Biology – cancer metabolic phenotype

Čuperlović-Culf, Miroslava

doi:10.1533/9781908818263.15

Cited by 3 publications

(2 citation statements)

References 220 publications

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“…Sphingoid-based compounds as well as fatty acid amides like oleamide and arachidonoylethanolamide (NAE family) have been described with inhibitory effect on cell proliferation of various cancer cell lines and have been studied for the development of new therapies. 17,23,24 These results come to complete previous studies that reported anticancer activity of phlorotannins isolated from F. vesiculosus and other brown seaweeds. 25,26 Another metabolite that stands out in PCA was identified as glutathione (GSH) (Table 1).…”

Section: Resultssupporting

confidence: 73%

Untargeted metabolomic study of HepG2 cells under the effect of Fucus vesiculosus aqueous extract

André

Guedes

López³

et al. 2021

Rapid Comm Mass Spectrometry

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Bioisi MassSpec FacilityRationale: Fucus vesiculosus has been described with potential to develop functional foods containing bioactive compounds against various diseases. However, more studies are needed to better understand its functioning and its previously reported bioactivities, mainly at the molecular level.Methods: An untargeted metabolomic study was performed to analyse HepG2 cells exposed to F. vesiculosus aqueous extract, rich in phlorotannins and peptides, during 24 h. This study was carried out using liquid chromatography combined with highresolution tandem mass spectrometry.Results: This metabolomic study showed significant changes in HepG2 metabolites in the presence of the extract, standing out being the increased intensity of various fatty acid amides (oleamide, (Z)-eicos-11-enamide, linoleamide, palmitamide, dodecanamide and stearamide). This group of metabolites is reported in the literature with anticancer and hypocholesterolemic activity, bioactivities also described for F. vesiculosus. The extract induced, likewise, the expression of glutathione indicating its antioxidant effect.Conclusions: This study demonstrated the potential of the compounds present in the F. vesiculosus aqueous extract for the development of natural drugs, nutraceuticals or dietary supplements, justified at the molecular level by changes in cell metabolites related to anticancer and hypocholesterolemic activity. The results here described, using an untargeted metabolomic approach, may contribute to a better understanding of algal behaviour, when used as food, in health-promoting effects.

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Section: Resultssupporting

confidence: 73%

Untargeted metabolomic study of HepG2 cells under the effect of Fucus vesiculosus aqueous extract

André

Guedes

López³

et al. 2021

Rapid Comm Mass Spectrometry

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“…It increases the expression of many glycolytic enzymes, including HK2, triose-phosphate isomerase (TPI), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), leading to upregulation of the overall rate of glycolysis [18,19]. Moreover, it increases the expression of the glucose transporter (GLUT1 and GLUT3), to uptake more glucose [20,21]. Moreover, HIF-1α, by affecting pyruvate dehydrogenase kinase 1 (PDK1), results in the inhibition of pyruvate dehydrogenase (PDH).…”

Section: Macrophagesmentioning

confidence: 99%

Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity

Mohammadnezhad

Azgomi

Manna

et al. 2022

Cells

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Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.

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Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Large

Abdelmessih

Fink

et al. 2021

Advanced Drug Delivery Reviews

437

259

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Biology – cancer metabolic phenotype

Cited by 3 publications

References 220 publications

Untargeted metabolomic study of HepG2 cells under the effect of Fucus vesiculosus aqueous extract

Untargeted metabolomic study of HepG2 cells under the effect of Fucus vesiculosus aqueous extract

Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

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