Non-coding RNAs as potential biomarkers in osteosarcoma

Fan, Lijuan; Zhong, Zhenhao; Lin, Yubo; Li, Jitian

doi:10.3389/fgene.2022.1028477

Cited by 5 publications

(1 citation statement)

References 116 publications

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“…Biomarkers have become a new prospect due to their advantages of being simple to collect samples, minimum injury to the body, high sensitivity, and specificity ( 72 ). OS cannot be effectively identified at an early stage without efficient biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research

Chen,

He,

Liu

et al. 2024

Front. Oncol.

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BackgroundOsteosarcoma (OS) is the most common bone malignant tumor in children and adolescents. Recent research indicates that non-coding RNAs (ncRNAs) have been associated with OS occurrence and development, with significant progress made in this field. However, there is no intelligent structure prediction and literature visualization analysis in this research field. From the perspective of intelligent knowledge structure construction and bibliometrics, this study will comprehensively review the role of countries, institutions, journals, authors, literature citation relationships and subject keywords in the field of ncRNAs in OS. Based on this analysis, we will systematically analyze the characteristics of the knowledge structure of ncRNAs in OS disease research and identify the current research hotspots and trends.MethodsThe Web of Science Core Collection (WoSCC) database was searched for articles on ncRNAs in OS between 2001 and 2023. This bibliometric analysis was performed using VOSviewers, CiteSpace, and Pajek.ResultsThis study involved 15,631 authors from 2,631 institutions across 57 countries/regions, with a total of 3,642 papers published in 553 academic journals. China has the highest number of published papers in this research field. The main research institutions include Nanjing Medical University (n = 129, 3.54%), Shanghai Jiao Tong University (n = 128, 3.51%), Zhengzhou University (n = 110, 3.02%), and China Medical University (n = 109, 2.99%). Oncology Letters (n =139, 3.82%), European Review for Medical Pharmacological Sciences (120, 3.31%), and Molecular Medicine Reports (n = 95, 2.61%) are the most popular journals in this field, with Oncotarget being the most co-cited journal (Co-Citation = 4,268). Wei Wang, Wei Liu, and Zhenfeng Duan published the most papers, with Wang Y being the most co-cited author. “miRNA”, “lncRNA” and “circRNA” are the main focuses of ncRNAs in OS studies. Key themes include “migration and invasion”, “apoptosis and proliferation”, “prognosis”, “biomarkers” and “chemoresistance”. Since 2020, hotspots and trends in ncRNA research in OS include “tumor microenvironment”, “immune” and “exosome”.ConclusionThis study represents the first comprehensive bibliometric analysis of the knowledge structure and development of ncRNAs in OS. These findings highlight current research hotspots and frontier directions, offering valuable insights for future studies on the role of ncRNAs in OS

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Section: Discussionmentioning

confidence: 99%

Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research

Chen,

He,

Liu

et al. 2024

Front. Oncol.

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METTL3-mediated m6A modification of circRNF220 modulates miR-330-5p/survivin axis to promote osteosarcoma progression

Liu,

Li,

Jin

et al. 2023

J Cancer Res Clin Oncol

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Background Circular RNAs (circRNAs) play a crucial role in regulating various physiological processes. However, the precise regulatory mechanisms of circRNF220s in osteosarcoma (OS) are not well understood. Methods The abundances of circRNF220, miR-330-5p, and survivin were determined using qRT-PCR. To assess the m6A accumulation in circRNF220, a methylated RNA immunoprecipitation (Me-RIP) assay was conducted. Cellular multiplication, motility, and invasion were examined using the cell Counting Kit-8 (CCK-8), EdU, colony formation, Transwell, and wound-healing assays. The binding relationships were measured through RNA immunoprecipitation (RIP) and luciferase reporter assays. In vivo functionality was assessed using xenograft models. Results CircRNF220 was identified as being overexpressed in both OS cells and tissues. In vitro experiments demonstrated that silencing circRNF220 impeded the proliferation, invasion, and motility of OS cells. Similarly, in vivo studies confirmed that downregulating circRNF220 inhibited the growth of OS. Further mechanistic investigations unveiled that METTL3-modulated circRNF220 regulated the progression of OS by upregulating survivin expression through acting as a sponge for miR-330-5p. Conclusion The modulation of METTL3-regulated circRNF220 has been found to promote the progression of OS by modulating the miR-330-5p/survivin axis. This novel finding suggests a potentially unique approach to managing OS.

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miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling

et al. 2023

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Non-coding RNAs as potential biomarkers in osteosarcoma

Cited by 5 publications

References 116 publications

Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research

Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research

METTL3-mediated m6A modification of circRNF220 modulates miR-330-5p/survivin axis to promote osteosarcoma progression

miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling

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