Biology and Diseases of Mice

Whary, Mark T.; Baumgarth, Nicole; Fox, James G.; Barthold, Stephen W.

doi:10.1016/b978-0-12-409527-4.00003-1

Cited by 68 publications

(69 citation statements)

References 317 publications

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“…Full blood counts on WT and FAP GKO mice showed no difference in platelet numbers or any other major blood cell type (supplemental Table S18), which is consistent with the initial description of this mouse strain (24,65).…”

Section: Molecular and Cellular Proteomics 181 71supporting

confidence: 83%

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

Zhang¹,

Hamson²,

Koczorowska³

et al. 2019

Molecular & Cellular Proteomics

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Fibroblast activation protein-␣ (FAP) can hydrolyze the postproline bond. We identified endogenous substrates of FAP in fibroblasts that were previously naive to both FAP and its proteolytic activity. FAP-dependent cleavage sites were identified in many extracellular matrix (ECM) and ECM-associated proteins including collagens and lysyl oxidase-like-1, and CSF-1, CXCL-5 and C1qT6. Quantitative proteomic analysis implicated FAP in ECM-cell interactions, coagulation and metabolism. This study greatly expands the repertoire of FAP substrates and shows that FAP has a role in coagulation in the mouse.

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Section: Molecular and Cellular Proteomics 181 71supporting

confidence: 83%

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

Zhang¹,

Hamson²,

Koczorowska³

et al. 2019

Molecular & Cellular Proteomics

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“…They live in social groups called demes that are composed of a dominant breeding male, a hierarchy of females, subordinate males and juveniles. This results in a high degree of inbreeding which, combined with their high mutation rates, contributes to their ability to adapt quickly to environmental changes (3, 4). Mice are omnivorous, nocturnal, adapt well to temperature extremes, and with their ability to jump and chew through small openings, they are well poised to take advantage of human food sources in fields, homes and granaries (5).…”

Section: Mouse Natural Historymentioning

confidence: 99%

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

Masopust

Sivula

Jameson

2017

The Journal of Immunology

214

172

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Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a ‘dirty’ mouse model that better mimics the diverse infectious history that is typical of most humans.

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“…The eggs are deposited at night and are excreted in a mucous layer, covering faecal pellets. They embryonate in the environment, where they require 6-7 days at 24°C to become infective and, subsequently, can survive for weeks (WHARY et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…In animals, light infestation is usually subclinical, although high parasite loads can cause decreased activity, weight loss and occasionally also intestinal lesions, including rectal prolapse, intussusception, enteritis, rectal irritation with self-mutilation and faecal impaction (HEATLEY & HARRIS, 2008;WHARY et al, 2015). In addition to the negative influence on the health of animals, the zoonotic potential of some members of the Oxyuridae family has also been confirmed.…”

Section: Introductionmentioning

confidence: 99%

Oxyurid nematodes of pet rodents in Slovakia - a neglected zoonotic threat

Jarošová

Antolová

Zaleśny

et al. 2020

Rev. Bras. Parasitol. Vet.

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The role of rodents as reservoirs of helminths of public health importance is not well known. The zoonotic potential of Syphacia spp. has been confirmed; therefore, the study aimed to estimate the occurrence of oxyurid nematodes in small rodents from pet shops and breeding clubs in Slovakia. Fecal samples of 586 pet rodents kept in 133 cages were collected between 2016 and 2018 and examined by Faust´s flotation method. Four species of oxyurid nematodes, Syphacia muris, S. obvelata, Aspiculuris tetraptera and Paraspidodera uncinata were detected. A. tetraptera was found in the faecal samples of all rodent species included in this survey. The number of positive boxes varied from 5.4% in hamsters to 70.0% with mice. The prevalence of Syphacia muris was highest in Mongolian gerbils where up to 75.0% boxes were positive; S. obvelata was found in 26.7% of boxes with mice, 25.0% of boxes with Mongolian gerbils and 3.2% of boxes with rats. The high prevalence of Syphacia spp. in all animal species points out the infection risk for humans. Animals offered for sale are often in close contact with human beings; therefore they should be regularly tested for parasites and then effectively dewormed.

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Biology and Diseases of Mice

Cited by 68 publications

References 317 publications

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

Oxyurid nematodes of pet rodents in Slovakia - a neglected zoonotic threat

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