Biological synthesis of silver nanoparticles using Rheum ribes and evaluation of their anticarcinogenic and antimicrobial potential: A novel approach in phytonanotechnology

Aygün, Ayşenur; Gülbağça, Fulya; Nas, Mehmet Salih; Alma, Mehmet Hakkı; Çalımlı, Mehmet Harbi; Ustaoglu, Buket; Altunoğlu, Yasemin Çelik; Baloğlu, Mehmet Cengiz; Cellat, Kemal; Şen, Fatih

doi:10.1016/j.jpba.2019.113012

Cited by 110 publications

(37 citation statements)

References 61 publications

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“…11 Also, comparing with the traditional methods, green methods enable the fabrication of different shapes of NPs that are distinguished with unique features under mild pressure and temperature conditions. 9,11 Several green chemistry methods have been developed for the fabrication of NPs using plant extracts, 12 algae, 13 fungi, 14 and bacteria. 15 Cyanobacteria are excellent bio-systems for the intracellular or extracellular production of NPs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

117

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Background: The emergence of multi drug-resistant (MDR) bacterial infections and cancer has necessitated the development and discovery of alternative eco-safe antibacterial and anticancer agents. Biogenic fabrication of metallic nanoparticles is an emerging discipline for production of nanoproducts that exert potent anticancer and antibacterial activity, and do not suffer from the limitations inherent in physiochemical synthesis methods. Methodology: In this study, we isolated, purified, and characterized a novel cyanobacteria extract (Desertifilum IPPAS B-1220) to utilize in biofabrication of silver nanoparticles (D-SNPs). D-SNPs were produced by adding Desertifilum extract to silver nitrate solution under controlled conditions. Biofabrication of D-SNPs was confirmed using a UV-Vis spectrophotometer. The resultant D-SNPs were characterized using XRD, FTIR, SEM, and TEM. The toxicity of D-SNPs against five pathogenic bacteria and three cancer cell lines (MCF-7, HepG2, and Caco-2) was evaluated. Results: Formation of D-SNPs was indicated by a color change from pale yellow to dark brown. The peak of the surface plasmon resonance of the D-SNPs was at 421 nm. The XRD detected the crystallinity of D-SNPs. FTIR showed that polysaccharides and proteins may have contributed to the biofabrication of D-SNPs. Under SEM and TEM, the D-SNPs were spherical with diameter ranges from 4.5 to 26 nm. The D-SNPs significantly suppressed the growth of five pathogenic bacteria, and exerted cytotoxic effects against MCF-7, HepG2, and Caco-2 cancer cells with IC 50 values of 58, 32, and 90 µg/mL, respectively. Conclusion: These findings showed for the first time the potentiality of novel cyanobacteria strain Desertifilum IPPAS B-1220 to fabricate small SNPs that acted as potent anticancer and antibacterial material against different cancer cell lines and pathogenic bacterial strains. These findings encourage the researchers to focus on cyanobacteria in general and especially Desertifilum sp. IPPAS B-1220 for synthesizing different NPs that opening the window for new applications.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

117

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“…15,26,27 In addition, AgNPs are utilized in various subelds of medicine as plasmonic antennas, diagnostic agents, and as nanoprobes to target and image small molecules such as DNA, proteins, cell tissue, and tumors. [28][29][30] Because AgNPs exhibit a red-shi in the plasmonic extinction band in the near-infrared (NIR) optical window region (700-900 nm), they are also used as imaging and photothermal agents to visualize and destroy cancer cells. 31,32 Their wide applicability and versatility have led to an increased demand for optimized AgNPs with tuned physical, optical, and chemical properties for various applications.…”

Section: Introductionmentioning

confidence: 99%

A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution

et al. 2020

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“…The expansion of resistance to various antimicrobial drugs available, as well as to newly developed antibiotics, and the corresponding increase in infections acquired both in hospitals and in the community, makes the development of alternative treatments imperative. Silver has been reintroduced into the field of biomedicine as a promising strategy to counter this worrying trend, and AgNPs have been found to be a less toxic alternative than the use of silver ions [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effect of silver nanorings

et al. 2020

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Background: The emergence and expansion of antibiotic resistance makes it necessary to have alternative antiinfective agents, among which silver nanoparticles (AgNPs) display especially interesting properties. AgNPs carry out their antibacterial action through various molecular mechanisms, and the magnitude of the observed effect is dependent on multiple, not fully understood, aspects, particle shape being one of the most important. In this article, we conduct a study of the antibacterial effect of a recently described type of AgNP: silver nanorings (AgNRs), making comparisons with other alternative types of AgNP synthesized in parallel using the same methodology. Results: When they act on planktonic forms, AgNRs produce a smaller effect on the viability of different bacteria than nanoparticles with other structures although their effect on growth is more intense over a longer period. When their action on biofilms is analyzed, AgNRs show a greater concentration-dependent effect. In both cases it was observed that the effect on inhibition depends on the microbial species, but not its Gram positive or negative nature. Growth patterns in silver-resistant Salmonella strains suggest that AgNRs work through different mechanisms to other AgNPs. The antibacterial effect is also produced to some extent by the conditioning of culture media or water by contact with AgNPs but, at least over short periods of time, this is not due to the release of Ag ions. Conclusions: AgNRs constitute a new type of AgNP, whose antibacterial properties depend on their shape, and is capable of acting efficiently on both planktonic bacteria and biofilms.

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Biological synthesis of silver nanoparticles using Rheum ribes and evaluation of their anticarcinogenic and antimicrobial potential: A novel approach in phytonanotechnology

Cited by 110 publications

References 61 publications

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution

Antibacterial effect of silver nanorings

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