Outcomes of Postoperative Concurrent Chemoradiotherapy for Locally Advanced Major Salivary Gland Carcinoma

Abstract

Locally advanced or high-grade salivary gland carcinomas follow an aggressive clinical course. Based on our limited experience, postoperative chemoradiation with a platinum-based regimen seems to be effective in selected patients and warrants further investigation.

Pediatric Salivary Cancer: Epidemiology, Treatment Trends, and Association of Treatment Modality with Survival

“…This finding adds to a conflicting body of evidence on the effects of RT on pediatric salivary malignancies 18,20,40 . RT has a clear survival benefit in adult salivary malignancies with a variety of risk factors, and some evidence suggests that this benefit holds for pediatrics 5,41‐47 . Our findings of a survival benefit of adjuvant RT conflict with those of Radomski et al, 3 who found worse outcomes following the use of adjuvant RT.…”

“…18,20,40 RT has a clear survival benefit in adult salivary malignancies with a variety of risk factors, and some evidence suggests that this benefit holds for pediatrics. 5,[41][42][43][44][45][46][47] Our findings of a survival benefit of adjuvant RT conflict with those of Radomski et al, 3 who found worse outcomes following the use of adjuvant RT. However, the authors did not control for a variety of critical factors in that analysis, including cancer stage and tumor grade.…”

Reirradiation of recurrent salivary gland malignancies with fractionated stereotactic body radiation therapy

“…A number of phase I and II trials have investigated systemic therapy with mixed results [16]. Recently, concurrent chemoradiation has been shown to improve LRC and PFS in retrospective series [7, 17, 18]. In our series, no statistically significant correlation was seen on either univariate or multivariate analysis perhaps due to the fact that only 39% of the patients received chemotherapy.…”

Outcomes and prognostic factors in modern era management of major salivary gland cancer

“…A similar retrospective series with short follow-up included 12 high-risk patients receiving chemoradiation. They showed that the use of chemoradiation was associated with significantly better local control with no difference in overall survival compared to patients receiving RT alone[21]. Seven patients in our study received adjuvant chemoradiation.…”