Biology and Diseases of Swine

Laber, Kathy; Whary, Mark T.; Bingel, Sarah A.; Goodrich, James A.; Smith, Alison C.; Swindle, M. Michael

doi:10.1016/b978-012263951-7/50018-1

Cited by 25 publications

(26 citation statements)

References 188 publications

(114 reference statements)

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“…In addition, the stomach of pigs has a muscular outpouching of uncertain function termed the torus pyloricus, in the pyloric region near the gastro-duodenal junction (29,(52)(53). This outpouching is not present in the human stomach.…”

Section: Comparative Gastrointestinal Tract Anatomy Of Pigs and Humansmentioning

confidence: 95%

The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

Patterson

Lei²,

Miller³

2008

Exp Biol Med (Maywood)

219

178

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Section: Comparative Gastrointestinal Tract Anatomy Of Pigs and Humansmentioning

confidence: 95%

The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

Patterson

Lei²,

Miller³

2008

Exp Biol Med (Maywood)

219

178

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“…The most common routes of infection are via the ingestion of contaminated food or water and skin wounds (Laber et al., 2002). Pigs between 3 months and 3 years old are most susceptible to erysipelas (Wood and Henderson, 2006), and there is evidence to suggest that environmental and stress factors can predispose animals to the disease.…”

Section: Introductionmentioning

confidence: 99%

Outbreak of Swine Erysipelas in a Semi-Intensive Wild Boar Farm in Spain

Risco¹,

Llario²,

Velarde

et al. 2011

Transboundary and Emerging Diseases

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Swine erysipelas (SE) is a disease caused by the bacterium Erysipelothrix rhusiopathiae and is one of the best-known and most serious diseases affecting domestic pigs. However, few studies exist concerning the susceptibility of wild boars to this disease and the role of this species as a reservoir. This study investigates and describes an outbreak of SE that occurred on a semi-intensive wild boar breeding farm housing 40 boars in Extremadura (SW Spain) on 11-18 February 2010. Seven animals died, of which four were examined post-mortem. Of these, three (two females and one male) were approximately 3 months old, and one was 1 year old (male). Lesions were consistent with acute septicaemia, consisting of cutaneous erythema/cyanosis and petechial haemorrhages in kidneys, urinary bladder, lungs and meninges. The 1-year-old male also had proliferative polyarthritis. Histopathology confirmed the presence of disseminated intravascular coagulation and vasculitis. Additionally, a bilateral acute panuveitis with concurrent necrotizing vasculitis and diffuse corneal oedema, neither of which have been described before in this disease, were found in the 3-month-old male boar. E. rhusiopathiae was isolated from all four animals in pure cultures from several tissues. Of these four animals, antibodies against E. rhusiopathiae, using an indirect ELISA test, were only detected in the 1-year-old male boar with polyarthritis. Posteriorly, of nine live adults tested for antibodies, four (including an adult male with polyarthritis) were positive.

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“…They are intelligent, emotional animals and, when handled and housed correctly, aggression problems are less likely encountered. (112)(113)(114)(115)(116)(117)(118)(119) The ease of handling reduced size livestock has definite advantages in terms of space requirements and reduced housing and food costs. Benefits extend to include reduced bone scan times, smaller size samples for analysis, and the smaller quantity of drugs required to elicit therapeutic effects.…”

Section: Pigsmentioning

confidence: 99%

“…However, occasional human-directed aggression is a docu-mented problem in pet miniature pigs, (116) as is obesity if food intake is not regulated. (117) The most commonly used breeds of miniature pigs in laboratory research are Yucatan miniature and micropigs, Hanford, Sinclair, and Gottingen pigs. (118) By nature, pigs are socially inclined and quickly establish dominance hierarchies within groups.…”

Section: Pigsmentioning

confidence: 99%

Review of Nonprimate, Large Animal Models for Osteoporosis Research

Reinwald

Burr

2008

Journal of Bone and Mineral Research

127

101

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Large animal models are required for preclinical prevention and intervention studies related to osteoporosis research. The challenging aspect of this requirement is that no single animal model exactly mimics the progression of this human-specific chronic condition. There are pros and cons associated with the skeletal, hormonal, and metabolic conditions of each species that influence their relevance and applicability to human physiology. Of all larger mammalian species, nonhuman primates (NHPs) are preeminent in terms of replicating important aspects of human physiology. However, NHPs are very expensive, putting them out of reach of the vast majority of researchers. Practical, cost-effective alternatives to NHPs are sought after among ungulate (porcine, caprine, and ovine) and canine species that are the focus of this review. The overriding caveat to using large lower-order species is to take the time in advance to understand and appreciate the limitations and strengths of each animal model. Under these circumstances, experiments can be strategically designed to optimize the potential of an animal to develop the cardinal features of postmenopausal bone loss and/or yield information of relevance to treatment.

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Biology and Diseases of Swine

Cited by 25 publications

References 188 publications

The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption

Outbreak of Swine Erysipelas in a Semi-Intensive Wild Boar Farm in Spain

Review of Nonprimate, Large Animal Models for Osteoporosis Research

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