Biologically active sesquiterpene coumarins fromFerulaspecies

Abstract

Extracts from different species of the genus Ferula (Apiaceae) have had various biomedical applications for many centuries. Many biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety. This both highlights the importance of sesquiterpene coumarins as biologically active natural products and necessitates further studies on these compounds. Taking into account the versatile biological properties of compounds isolated from Ferula and the unprecedented interest in the application of natural products as a new generation of therapeutics, the present review will discuss reports on biological activities of sesquiterpene coumarins of the genus Ferula, from 1990 onwards.

Synthesis, biosynthesis and biological activities of galbanic acid – A review

“…Galbanic acid (GA) and its ester, methyl galbanate, are natural products belonging to the class sesquiterpene coumarins (Figure 1) (Nazari & Iranshahi, 2011). Sesquiterpene coumarins mostly occur in the genus Ferula (Apiaceae), particularly F. galbaniflua Boiss.…”

“…& Buhse. These compounds have shown various biological activities including anti-inflammatory, antitumor, cytotoxic, and antiviral activities (Gliszczyńska & Brodelius, 2012;Iranshahy & Iranshahi, 2011;Nazari & Iranshahi, 2011). Among the sesquiterpene coumarins, GA has drawn special attention for its promising biological activities.…”

The Effect of Ajwain (Trachyspermum ammi) Extracted by Ultrasound-Assisted Solvent on Quality Properties of Silver Carp (Hypophthalmichthys molitrix) Surimi Stored at 4C

“…The major protective effect of ajwain by UAS extract is referred to phenolic compounds particularly thymol content Kavoosi and Rowshan (2013) and Nazari and Iranshahi (2011) reported that antioxidant activities may be attributed to the presence of phenols, flavonoids, sesquiterpenes and sulfur-containing compounds in the ajwain. Such antioxidant activities could diminish oxidative damage in foodstuff (Nazari and Iranshahi 2011;Kavoosi and Rowshan 2013).…”

Untitled

“…These results were in line with a previous study in which the data exhibited that the absolute methanol have a greater yield than ethanol. [37] Some study also exhibited the aqueous and alcoholic extracts tested for in vitro cytotoxicity study. [38] The result showed that aqueous extracts were considered to be less cytotoxic to these cells than their alcoholic extracts of the species.…”