Biomarker potential of lncRNA GNAS-AS1 in osteosarcoma prognosis and effect on cellular function

Mi, Zhanhu; Dong, Yanyun; Wang, Zhibiao; Ye, Peng

doi:10.1186/s13018-021-02611-2

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…CRNDE could promote the malignant progression of glioma by attenuating the miR-384/PIWIL4/STAT3 axis (27). GNAS-AS1 has been reported to be related to the malignant progression of osteosarcoma, breast cancer, nasopharyngeal carcinoma, and non-small cell lung cancer (28)(29)(30)(31), however, its function in glioma remains unclear. In this study, we determined that GNAS-AS1 overexpression may contribute to poor prognosis in glioma patients.…”

Section: Discussionmentioning

confidence: 99%

Necroptosis-related lncRNAs: establishment of a gene module and distinction between the cold and hot tumors in glioma

Cao

Shan

et al. 2023

Front. Oncol.

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BackgroundGliomas are the most common primary tumors of the central nervous system and portend a poor prognosis. The efficacy of emerging and promising immunotherapies varies significantly among individuals. Distinction and transformation of cold and hot tumors may improve the antitumor efficacy of immunotherapy.Methods and ResultsIn this study, we constructed a necroptosis-related lncRNA module based on public databases. The association of this module with survival was assessed using the Cox regression, Kaplan-Meier survival analysis, and nomogram, external validation was also conducted in another public database. Furthermore, we performed gene set enrichment analysis (GSEA), immune checkpoint and tumor microenvironment analysis, and in vitro qRT-PCR validation. Finally, we clustered all samples into 2 clusters based on the expression of model lncRNAs and identified cluster 1 as cold tumors with fewer infiltrating T cells.ConclusionsIdentifying cold and hot tumors by necroptosis-related lncRNAs can help available immunotherapeutic strategies to achieve efficacy in the precise treatment of individuals. Prior treatment failure can be overcome by targeting necroptosis-related lncRNAs.

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Section: Discussionmentioning

confidence: 99%

Necroptosis-related lncRNAs: establishment of a gene module and distinction between the cold and hot tumors in glioma

Cao

Shan

et al. 2023

Front. Oncol.

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“…Although there are no studies on the relationship between GNAS-AS1 and Wnt/β -catenin signaling Pathway, we have reason to believe that GNAS-AS1 can affect the process and development of IDD by regulating Wnt/β -catenin Signaling Pathway. GNAS-AS1 has also been reported as a prognostic indicator of osteosarcoma (Mi et al, 2021). MIR100HG promotes the development of triple-negative breast cancer (TNBC) by regulating the P27 gene and sponging mir-5590-3p.…”

Section: Discussionmentioning

confidence: 99%

Key LncRNAs Associated With Oxidative Stress Were Identified by GEO Database Data and Whole Blood Analysis of Intervertebral Disc Degeneration Patients

Jiang

Guo

et al. 2022

Front. Genet.

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Background: Intervertebral disc degeneration (IDD) is a major cause of low back pain, but the onset and progression of IDD are unknown. Long non-coding RNA (lncRNA) has been validated to play a critical role in IDD, while an increasing number of studies have linked oxidative stress (OS) to the initiation and progression of IDD. We aim to investigate key lncRNAs in IDD through a comprehensive network of competing endogenous RNA (ceRNA) and to identify possible underlying mechanisms.Methods: We downloaded IDD-related gene expression data from the Gene Expression Omnibus (GEO) database and obtained differentially expressed-lncRNAs (DE-lncRNA), -microRNAs (DE-miRNA), and -messenger RNAs (DE-mRNA) by bioinformatics analysis. The OS-related lncRNA-miRNA-mRNA ceRNA interaction axis was constructed and key lncRNAs were identified based on ceRNA theory. We performed gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses on mRNAs regulated by lncRNAs in the ceRNA network. Single sample gene set enrichment analysis (ssGSEA) was used to reveal the immune landscape. Expression of key lncRNAs in IDD was assessed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).Results: In this study, 111 DE-mRNAs, 20 DE-lncRNAs, and 502 DE-miRNAs were identified between IDD patients and controls, and 16 OS-related DE-lncRNAs were also identified. The resulting lncRNA-miRNA-mRNA network consisted of eight OS-related DE-lncRNA nodes, 24 DE-miRNA nodes, 70 DE-mRNA nodes, and 183 edges. Functional enrichment analysis suggested that the ceRNA network may be involved in regulating biological processes related to cytokine secretion, lipid, and angiogenesis. We also identified four key lncRNAs, namely lncRNA GNAS-AS1, lncRNA MIR100HG, lncRNA LINC01359, and lncRNA LUCAT1, which were also found to be significantly associated with immune cells.Conclusion: These results provide novel insights into the potential applications of OS-related lncRNAs in patients with IDD.

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“…It was found that the expression of lncRNA GNAS antisense (lncRNA GNAS-AS1) could significantly increase in OS cells and tissues, which were positively correlated with Enneking stage and distant metastasis. Its high expression often predicted the short overall survival time ( Mi et al, 2021 ). Through regulating miR-490-3p, lncRNA GNAS-AS1 could play a major role in cell proliferation, migration and invasion, which could be an independent prognostic predictor of OS, providing a new therapeutic strategy for OS ( Mi et al, 2021 ).…”

Section: Diagnostic Biomarkersmentioning

confidence: 99%

“…Its high expression often predicted the short overall survival time ( Mi et al, 2021 ). Through regulating miR-490-3p, lncRNA GNAS-AS1 could play a major role in cell proliferation, migration and invasion, which could be an independent prognostic predictor of OS, providing a new therapeutic strategy for OS ( Mi et al, 2021 ). The expression of circRNA-mitochondrial tRNA translation optimization 1 (circ_MTO1) in OS is low, its expression level is significantly correlated with Enneking staging, and its high expression in the tumor meant that the Enneking staging was lower in OS patients who had better neoadjuvant chemotherapy response and longer disease-free survival (DFS) ( Shi et al, 2021 ).…”

Section: Diagnostic Biomarkersmentioning

confidence: 99%

Non-coding RNAs as potential biomarkers in osteosarcoma

et al. 2022

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Osteosarcoma (OS) is a primary solid malignant tumor that occurs most frequently in the metaphysis of long bones. More likely to happen to children and adolescents. OS has high mortality and disability rate. However, the etiology and pathogenesis of OS have not been fully understood till now. Due to the lack of effective biomarkers, OS cannot be precisely detected in the early stage. With the application of next-generation and high-throughput sequencing, more and more abnormally expressed non-coding RNAs(ncRNAs) have been identified in OS. Growing evidences have suggested the ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), have played an important role in the tumorigenesis and progression of OS. Thus, they can be served as novel biomarkers for diagnosis, treatment and prognosis. This review summarized the application of ncRNA as biomarkers in OS in detail, and discussed the limitation and future improvement of the potential biomarkers.

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Biomarker potential of lncRNA GNAS-AS1 in osteosarcoma prognosis and effect on cellular function

Cited by 7 publications

References 32 publications

Necroptosis-related lncRNAs: establishment of a gene module and distinction between the cold and hot tumors in glioma

Necroptosis-related lncRNAs: establishment of a gene module and distinction between the cold and hot tumors in glioma

Key LncRNAs Associated With Oxidative Stress Were Identified by GEO Database Data and Whole Blood Analysis of Intervertebral Disc Degeneration Patients

Non-coding RNAs as potential biomarkers in osteosarcoma

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