BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries

Zeller, Tanja; Hughes, Maria; Tuovinen, Tarja; Schillert, Arne; Conrads-Frank, Annette; Ruijter, Hester M. den; Schnabel, Renate B.; Kee, Frank; Salomaa, Veikko; Siebert, Uwe; Thorand, Barbara; Ziegler, Andreas; Breek, Heico; Pasterkamp, Gérard; Kuulasmaa, Kari; Köenig, Wolfgang; Blankenberg, Stefan

doi:10.1007/s10654-014-9952-x

Cited by 89 publications

(74 citation statements)

References 35 publications

(45 reference statements)

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“…The present study is a substudy of the BiomarCaRE consortium 13. Current analyses include BiomarCaRE cohorts with available information on AF status at baseline and follow-up (DanMONICA, FINRISK, Moli-sani and Northern Sweden), totaling N=79,793 individuals.…”

Section: Methodsmentioning

confidence: 99%

“…Our study comprises a subset of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, which provides information on the epidemiology of AF and its risk factors in European community cohorts 13. Our objective was to systematically examine sex differences in AF incidence, and in the association of AF with mortality, classical cardiovascular risk factors and biomarkers in Europe.…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts

et al. 2017

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BACKGROUND:Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS:In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Molisani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS:Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12-1.23 in women versus 1.31; 95% CI 1.25-1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81-0.90 versus 0.92; 95% CI, 0.88-0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS:Lifetime risk of AF was high, and AF was strongly associated with increased mortality both in women and men. Body mass index explained the largest proportion of AF risk. Observed sex differences in the association of body mass index and total cholesterol with AF need to be evaluated for underlying pathophysiology and relevance to sexspecific prevention strategies. ORIGINAL RESEARCH ARTICLE A trial fibrillation (AF) is a common cardiac disease that increases the risk of morbidity and mortality in aging women and men. Sex Differences and Similarities in Atrial1-3 Considerable sex differences in prevalence, incidence, and mortality have been reported.2,4 AF prevalence in middle-aged and older community cohorts is almost twice as high in men as in women. [5][6][7] The increasing prevalence of AF and subsequent public health and economic burden require research efforts to understand sex differences in disease distribution and risk factor associations. 5 The onset of AF diminishes the survival advantage in women. 8 Risk of adverse outcomes in AF also appears to differ by sex, eg, st...

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts

et al. 2017

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“…We applied a targeted quantitative metabolomic approach to analyze the rat plasma samples using the Biocrates Absolute IDQ ® p180 kit (Biocrates Life Sciences AG, Innsbruck, Austria). This kit covers endogenous metabolites playing pleiotropic roles in bioenergetics metabolism, cell signaling, and cell structures and previously involved in numerous diseases including cardiovascular ones …”

Section: Methodsmentioning

confidence: 99%

Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

Barca

Bakhta

Kalakech

et al. 2016

JAHA

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BackgroundRemote ischemic preconditioning (RIPC) is an attractive therapeutic procedure for protecting the heart against ischemia/reperfusion injury. Despite evidence of humoral mediators transported through the circulation playing a critical role, their actual identities so far remain unknown. We sought to identify plasmatic RIPC‐induced metabolites that may play a role.Methods and ResultsRat plasma samples from RIPC and control groups were analyzed using a targeted metabolomic approach aimed at measuring 188 metabolites. Principal component analysis and orthogonal partial least‐squares discriminant analysis were used to identify the metabolites that discriminated between groups. Plasma samples from 50 patients subjected to RIPC were secondarily explored to confirm the results obtained in rats. Finally, a combination of the metabolites that were significantly increased in both rat and human plasma was injected prior to myocardial ischemia/reperfusion in rats. In the rat samples, 124 molecules were accurately quantified. Six metabolites (ornithine, glycine, kynurenine, spermine, carnosine, and serotonin) were the most significant variables for marked differentiation between the RIPC and control groups. In human plasma, analysis confirmed ornithine decrease and kynurenine and glycine increase following RIPC. Injection of the glycine and kynurenine alone or in combination replicated the protective effects of RIPC seen in rats.ConclusionsWe have hereby reported significant variations in a cocktail of amino acids and biogenic amines after remote ischemic preconditioning in both rat and human plasma.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01390129.

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“…Several recent studies have demonstrated the association between the risk of major cardiovascular events and detectable, presumably still normal, cTn values measured with highly sensitive cTnI and cTnT assays [110][111][112][113]147]. These studies give rise to the question of whether there is a myocardial injury threshold beyond which individual risk increases thus being of potential clinical utility in cardiovascular risk prediction.…”

Section: Clinical Relevance Of Gender-specific Decision Values For Ctmentioning

confidence: 99%

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

Clerico

Zaninotto

Ripoli

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit (99th URL) should be considered clinically relevant, this cut-off being measured with an imprecision ≤10 CV%. In theory 99th URL values strongly depend not only on demographic and physiological variables (i.e. criteria for considering the reference population "healthy"), but also on the analytical performance of cTn methods and mathematical algorithms used for the calculation. The aim of the present article was therefore to review the methodological and pathophysiological factors affecting the evaluation and calculation of the 99th URL for cTn assay. The critical analysis made showed that no uniform procedure is followed, and nor have experts or regulatory bodies provided uniform guidelines for researchers or cTn assays manufacturers as an aid in "their quest to define normality". In particular, little attention has been paid to the way in which a healthy reference population is to be selected, or the criteria for calculating the 99th URL value for cTn assays, thus highlighting the need for international recommendations not only for demographic and physiological variables criteria for defining a healthy reference population, but also for calculating mathematical algorithms for establishing/ calculating clinical decision values. An expert consensus group, comprising laboratory and clinical scientists, biomedical statisticians, industrial and regulatory representatives, should be responsible for drawing up these guidelines.

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BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries

Cited by 89 publications

References 35 publications

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts

Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications

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