Biology of Trypanosoma cruzi: An update

Martins, André Vianna; Gomes, Andréia Patrícia; Mendonça, Eduardo Gomes de; Fietto, Juliana Lopes Rangel; Santana, Luiz Alberto; Oliveira, Maria Goreti de Almeida; Geller, Mauro; Santos, Ramon de Freitas; Vitorino, Rodrigo Roger; Siqueira-Batista, Rodrigo

doi:10.1016/s0123-9392(12)70057-7

Cited by 13 publications

(7 citation statements)

References 87 publications

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“…The size and shape of the reservosomes, glycosomes, and acidocalcisomes also differs between the two sizes of epimastigotes observed in Trypanosoma sp. AAT that is both cell cycle and nutrient dependent in other trypanosomes, especially T. brucei , which has been extensively studied [18, 19, 56, 68]. Put simply, due to the similarity in nutrient availability for the two epimastigotes observed in this study, differences in organelle structure is most likely cell-cycle dependent.…”

Section: Discussionmentioning

confidence: 76%

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A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia

et al. 2017

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BackgroundMolecular and structural information on avian Trypanosoma spp. throughout Australia is limited despite their intrinsic value in understanding trypanosomatid evolution, diversity, and structural biology. In Western Australia tissue samples (n = 429) extracted from 93 birds in 25 bird species were screened using generic PCR primers to investigate the diversity of Trypanosoma spp. To investigate avian trypanosome structural biology the first 3-dimensional ultrastructural models of a Trypanosoma spp. (Trypanosoma sp. AAT) isolated from a bird (currawong, Strepera spp.) were generated using focussed ion beam milling combined with scanning electron microscopy (FIB-SEM).ResultsHere, we confirm four intercontinental species of avian trypanosomes in native Australian birds, and identify a new avian Trypanosoma. Trypanosome infection was identified in 18 birds from 13 different bird species (19%). A single new genotype was isolated and found to be closely related to T. culicavium (Trypanosoma sp. CC2016 B002). Other Trypanosoma spp. identified include T. avium, T. culicavium, T. thomasbancrofti, Trypanosoma sp. TL.AQ.22, Trypanosoma sp. AAT, and an uncharacterised Trypanosoma sp. (group C-III sensu Zidková et al. (Infect Genet Evol 12:102-112, 2012)), all previously identified in Australia or other continents. Serially-sectioning Trypanosoma sp. AAT epimastigotes using FIB-SEM revealed the disc-shaped kinetoplast pocket attached perpendicular to the branching mitochondrion. Additionally, the universal minicircle sequence within the kinetoplast DNA and the associated binding protein were determined in Trypanosoma sp. AAT.ConclusionsThese results indicate that bird trypanosomes are relatively conserved across continents, while being locally diverse, which supports the hypothesis that bird trypanosomes exist as fewer species than described in the literature. Evidence exists that avian Trypanosoma spp. are infecting mammals and could be transmitted by haemadipsid leeches. Trypanosoma sp. AAT is most likely a separate species currently found only in Australia and the first 3-dimentional ultrastructural analysis of an avian trypanosome provides interesting information on their morphology and organelle arrangement.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2173-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 76%

“…The kDNA is contained inside the kinetoplast pocket that is part of the single large mitochondrion [16, 17], which is unusual in both its structural and functional properties [18, 19]. The structure and size of Trypanosoma mitochondria are variable and cell cycle dependant.…”

Section: Introductionmentioning

confidence: 99%

A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia

et al. 2017

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“…particularly so in VAP isolates [ 16 ]. Time-trend data pertaining to 741 mechanically ventilated patients with suspected nosocomial pneumonia were available between 2007 and 2010 for the 3 ICUs of the Hermanos Ameijeiras Hospital, Havana, Cuba [ 35 ]. The most prevalent bacterial infections were Acinetobacter spp.…”

Section: Resultsmentioning

confidence: 99%

“…prevalence rate and a 4% and 11% increase in prevalence of Acinetobacter spp. and Klebsiella spp., respectively [ 35 ]. The distribution of infectious agents in the ICU of San Fernando, Trinidad, was different to that in ICUs of other countries in that Citrobacter spp.…”

Section: Resultsmentioning

confidence: 99%

Gram-Negative Infections in Adult Intensive Care Units of Latin America and the Caribbean

Luna

Noriega

Bavestrello

et al. 2014

Critical Care Research and Practice

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This review summarizes recent epidemiology of Gram-negative infections in selected countries from Latin American and Caribbean adult intensive care units (ICUs). A systematic search of the biomedical literature (PubMed) was performed to identify articles published over the last decade. Where appropriate, data also were collected from the reference list of published articles, health departments of specific countries, and registries. Independent cohort data from all countries (Argentina, Brazil, Chile, Colombia, Cuba, Mexico, Trinidad and Tobago, and Venezuela) signified a high rate of ICU infections (prevalence: Argentina, 24%; Brazil, 57%). Gram-negative pathogens, predominantly Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, accounted for >50% of ICU infections, which were often complicated by the presence of multidrug-resistant strains and clonal outbreaks. Empirical use of antimicrobial agents was identified as a strong risk factor for resistance development and excessive mortality. Infection control strategies utilizing hygiene measures and antimicrobial stewardship programs reduced the rate of device-associated infections. To mitigate the poor health outcomes associated with infections by multidrug-resistant Gram-negative bacteria, urgent focus must be placed on infection control strategies and local surveillance programs.

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“…The parasites are then accidentally rubbed into the bite wound or enter the host bloodstream through the mucosa. Further transmission routes include the ingestion of contaminated food, transmission by infected blood products and congenital transmission [1] , [2] . People who develop chronic Chagas disease face severe medical, social and also economic challenges as they are often vulnerable to superinfections and struggle with a limited ability to work [3] , [4] .…”

Section: Introductionmentioning

confidence: 99%

Metabolites as predictive biomarkers for Trypanosoma cruzi exposure in triatomine bugs

Eberhard

Klimpel

Guarneri³

et al. 2021

Computational and Structural Biotechnology Journal

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Biology of Trypanosoma cruzi: An update

Cited by 13 publications

References 87 publications

A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia

A comparative molecular and 3-dimensional structural investigation into cross-continental and novel avian Trypanosoma spp. in Australia

Gram-Negative Infections in Adult Intensive Care Units of Latin America and the Caribbean

Metabolites as predictive biomarkers for Trypanosoma cruzi exposure in triatomine bugs

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