Biological therapy of salivary duct carcinoma

Nashed, Mona; Casasola, Richard

doi:10.1017/s0022215108002314

Cited by 77 publications

(39 citation statements)

References 13 publications

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“…The 2 patients are still alive at the time of writing, 13 and 33 months, respectively, since the date of diagnosis. Their survival is within the range previously described for reported cases of patients with SDC treated with trastuzumab (13,31,32).…”

Section: Discussionsupporting

confidence: 83%

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Detection of Novel Actionable Genetic Changes in Salivary Duct Carcinoma Helps Direct Patient Treatment

Nardi

Sadow

Juric

et al. 2013

Clinical Cancer Research

105

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Purpose: Salivary duct carcinomas (SDC) are a rare and aggressive subtype of salivary gland cancers for which cytotoxic chemotherapy has limited efficacy. We investigated whether genotyping analysis could detect novel tumor-specific mutations that would help direct SDC patient treatment using targeted agents.Experimental Design: We genotyped 27 SDC archival specimens from patients followed at Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary (Boston, MA) between 2000 and 2011. These included the tumors of 8 patients who were tested prospectively. Targeted mutational analysis of 13 clinically relevant cancer genes was conducted using SNaPshot multiplexed genotyping. FISH was conducted to detect HER2 gene amplification. Patient medical records and tumor histopathologic features were retrospectively reviewed.Results: Mutually exclusive genetic aberrations were detected in 15 of 27 (56%) tumors, including 2 (7%) mutations in BRAF, 5 (19%) mutations in PIK3CA, and 8 (30%) cases of HER2 gene amplification. To our knowledge, this is the first time that BRAF and PIK3CA mutations have been reported in this tumor type. Prospective clinical testing of 8 patients with SDC identified actionable genetic alterations in 6 tumors and influenced therapeutic decisions for all 6 patients.Conclusion: SNaPshot molecular profiling identified novel genetic changes in SDCs, expanded the therapeutic options for patients with this rare tumor, and is changing SDC management at our institution. These findings highlight the importance of using broad-based genetic profiling to expedite the identification of effective-targeted therapies for patients with rare malignancies. Clin Cancer Res; 19(2); 480-90. Ó2012 AACR.

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Section: Discussionsupporting

confidence: 83%

“…These findings provide a rationale for exploring the effects of trastuzumab in the treatment of HER2-positive SDC. So far, only few patients with SDC have been enrolled in treatment regimens that included HER2 antagonists, and some case reports have shown encouraging results with an occasional complete response (13,25,31,32).…”

Section: Discussionmentioning

confidence: 99%

Detection of Novel Actionable Genetic Changes in Salivary Duct Carcinoma Helps Direct Patient Treatment

Nardi

Sadow

Juric

et al. 2013

Clinical Cancer Research

105

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“…A number of previous studies demonstrated that HER-2/neu and p53 expression are statistically associated with SDC survival rates (3,(15)(16)(17)(18)(19)(20). However, in the present study, the protein expression levels of HER-2/neu, AR, Ki-67, p16 and p53 did not correlate with prognosis, although HER-2/neu, AR and p16 demonstrated a positive expression rate of >50%, which may contribute to the diagnosis for SDC.…”

Section: A B C D Econtrasting

confidence: 80%

“…Due to the limited efficacy and severe complications of surgery and radiotherapy, a more systematic therapeutic approach should be analyzed in order to improve the prognosis of SDC. The present study demonstrated a high positivity rate for HER-2/neu and AR expression in SDC, indicating that SDC carcinogenesis may resemble that of breast ductal carcinoma or prostate cancer (4,7,11,13,15,18,21,22). As HER-2/neu blockers (trastuzumab) are effective in treating HER-2-overexpressing breast cancer, this agent may be useful for the treatment of SDC.…”

Section: A B C D Esupporting

confidence: 49%

“…Similarly, androgen deprivation therapy may be applied to the treatment of SDC. These two therapeutic strategies have achieved positive results in a small number of cases of head and neck SDC (11,15,22). Clinicians may expect monoclonal antibody treatments to be a promising adjuvant therapy for SDC, however, this field requires additional research prior to the application of such therapies.…”

Section: A B C D Ementioning

confidence: 99%

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Salivary duct carcinoma: A clinopathological report of 11 cases

et al. 2015

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Abstract. The aim of the present study was to summarize the clinicopathological and immunohistochemical characteristics of salivary duct carcinoma (SDC) and to evaluate the currently available treatment modalities. Between 2001 and 2011, 11 patients with SDC were diagnosed and treated at the Affiliated Hospital of Stomatology of Nanjing University (Nanjing, Jiangsu, China). The present study retrospectively reviewed the clinicopathological and immunohistochemical data of these 11 patients and the results indicated that the parotid gland was the most commonly affected site, followed by the submandibular gland and the palate. Furthermore, the mean age of onset was 58.8 years and all cases were treated with surgery, with 72.7% receiving post-operative radiation therapy. The range for the follow-up period was 10-89 months and of the 11 patients investigated, only two succumbed to the disease. In addition, the two-year overall survival rate was 75% according to Kaplan-Meier analysis and the mean overall survival time was 72.8 months. In conclusion, the present study determined that the site of the malignancy is the best predictor of survival in patients with the rare salivary malignancy SDC, while age, gender, T stage, N stage, American Joint Committee on Cancer stage, nerve paralysis, post-operative radiation, neck dissection, and protein expression levels of Ki-67, androgen receptor and human epidermal growth factor-2/neu are less influential factors. IntroductionSalivary duct carcinoma (SDC) is a rare type of salivary malignancy which accounts for <10% of all salivary malignancies, and the majority of its histological characteristics are similar to those of mammary duct carcinoma (1-3). SDC exhibits characteristic ductal lesions and tumor cells are often arranged in a 'Roman bridge' formation and cribriform architecture, with comedo necrosis (2). Due to the rarity of SDC, little data regarding its clinicopathological characteristics exists. The standard treatment for SDC is surgery in combination with radiotherapy, however, the prognosis of SDC is poor (4-7). Effective therapeutic strategies rely on a sufficient understanding of SDC and its prognostic factors, therefore, the aim of the present retrospective study was to summarize the clinicopathological characteristics of SDC and to evaluate the current treatment modalities currently used at the Affiliated Hospital of Stomatology of Nanjing University (Nanjing, Jiangsu, China). (2), were identified at the Affiliated Hospital of Stomatology. Subsequent to excluding any patients with distant metastasis or a previous history of head-neck surgery, all 11 patients primarily underwent surgical treatment, predominantly consisting of local extensive resection with neck dissection, followed by post-operative radiation therapy. All cases were followed up from the date of the surgical procedure to the date of mortality or the date patients were lost to follow-up. Clinical and histological data were reviewed (Table I). Patients and methods PatientsStatistical analysis. All d...

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