Biologically relevant tetraazamacrocyclic complexes of manganese: synthetic, spectral, antimicrobial, antifertility and antiinflammatory approach

Journal of Enzyme Inhibition and Medicinal Chemistry

2009

A new series of complexes is synthesized by template condensation of oxalyldihydrazide and glyoxal in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type:3 , CH 3 COO 21 . The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, NMR, infrared and far infrared spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry for these complexes has been proposed. The biological activities of the metal complexes were tested in vitro against a number of pathogenic bacteria and some of the complexes exhibited remarkable antibacterial activities.

Section: Introductionmentioning

confidence: 99%

Antibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal

Journal of Enzyme Inhibition and Medicinal Chemistry

2009

“…The chemistry of macrocyclic complexes is also important due to their use as dyes and pigments [13] as well as NMR shift reagents [14]. Macrocyclic complexes are also well known for their antibacterial and antifungal activities [15,16]. Most of the macrocyclic metal chelates have been derived from aliphatic or aromatic diamines and aliphatic or aromatic diketones.…”

Section: Introductionmentioning

confidence: 99%

Template synthesis, spectroscopic studies and biological activities of macrocyclic complexes derived from thiocarbohydrazide and glyoxal

Journal of Enzyme Inhibition and Medicinal Chemistry

Malik

et al. 2007

A novel series of complexes of the type [M(TML)X 2 ]; where TML is Tetradentate Macrocyclic Ligand; M ¼ Co(II), Ni(II), Cu(II), Zn(II)or Cd(II); X ¼ Cl 2 , CH 3 COO 2 or NO 2 3 have been synthesized by template condensation of glyoxal and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest a six coordinate octahedral geometry for these complexes. The low molar conductance values indicates them to be non-electrolytes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibitory potential.

“…The importance of macrocyclic complexes in coordination chemistry is because of its various applications in biological processes such as photosynthesis and dioxygen transport along with catalytic properties and potential applications as metal extractants and radio therapeutic agents [10]. Some macrocyclic complexes have been reported to show antifertility, antifungal and antibacterial activities [11,12] while some others show an anti-inflammatory approach [13]. Several macrocyclic complexes with tetraazamacrocyclic ligands, such as cyclen, cyclam or bicyclam were reported to exhibit antitumour activity [14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with macrocycle 3,4,11,12-tetraoxo-1,2,5,6,9,10,13,14-octaaza-cyclohexadeca-6,8,14,16-tetraene and their biological screening

Malik

et al. 2007

Transition Met Chem

114

A new series of complexes is synthesized by template condensation of glyoxal and oxalyldihydrazide in methanolic medium in the presence of divalent cobalt, nickel, copper, zinc and cadmium salts forming complexes of the type:3 ; OAc À1 . The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, n.m.r., infrared and far infrared spectral studies. On the basis of these studies, a six coordinate octahedral geometry for these complexes has been proposed. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. Most of the compounds have been found to exhibit remarkable antibacterial activities.