Biology of Hematopoietic Stem and Progenitor Cells

Manz, Markus G.; Akashi, Koichi

doi:10.1002/9780470987070.ch8

Cited by 8 publications

(8 citation statements)

References 359 publications

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“…To date, the only known treatment for hematopoietic failure is transplantation of bone marrow cells or HSCs [26]. But blood from the placenta and umbilical cord is a rich source of HSCs, too [27].…”

Section: Discussionmentioning

confidence: 99%

Effect of lung extract growth factors on the differentiation of umbilical cord stem cells into blood cells in vitro in adult mouse

Roodbari¹,

Kazem²,

Kouchesfahani³

et al. 2013

International Journal of Cellular and Molecular Biotechnology

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There are many diseases related to disorganized blood cells, especially erythrocytes and granulocytes. Therefore, it is important to find some methods for producing them. In this research work, we used extract of mouse lung to investigate the effects of its hematopoietic growth factors on stem cell differentiation in vitro. Stem cells were isolated from umbilical cord by enzyme digestion and cultured in an appropriate culture medium. In this study, four test groups were considered including experimental groups 1 & 2 (E1 & E2), which were exposed to 50% and 70% concentration of lung extract for 7 days, respectively, the sham (Sh) group, which was not exposed to lung extract, and the control (C) group, which were the same volume of mouse blood. E and Sh groups were incubated for 7 days. Mentioned groups were marked with alkaline phosphatase detection kit, their cells were counted and hematopoietic factors were measured. Morphological, cytological and differential examinations showed significant changes in E2 group as compared to the Sh group. E2 cells were differentiated into erythroid and myeloid lineages. These findings suggest that growth factors in lung extract (especially in E2) have progressive effects on umbilical cord stem cell differentiation into blood cells.

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Section: Discussionmentioning

confidence: 99%

Effect of lung extract growth factors on the differentiation of umbilical cord stem cells into blood cells in vitro in adult mouse

Roodbari¹,

Kazem²,

Kouchesfahani³

et al. 2013

International Journal of Cellular and Molecular Biotechnology

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“…In the bone marrow microenvironment, stem cells may remain quiescent for long periods of time until they are activated for the purpose of homeostasis or tissue repair (Manz et al, 2004). Inside the bone marrow reside long-term HSCs that have the capacity for self-renewal (see Figure 1).…”

Section: Stem Cell Biology the Hematopoietic Systemmentioning

confidence: 99%

“…As HSCs differentiate, they lose the CD34 marker and acquire other biochemical markers specific to a lineage. T cells will acquire CD4 or CD8 surface markers and B cells will acquire surface immunoglobulin markers and antigenspecific receptors (Manz et al, 2004). Table 2 summarizes the biochemical markers of the various blood cells.…”

Section: Stem Cell Biology the Hematopoietic Systemmentioning

confidence: 99%

“…The granulocyte-monocyte progenitor produces the granulocyte lineages (which produce neutrophils, basophils, and eosinophils), the monocyte-macrophage lineages, and the dendritic cell lineages. The megakaryocyte-erythrocyte progenitor produces the erythroid-lineage cells and megakaryocytes (Manz et al, 2004). Table 1 describes the function of each blood cell.…”

Section: Stem Cell Biology the Hematopoietic Systemmentioning

confidence: 99%

“…The developmental pathway of HSCs into functional blood cells involves loss of the potential to proliferate, with progressive differentiation into specific blood elements with defined functions. These fully differentiated blood cells have finite life spans, requiring constant renewal from the HSC pool (Manz, Akashi, & Weissman, 2004).…”

Section: Stem Cell Biology the Hematopoietic Systemmentioning

confidence: 99%

See 2 more Smart Citations

Mobilization of Hematopoietic Stem Cells for Use in Autologous Transplantation

Devine

Tierney²,

Schmit-Pokorny³

et al. 2010

Clinical Journal of Oncology Nursing

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Autologous hematopoietic stem cell transplantation (HSCT) is a potentially curative therapeutic approach for various malignant hematologic and lymphoid diseases. Hematopoietic stem cells (HSCs) may be collected from the blood or the bone marrow. HSCs are capable of self-renewal and give rise to progenitor cells, multipotent cells that differentiate and proliferate into the mature cells of the blood and immune system. HSCs and progenitor cells are released from the bone marrow into the peripheral blood through a process called mobilization. HSCs then are collected from the blood in a process called apheresis and cryopreserved for administration following the high-dose preparative regimen. This article reviews stem cell biology, current mobilization strategies, use of novel mobilization agents, and nursing care of patients during the mobilization phase of autologous HSCT. Understanding the biology and process of HSC mobilization is critical for transplantation nurses to deliver and coordinate care during this complex phase of autologous HSCT.

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Stem Cell Research

Weissman

2005

JAMA

135

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Biology of Hematopoietic Stem and Progenitor Cells

Cited by 8 publications

References 359 publications

Effect of lung extract growth factors on the differentiation of umbilical cord stem cells into blood cells in vitro in adult mouse

Effect of lung extract growth factors on the differentiation of umbilical cord stem cells into blood cells in vitro in adult mouse

Mobilization of Hematopoietic Stem Cells for Use in Autologous Transplantation

Stem Cell Research

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