Biom-07. Quantitative MGMT Promoter Methylation Index Indicates a Non-Linear Prognostic Effect in Glioblastoma, Suggesting That Use of Optimal Cutoff Points May Be Clinically Disadvantageous
Abstract:BACKGROUND
Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emerged as a clinically relevant prognostic marker in glioblastoma (GBM). Methylation of the MGMT promoter has been shown to increase chemotherapy efficacy. While traditionally reported as a binary marker, recent methodological advancements have led to quantitative approaches that measure methylation, providing clearer insights into methylation’s functional relationship with survival.
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