volume 22, issue 2, P217-234 2008
DOI: 10.1016/j.idc.2007.12.013
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Kit Tilly, Patricia A. Rosa, Philip E. Stewart

Abstract: The spirochete Borrelia burgdorferi is a tick-borne obligate parasite whose normal reservoir is a variety of small mammals [1]. Whereas infection of these natural hosts does not lead to disease, infection of humans can result in Lyme disease, as a consequence of the human immunopathological response to B. burgdorferi [2,3]. Consistent with the pathogenesis of Lyme disease, bacterial products that allow B. burgdorferi to replicate and survive, rather than true "virulence factors," appear to be primarily what i…

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