Biological variation and reference change values of common clinical chemistry and haematologic laboratory analytes in the elderly population

Pineda‐Tenor, Daniel; Laserna-Mendieta, Emilio J; Timón-Zapata, Jesús; Rodelgo-Jiménez, Laura; Ramos-Corral, Raquel; Recio-Montealegre, Antonio; Reus, Manuel

doi:10.1515/cclm-2012-0701

Cited by 45 publications

(26 citation statements)

References 36 publications

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“…Data in Table 1 are ordered according the author and publication; also the reference numbers are shown [10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Resultsmentioning

confidence: 99%

Biological variation database: structure and criteria used for generation and update

Perich¹,

Minchinela²,

Ricós³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Data in Table 1 are ordered according the author and publication; also the reference numbers are shown [10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Resultsmentioning

confidence: 99%

Biological variation database: structure and criteria used for generation and update

Perich¹,

Minchinela²,

Ricós³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…The study design (number of subjects, samples from each subject, and number of replicates) has a great impact on the reliability with which we can estimate the BV data and on the confidence intervals (CI) for the calculated CVs. There are a few published papers reporting BV data calculated from a large numbers of subjects [22][23][24][25][26]. Those studies involve a low number of collections from each subject (from four to six), often with measurements performed in singleton on the day of the collection.…”

Section: Post-analytical Phasementioning

confidence: 99%

Sample collections from healthy volunteers for biological variation estimates’ update: a new project undertaken by the Working Group on Biological Variation established by the European Federation of Clinical Chemistry and Laboratory Medicine

Carobene

Strollo

Jonker

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…[39] As a consequence, the study cannot assess a preference of population-based reference intervals over intraindividual reference changing values. [7] External validity is impaired by the fact that the investigated cohort consists entirely of participants with Caucasian descent. As a consequence, the evaluated reference intervals might not be extrapolated to persons with other racial backgrounds.…”

Section: Discussionmentioning

confidence: 99%

“…[5–7] These reference intervals are most often obtained from investigations in healthy adult persons aged <60 years. [8,9] Although elderly persons sometimes are regarded as elderly versions of adults, from a physiopathological viewpoint, seniors—analogously to children—have their distinct own biology.…”

Section: Introductionmentioning

confidence: 99%

Seniorlab

2017

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Background:In clinical practice, laboratory results are often important for making diagnostic, therapeutic, and prognostic decisions. Interpreting individual results relies on accurate reference intervals and decision limits. Despite the considerable amount of resources in clinical medicine spent on elderly patients, accurate reference intervals for the elderly are rarely available. The SENIORLAB study set out to determine reference intervals in the elderly by investigating a large variety of laboratory parameters in clinical chemistry, hematology, and immunology.Methods/design:The SENIORLAB study is an observational, prospective cohort study. Subjectively healthy residents of Switzerland aged 60 years and older were included for baseline examination (n = 1467), where anthropometric measurements were taken, medical history was reviewed, and a fasting blood sample was drawn under optimal preanalytical conditions. More than 110 laboratory parameters were measured, and a biobank was set up. The study participants are followed up every 3 to 5 years for quality of life, morbidity, and mortality. The primary aim is to evaluate different laboratory parameters at age-related reference intervals. The secondary aims of this study include the following: identify associations between different parameters, identify diagnostic characteristics to diagnose different circumstances, identify the prevalence of occult disease in subjectively healthy individuals, and identify the prognostic factors for the investigated outcomes, including mortality.Discussion:To obtain better grounds to justify clinical decisions, specific reference intervals for laboratory parameters of the elderly are needed. Reference intervals are obtained from healthy individuals. A major obstacle when obtaining reference intervals in the elderly is the definition of health in seniors because individuals without any medical condition and any medication are rare in older adulthood. Reference intervals obtained from such individuals cannot be considered representative for seniors in a status of age-specific normal health. In addition to the established methods for determining reference intervals, this longitudinal study utilizes a unique approach, in that survival and long-term well-being are taken as indicators of health in seniors. This approach is expected to provide robust and representative reference intervals that are obtained from an adequate reference population and not a collective of highly selected individuals.Trial registration:The present study was registered under International Standard Randomized Controlled Trial Number registry: ISRCTN53778569.

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Biological variation and reference change values of common clinical chemistry and haematologic laboratory analytes in the elderly population

Cited by 45 publications

References 36 publications

Biological variation database: structure and criteria used for generation and update

Biological variation database: structure and criteria used for generation and update

Sample collections from healthy volunteers for biological variation estimates’ update: a new project undertaken by the Working Group on Biological Variation established by the European Federation of Clinical Chemistry and Laboratory Medicine

Seniorlab

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