Biologically Coupled Gate Field-Effect Transistors Meet <i>in Vitro</i> Diagnostics

Sakata, Toshiya

doi:10.1021/acsomega.9b01629

Cited by 58 publications

(45 citation statements)

References 82 publications

(210 reference statements)

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“…Ion-sensitive field-effect transistors (ISFETs) and light-addressable potentiometric sensors are beyond the scope of the present review. It should be noted that biosensors based on biologically coupled ISFETs have been advanced a lot and made important contributions to the field of potentiometric biosensing [63]. For example, pH-sensitive ISFETs were designed to directly perform DNA sequencing of genomes [64,65] and detect antigen-antibody reactions [66].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in potentiometric biosensors

Ding

Qin

2020

TrAC Trends in Analytical Chemistry

194

109

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Potentiometry based on ion-selective electrodes (ISEs) has been injected with new vigor and gone through a renaissance with the improvements in the detection limits and selectivities of ISEs, the introduction of new materials, new sensing concepts (from conventional potentiometry to dynamic electrochemistry approaches), and deeper theoretical understanding and modelling of the potentiometric responses of ISEs. The new breakthroughs encourage innovations in ion sensing and biosensing applications. Moreover, with the introduction of new bioreceptors, such as enzymes, antibodies, aptamers, peptides, versatile sensing protocols have been designed for a broad range of different target molecules by using ISEs as powerful transducers. This paper reviews the recent trends in potentiometric biosensors. Their applications in biosensing of metal ions, small molecules, DNA, proteins, bacteria and toxicities have been discussed. This review provides the outlook of the potentiometric biosensing based on the integration of potentiometric ISEs with new materials and emerging techniques.

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Section: Introductionmentioning

confidence: 99%

Recent advances in potentiometric biosensors

Ding

Qin

2020

TrAC Trends in Analytical Chemistry

194

109

View full text Add to dashboard Cite

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“…In the most recent couple of years, an ISFET sensor with oxide-electrolyte structure has been used for cell analysis and pH measurements. A SiO 2 -Ta 2 O 5 oxide gated ISFET was used for live-cell monitoring by measuring the pH variations around cells on the gate [ 60 , 61 ]. In another attempt, Si 3 N 4 /Ta 2 O 5 oxide gated ISFET was used for studying the self-assembly of photosynthetic proteins [ 62 ].…”

Section: Sensing Mechanism and Different Structures Of Chem/biofetsmentioning

confidence: 99%

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

et al. 2021

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Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). The COVID-19 pandemic, nevertheless, was an example of the escalated situation in terms of worldwide desperate need for fast, specific and reliable home test PoC devices for the timely screening of huge numbers of people to restrict the disease from further spread. This need spawned a wave of innovative approaches for early detection of COVID-19 antibodies in human swab or blood amongst which the FET biosensing gained much more attention due to their extraordinary LoD down to femtomolar (fM) with the comparatively faster response time. As the FET sensors are promising novel PoC devices with application in early diagnosis of various diseases and especially infectious diseases, in this research, we have reviewed the recent progress on developing FET sensors for infectious diseases diagnosis accompanied with a thorough discussion on the structure of Chem/BioFET sensors and the readout circuitry for output signal processing. This approach would help engineers and biologists to gain enough knowledge to initiate their design for accelerated innovations in response to the need for more efficient management of infectious diseases like COVID-19.

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“…In FET-based biosensors, the gate terminal and/or the dielectric layer are modified with specific bioreceptors (antibodies, oligonucleotides, peptides, receptors, cells, enzymes, aptamers, etc.) to capture desired bio/chemical molecules [ 28 , 29 , 30 ]. When target bio/chemical molecules bind with bioreceptors, surface charges result in modulation of the electrical characteristics of FET devices.…”

Section: Fet Platform: General Featuresmentioning

confidence: 99%

Non-Carbon 2D Materials-Based Field-Effect Transistor Biosensors: Recent Advances, Challenges, and Future Perspectives

Sedki

Chen

Mulchandani

2020

Sensors

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In recent years, field-effect transistors (FETs) have been very promising for biosensor applications due to their high sensitivity, real-time applicability, scalability, and prospect of integrating measurement system on a chip. Non-carbon 2D materials, such as transition metal dichalcogenides (TMDCs), hexagonal boron nitride (h-BN), black phosphorus (BP), and metal oxides, are a group of new materials that have a huge potential in FET biosensor applications. In this work, we review the recent advances and remarkable studies of non-carbon 2D materials, in terms of their structures, preparations, properties and FET biosensor applications. We will also discuss the challenges facing non-carbon 2D materials-FET biosensors and their future perspectives.

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Biologically Coupled Gate Field-Effect Transistors Meet in Vitro Diagnostics

Cited by 58 publications

References 82 publications

Recent advances in potentiometric biosensors

Recent advances in potentiometric biosensors

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

Non-Carbon 2D Materials-Based Field-Effect Transistor Biosensors: Recent Advances, Challenges, and Future Perspectives

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