treatment and to improve patient survival. Diagnosis and prognosis are often the result of a combination of several tests. In our opinion, testing for MR-proADM directly in the ED could contribute to improving the prognostic assessment of patients, facilitating the subsequent clinical management and intensive treatment by the emergency physicians, but more studies are needed to confirm these results.

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Section: Role Of Mr-proadm In Icu and In Edmentioning

confidence: 99%

Proadrenomedullin in Sepsis and Septic Shock: A Role in the Emergency Department

et al. 2021

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“…Finally, Bermejo et al analyzed the ability of MR-ProADM and other markers to detect the different possible organ failures in patients with infection. In his research, the AUC-ROC of MR-ProADM for the diagnosis of organ failure was 0.79 (0.72–0.86), considered a very good predictive capacity, above that obtained with other biomarkers studied in the same work such as PCT: 0.62 (0.54–0.70), lactate: 0.69 (0.61–0.78), or CRP: 0.54 (0.45–0.63) [ 66 ]. Biomarkers could add valuable information to clinical judgment to detect the presence of organ failure early on during infection.…”

Section: The Best Biomarkers In Intensive and Perioperative Carementioning

confidence: 86%

Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence

Hernández

Rueda

2023

JPM

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A biomarker is a molecule that can be measured in a biological sample in an objective, systematic, and precise way, whose levels indicate whether a process is normal or pathological. Knowing the most important biomarkers and their characteristics is the key to precision medicine in intensive and perioperative care. Biomarkers can be used to diagnose, in assessment of disease severity, to stratify risk, to predict and guide clinical decisions, and to guide treatments and response to them. In this review, we will analyze what characteristics a biomarker should have and how to ensure its usefulness, and we will review the biomarkers that in our opinion can make their knowledge more useful to the reader in their clinical practice, with a future perspective. These biomarkers, in our opinion, are lactate, C-Reactive Protein, Troponins T and I, Brain Natriuretic Peptides, Procalcitonin, MR-ProAdrenomedullin and BioAdrenomedullin, Neutrophil/lymphocyte ratio and lymphopenia, Proenkephalin, NefroCheck, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin 6, Urokinase-type soluble plasminogen activator receptor (suPAR), Presepsin, Pancreatic Stone Protein (PSP), and Dipeptidyl peptidase 3 (DPP3). Finally, we propose an approach to the perioperative evaluation of high-risk patients and critically ill patients in the Intensive Care Unit (ICU) based on biomarkers.

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“…It has biological properties, including vasodilating, inotropic, diuretic, natriuretic, and bronchodilating. In one study, mid-regional pro adrenomedullin (MR-proADM) was an independent predictor of five different organ failures (respiratory, coagulation, cardiovascular, neurological, and renal), compared to lactate which predicted three (coagulation, cardiovascular and neurological), PCT two (cardiovascular and renal) and CRP (none) [50]. MR-proADM most accurately identified patients with a high likelihood of further disease progression compared to other biomarkers and clinical scores [51].…”

Section: Hormones and Peptide Precursorsmentioning

confidence: 99%

Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

et al. 2022

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A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to answer the question, "Do biomarkers in patients with sepsis or septic shock predict mortality, multiple organ dysfunction syndrome (MODS), or organ dysfunction?" We also discuss the role of pro- and anti-inflammatory biomarkers and biomarkers associated with intestinal permeability, endothelial injury, organ dysfunction, blood–brain barrier (BBB) breakdown, brain injury, and short and long-term mortality. For sepsis, a range of biomarkers is identified, including fluid phase pattern recognition molecules (PRMs), complement system, cytokines, chemokines, damage-associated molecular patterns (DAMPs), non-coding RNAs, miRNAs, cell membrane receptors, cell proteins, metabolites, and soluble receptors. We also provide an overview of immune response biomarkers that can help identify or differentiate between systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and sepsis-associated encephalopathy. However, significant work is needed to identify the optimal combinations of biomarkers that can augment diagnosis, treatment, and good patient outcomes.

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MR‐ proADM to detect specific types of organ failure in infection

Cited by 19 publications

References 32 publications

Proadrenomedullin in Sepsis and Septic Shock: A Role in the Emergency Department

Proadrenomedullin in Sepsis and Septic Shock: A Role in the Emergency Department

Biomarkers as Prognostic Predictors and Therapeutic Guide in Critically Ill Patients: Clinical Evidence

Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

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