Biology of interleukin-38 and its role in chronic inflammatory diseases

Xia, Huasong; Liu, Yue; Fu, Yang Xin; Li, Meng; Wu, Yanqing

doi:10.1016/j.intimp.2021.107528

Cited by 17 publications

(24 citation statements)

References 41 publications

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“…IL-1F10 (IL-38) is known as a novel member of the IL-36 subfamily; [6] and its gene locates on chromosome 2q13-14.1 surrounded by IL-1 receptor (IL-1R) and IL-36R genes which act as a receptor antagonist [4]. IL-38 gene is involved in five exons that encode a 17-kDa molecular weight protein without N-and O-linked glycosylation sites and signal peptides [4,5]. Like other IL-1 family members, IL-38 needs N-terminal amputation for activation.…”

Section: Il-38 Structurementioning

confidence: 99%

“…Like other IL-1 family members, IL-38 needs N-terminal amputation for activation. Nonetheless, a protease that exerts to cut the N-terminal portion of IL-38 still is not determined [4,5]. Elaborate studies showed that IL-38 has 7 h halflife [3,4] and sequence analysis reported that IL-38 shares the highest protein homology with IL-36Ra and IL-1Ra, and lowest homology with IL-1β, respectively [3][4][5]7].…”

Section: Il-38 Structurementioning

confidence: 99%

“…Nonetheless, a protease that exerts to cut the N-terminal portion of IL-38 still is not determined [4,5]. Elaborate studies showed that IL-38 has 7 h halflife [3,4] and sequence analysis reported that IL-38 shares the highest protein homology with IL-36Ra and IL-1Ra, and lowest homology with IL-1β, respectively [3][4][5]7]. After elementary translation, IL-38 found as a soluble form releases two products: a large/major form consisting of 152 amino acids (molecular weight ~ 25 kDa), which could be the consequence of posttranslational alterations such as phosphorylation and a small/truncated form consisting of 133 amino acids with 17-kDa molecular weight.…”

Section: Il-38 Structurementioning

confidence: 99%

“…Cytokines with a poly-peptide nature act as signaling molecules that could amplify or alleviate immune responses besides their other biological functions [1,2]. is a new member of the IL-1 family that exhibited anti-inflammatory function in different autoimmune disorders [3,4], while there is controversy about its pro-inflammatory functions [4,5]. Regarding the pro-and anti-inflammatory properties of IL-38, studies describing the association between IL-38 and infections are little and its role in infectious diseases is not well understood yet.…”

Section: Introductionmentioning

confidence: 99%

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An overview of the biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19

et al. 2022

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Undoubtfully, the normal immune system can make a potential response to variable pathogens and neutralize or kill them depending on the type of infection through innate and acquired immunity. Cytokines have poly-peptide nature and are considered as signaling molecules that could amplify or alleviate immune responses besides their other biological functions. Interleukin 38 (IL-38) is a member of the IL-1 family cytokine that, however, its anti-inflammatory role has been observed in different autoimmune diseases like systemic lupus erythematosus (SLE), psoriasis, and Sjogren’s syndrome; there is a controversy about the cytokine pro-inflammatory function. In the current review, we skimmed IL-38 structure, signaling mechanism, and its immunological functions, IL-38-producing immune cells. Also, we argued about the role of this cytokine in viral infections including hepatitis B (HBV), hepatitis C (HCV), influenza (Flu), and COVID-19. Also, it illustrated the IL-38 protective effects on sepsis. Moreover, we explained the modulatory role of IL-38 in the COVID-19 cytokine storm.

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Section: Il-38 Structurementioning

confidence: 99%

Section: Il-38 Structurementioning

confidence: 99%

Section: Il-38 Structurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An overview of the biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19

et al. 2022

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“…Over the past few years, the tendency to investigate the immunobiological roles of IL-38 in immune-mediated diseases has matured [90], which is shown by the schematic presentation in Table 1.…”

Section: Role Of Il-38 In Immune-mediated Diseasesmentioning

confidence: 99%

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

Esmaeilzadeh

Bahmaie

Nouri

et al. 2021

IJMS

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Exponential growth in the usage of “cytokines” (as seroimmunobiomarkers) has facilitated more accurate prognosis, early diagnosis, novel, and efficient immunotherapeutics. Numerous studies have reported immunopathophysiological and immunopathological processes of interleukin-38 (IL-38). Therefore, in this systematic review article, the authors aimed to present an updated comprehensive overview on the immunobiological mechanisms, diagnostic, and immune gene-based therapeutic potentials of IL-38. According to our inclusion and exclusion criteria, a total of 216 articles were collected from several search engines and databases from the January 2012 to July 2021 time interval by using six main keywords. Physiologic or pathologic microenvironments, optimal dosage, and involved receptors affect the functionalities of IL-38. Alterations in serum levels of IL-38 play a major role in the immunopathogenesis of a wide array of immune-mediated disorders. IL-38 shows anti-inflammatory activities by reduction or inhibition of pro-inflammatory cytokines, supporting the therapeutic aspects of IL-38 in inflammatory autoimmune diseases. According to the importance of pre-clinical studies, it seems that manipulation of the immune system by immunomodulatory properties of IL-38 can increase the accuracy of diagnosis, and decipher optimal clinical outcomes. To promote our knowledge, more collaboration is highly recommended among laboratory scientists, internal/infectious diseases specialists, oncologists, immunologists, diseases-specific biomarkers scientists, and basic medical researchers.

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The emerging role of IL‐38 in diseases: A comprehensive review

Chen,

Xi,

et al. 2023

Immunity Inflam & Disease

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IntroductionInterleukin‐38 (IL‐38) is a new type of anti‐inflammatory cytokine, which is mainly expressed in the immunity‐related organs and is involved in various diseases including cardiovascular and cerebrovascular diseases, lung diseases, viral infectious diseases and autoimmune diseases.AimThis review aims to detail the biological function, receptors and signaling of IL‐38, which highlights its therapeutic potential in related diseases.ConclusionThis article provides a comprehensive review of the association between interleukin‐38 and related diseases, using interleukin‐38 as a keyword and searching the relevant literature through Pubmed and Web of science up to July 2023.

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Biology of interleukin-38 and its role in chronic inflammatory diseases

Cited by 17 publications

References 41 publications

An overview of the biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19

An overview of the biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19

Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic Review Study

The emerging role of IL‐38 in diseases: A comprehensive review

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