Biologically Active Coordination Compounds of Germanium. Synthesis and Physicochemical Properties

Kadomtsevа, A. V.; Мочалов, Г. М.; Kuzina, O. V.

doi:10.1134/s1070428021060026

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…This review specifically focuses on the latest research conducted within the past decade, during which inorganic and coordination compounds of germanium have been incorporated into medical practices alongside water-soluble organic germanium compounds [3,45,46].…”

Section: Of 19mentioning

confidence: 99%

“…The inorganic and coordination germanium compounds are now well established in medical practice (see reviews [3,149,150] and monograph [46]). The structure of such compounds is discussed in detail in the review [151].…”

Section: Inorganic and Coordination Germanium Compoundsmentioning

confidence: 99%

“…Among coordination germanium compounds, the most studied are germanium (IV) citrate and germanium (IV) citrate-lactate, which, like GeO2, are of low toxicity but exhibit nephrotoxicity in high doses [6,47,58]. These compounds activate the immune system and are recommended for the treatment of a wide range of diseases, primarily oncological [3,43,46,149,150,153].…”

Section: Inorganic and Coordination Germanium Compoundsmentioning

confidence: 99%

“…Currently, germanium is widely recognized as a vital trace element, in particular it is essential for the normal functioning of the immune system and playing a significant role in cancer prevention [1][2][3][4][5][6][7]. Germanium is ubiquitously present in mammalian organs and tissues, with the highest concentration in the thymus.…”

Section: Introductionmentioning

confidence: 99%

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Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков¹,

Popov²

2023

Preprint

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and hushed up for a long time.

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Section: Of 19mentioning

confidence: 99%