Biology of the Hair Follicle

Vogt, Annika; McElwee, Kevin J.; Blume‐Peytavi, Ulrike

doi:10.1007/978-3-540-46911-7_1

Cited by 54 publications

(52 citation statements)

References 74 publications

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“…15,16 Type of AA: In the present study most common type of AA is patchy type 73%, followed by ophiasis in 7%, sisaphio in 7%, totalise in 4%, universalise in 3%, reticulate in 3%, diffuse in 3% of cases which were comparable to Thomas et al 5 study.…”

Section: Absolute Eosinophil Count and Serum Ige Levelssupporting

confidence: 89%

A Clinical and Investigatory Study of Alopecia Areata With Special Reference to Systemic Associations in 100 Patients

Guruprasad¹,

Chalam²,

Priyadarshini³

et al. 2015

jemds

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BACKGROUND: Alopecia areata is an autoimmune condition with a worldwide occurrence. It usually presents as patchy, non-scarring hair loss. There is a paucity of clinical data in Indians. OBJECTIVES: To study the clinical profile and to know the association with various systemic and dermatological disorders. METHODS: A descriptive study was conducted on 100 cases of alopecia areata after taking informed consent, over a period of 16 months from December 2012 to April 2014. A detailed history of the patient regarding associated systemic and dermatological disorders and various autoimmune disorders were documented, relevant investigations were done. RESULTS: Incidence of alopecia areata in patients attending dermatology out-patient department was 1.7%. There was slight male preponderance (51%). Most common age group involved was 20-40yrs. (47%). Alopecia areata was higher among low socioeconomic group (62%). Recurrences of AA was noted in 14% of cases. Stress acting as triggering factor in 12%. Pregnancy and postpartum accounted for 4% of cases. Atopic dermatitis was noted in 1%, seborrheic dermatitis was noted in 1%, lichen planus was noted in 2%, psoriasis noted in 1% cases. Average age of onset of alopecia areata in atopics was 7.9 years. Occiput was the most common site accounting for 39.3% of cases. Nail pitting was noted in 7% of cases. In 2 cases 20 nail dystrophy was noted. Patchy type was the most common type of alopecia seen in 73% of patients. As per IKEDAS classification -71% cases belonged to common type, 18% to atopic type, 5% to pre hypertensive, 6% to autoimmune type. Bronchial asthma was noted in 3%, Diabetes mellitus in 5%, hypothyroidism noted in 12% of cases.

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Section: Absolute Eosinophil Count and Serum Ige Levelssupporting

confidence: 89%

A Clinical and Investigatory Study of Alopecia Areata With Special Reference to Systemic Associations in 100 Patients

Guruprasad¹,

Chalam²,

Priyadarshini³

et al. 2015

jemds

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“…43 The cycling of these phases is finely coordinated by the expression of hormones, cytokines, transcription factors, and their corresponding receptors and is carefully regulated through endocrine, paracrine, and autocrine routes. The disruption of these finely tuned pathways can result in the development of hair diseases.…”

Section: Pathology Key Pointsmentioning

confidence: 99%

Alopecia areata update

Alkhalifah

Alsantali

Wang

et al. 2010

Journal of the American Academy of Dermatology

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424

223

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“…In general, lighter hair is thinner while darker hair is thicker; in Europeans, fair hair measures about 40-80 µm, compared to dark brown hair, which has an average diameter of 50-90 µm (Vogt et al, 2008). Across ethnicities, the cross-sectional shape of the hair follicle determines the shape of the hair shaft in determining its curliness-round follicles produce straight hair while flat or oblong follicles produce wavy or curly hair.…”

mentioning

confidence: 99%

Variation and Heritability in Hair Diameter and Curvature in an Australian Twin Sample

Brims²,

McNevin

et al. 2016

Twin Res Hum Genet

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Hair diameter and curvature are two characteristics of human scalp hair used in forensic contexts. While previous data show that subjective categorization of hair curvature is highly heritable, the heritability of objectively measured curvature and diameter, and variability of hair characteristics within each individual have not yet been studied. The present study measured hair diameter and curvature using an optical fiber diameter analyzer in a sample of 2,332 twins and siblings. Heritability was estimated using maximum likelihood structural equation modeling. Results show sex differences in the magnitude of genetic influence for mean diameter and curvature, with the vast majority of the variance accounted for by genetic effects in males (diameter = 86%, curvature = 53%) and females (diameter = 77%, curvature = 61%). The consistency of diameter (variance within an individual) was also highly heritable, but did not show sex limitation, with 68% of the variance accounted for by genetic factors. Moderate phenotypic correlations were seen between diameter and consistency (r = 0.3) but there was little correlation between diameter and curvature (r = -0.13). A bivariate Cholesky analysis was used to estimate the genetic and environmental correlations between hair diameter and consistency, yielding genetic correlations of r gF = 0.27 for females and r gM = 0.25 for males.

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Biology of the Hair Follicle

Cited by 54 publications

References 74 publications

A Clinical and Investigatory Study of Alopecia Areata With Special Reference to Systemic Associations in 100 Patients

A Clinical and Investigatory Study of Alopecia Areata With Special Reference to Systemic Associations in 100 Patients

Alopecia areata update

Variation and Heritability in Hair Diameter and Curvature in an Australian Twin Sample

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