Biology-guided engineering of bioelectrical interfaces

Miao, Bernadette A; Meng, Lingyuan; Tian, Bozhi

doi:10.1039/d1nh00538c

Cited by 5 publications

(2 citation statements)

References 146 publications

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“…Bioelectronic devices are an emerging technology that has achieved tremendous advances in electronic communications with biological systems. [101][102][103] In the past two decades, bioelectronic devices are being designed to be perfectly portable, implantable, and wearable for intelligent life support, recovery, and even human improvement. [104][105][106][107][108][109] Investigators are innovating materials, processing, and device design to dramatically optimize the performance of bioelectronic devices.…”

Section: Advanced Bioelectronic Devicesmentioning

confidence: 99%

Water-soluble conjugated polymers for bioelectronic systems

et al. 2023

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Section: Advanced Bioelectronic Devicesmentioning

confidence: 99%

Water-soluble conjugated polymers for bioelectronic systems

et al. 2023

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“…Biotic‐abiotic interfacing for device applications require consideration of the biocompatibility of abiotic systems, including toxicity, mechanical properties, ion concentration, etc. [ 17 , 154 , 155 ] Conductive polymers, such as PPy, polythiophenes, and PEDOT:PSS, demonstrate excellent biocompatible, suggesting their potential application in tissue engineering, biosensors, or development of electronic skin. [ 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 ] Sensing and converting electrical signals is one of the important biotic‐abiotic interfacing applications of electroactive materials in the biomedical space.…”

Section: Controlling Conduction Across Length Scales In Electrogenic ...mentioning

confidence: 99%

Engineering Multi‐Scale Organization for Biotic and Organic Abiotic Electroactive Systems

et al. 2023

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Multi-scale organization of molecular and living components is one of the most critical parameters that regulate charge transport in electroactive systems-whether abiotic, biotic, or hybrid interfaces. In this article, an overview of the current state-of-the-art for controlling molecular order, nanoscale assembly, microstructure domains, and macroscale architectures of electroactive organic interfaces used for biomedical applications is provided. Discussed herein are the leading strategies and challenges to date for engineering the multi-scale organization of electroactive organic materials, including biomolecule-based materials, synthetic conjugated molecules, polymers, and their biohybrid analogs. Importantly, this review provides a unique discussion on how the dependence of conduction phenomena on structural organization is observed for electroactive organic materials, as well as for their living counterparts in electrogenic tissues and biotic-abiotic interfaces. Expansion of fabrication capabilities that enable higher resolution and throughput for the engineering of ordered, patterned, and architecture electroactive systems will significantly impact the future of bioelectronic technologies for medical devices, bioinspired harvesting platforms, and in vitro models of electroactive tissues. In summary, this article presents how ordering at multiple scales is important for modulating transport in both the electroactive organic, abiotic, and living components of bioelectronic systems.

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Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

Zhang

Xie

Xing

et al. 2022

Adv Healthcare Materials

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Developing an ideal wound dressing that not only accelerates wound healing but also eliminates potential bacterial infections remains a difficult balancing act. This work reports the design of a light-programmable sodium alginate nanocomposite hydrogel loaded with BiOCl/polypyrrole (BOC/PPy) nanosheets for state-switchable wound healing promotion and bacterial infection elimination remotely. The nanocomposite hydrogel possesses programmable photoelectric or photothermal conversion due to the expanded light absorption range, optimized electron transmission interface, promoted photo-generated charge separation, and transfer of the BOC/PPy nanosheets. Under white light irradiation state, the nanocomposite hydrogel induces human umbilical vein endothelial cells migration and angiogenesis, and accelerates the healing efficiency of mouse skin in vivo. Under near-infrared light irradiation state, the nanocomposite hydrogel presents superior antibacterial capability in vitro, and reaches an antibacterial rate of 99.1% for Staphylococcus aureus infected skin wound in vivo. This light-programmable nanocomposite hydrogel provides an on-demand resolution of biological state-switching to balance wound healing and elimination of bacterial infection.

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Biology-guided engineering of bioelectrical interfaces

Abstract: This review provides an overview and recent advances of how biological systems guide the design, engineering, and implementation of bioelectrical interfaces for biomedical applications in nervous, cardiac, and microbial systems.

Cited by 5 publications

References 146 publications

Water-soluble conjugated polymers for bioelectronic systems

Water-soluble conjugated polymers for bioelectronic systems

Engineering Multi‐Scale Organization for Biotic and Organic Abiotic Electroactive Systems

Light‐Programmable Nanocomposite Hydrogel for State‐Switchable Wound Healing Promotion and Bacterial Infection Elimination

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