A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution

Miesen, Thomas J.; Engstrom, Arek M.; Frost, Dane C.; Ajjarapu, Ramya; Ajjarapu, Rohan; Lira, Citlali Nieves; Mackiewicz, Marilyn R.

doi:10.1039/d0ra01727b

Cited by 30 publications

(51 citation statements)

References 124 publications

(139 reference statements)

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“…The synthesis of hybrid lipid-coated AgNPs was modified from a similar procedure [71]. Briefly, in a 100 mL Erlenmeyer flask, 50 mL of each type of citrate-capped AgNPs (as received from nanoComposix.com) was allowed to stir at 400 rpm using a magnetic stir bar.…”

Section: Preparation Of Hybrid Lipid Shielded Silver Nanoparticles (Ag-soa-pc-1ht)mentioning

confidence: 99%

“…Using a well-established procedure developed by Miesen et al to anchor membranes to AgNPs surfaces [71], a series of commercially available spherical AgNPs with diameters ranging from 20-100 nm (Nanocomposix, San Diego, CA, USA) were coated with hybrid lipid membranes comprised of a mixture of SOA, PC, and HT to yield Ag-SOA-PC-HT stabilized nanoparticles [71][72][73]88,89]. The amounts of SOA, PC, and HT used to coat the varying size of AgNPs (20-100 nm) were adjusted based on the diameter of each nanoparticle type.…”

Section: Preparation Of Hybrid Lipid-coated Agnps Of Varying Sizesmentioning

confidence: 99%

“…The amounts of SOA, PC, and HT used to coat the varying size of AgNPs (20-100 nm) were adjusted based on the diameter of each nanoparticle type. The combination of these surface ligands creates a complex hybrid lipid-membrane architecture that unequivocally protects AgNP from surface oxidation and Ag + ion release in the presence of strong oxidants such as KCN even in the presence of membrane disrupting surfactants [71,72]. After encapsulating and anchoring the membrane with HT, Tween ® 20 was added to the AgNP solution to disrupt "nanoparticle-free liposomes" followed by purification by ultracentrifugation with a PES membrane with MWCO of 10 kD with nanopure water.…”

Section: Preparation Of Hybrid Lipid-coated Agnps Of Varying Sizesmentioning

confidence: 99%

“…Currently, the most robust options for enhancing the long-term stability of AgNPs is by surface functionalization with covalent ligands such as polyvinylpyrrolidone (PVP) [45], lipids [62], and polyethylene glycol (PEG) [63][64][65][66], thiolated PEG [67], or coating with inert inorganic substrates such as gold [63], iron [68], or silica [69,70]. More recently, Miesen et al showed that the use of hybrid lipid-membranes can significantly enhance the stability of spherical and triangular plate AgNPs by creating a tight packing arrangement around the Ag core, shielding the surface from oxidation and Ag + ion release in a range of strongly oxidizing conditions [71]. Engstrom et al later demonstrated that when Ag + ion dissolution is controlled, the hybrid lipid-coated AgNPs are more biocompatible than those coated with citrate ligands or lipid membranes that were able to undergo surface oxidation and Ag + ion release [72].…”

Section: Introductionmentioning

confidence: 99%

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Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

et al. 2021

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Silver nanoparticles (AgNPs) are widely used in commerce, however, the effect of their physicochemical properties on toxicity remains debatable because of the confounding presence of Ag+ ions. Thus, we designed a series of AgNPs that are stable to surface oxidation and Ag+ ion release. AgNPs were coated with a hybrid lipid membrane comprised of L-phosphatidylcholine (PC), sodium oleate (SOA), and a stoichiometric amount of hexanethiol (HT) to produce oxidant-resistant AgNPs, Ag–SOA–PC–HT. The stability of 7-month aged, 20–100 nm Ag–SOA–PC–HT NPs were assessed using UV–Vis, dynamic light scattering (DLS), and inductively coupled plasma mass spectrometry (ICP-MS), while the toxicity of the nanomaterials was assessed using a well-established, 5-day embryonic zebrafish assay at concentrations ranging from 0–12 mg/L. There was no change in the size of the AgNPs from freshly made samples or 7-month aged samples and minimal Ag+ ion release (<0.2%) in fishwater (FW) up to seven days. Toxicity studies revealed AgNP size- and concentration-dependent effects. Increased mortality and sublethal morphological abnormalities were observed at higher concentrations with smaller nanoparticle sizes. This study, for the first time, determined the effect of AgNP size on toxicity in the absence of Ag+ ions as a confounding variable.

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Section: Preparation Of Hybrid Lipid Shielded Silver Nanoparticles (Ag-soa-pc-1ht)mentioning

confidence: 99%

Section: Preparation Of Hybrid Lipid-coated Agnps Of Varying Sizesmentioning

confidence: 99%

Section: Preparation Of Hybrid Lipid-coated Agnps Of Varying Sizesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

et al. 2021

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“…To concern about the oxidation of silver, it is essential to mention that silver oxidation can be easily prevented by preparing appropriate surfactants such as graphene 49 and lipid membrane 50 or setting the nano-antenna in the inert environment such as Argon (Ar) and Helium (He) gases 51 . As the whole proposed nano-antenna is coated by the monolayer graphene, a chemical mechanism happens at the interface of graphene and silver, which is suitable to the reduction of silver oxidation 49 .…”

Section: Advantages and Fabrication Feasibility Of Smart Multibeam Crmentioning

confidence: 99%

Smart optical cross dipole nanoantenna with multibeam pattern

Moshiri

Nozhat

2021

Sci Rep

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In this paper, an optical smart multibeam cross dipole nano-antenna has been proposed by combining the absorption characteristic of graphene and applying different arrangements of directors. By introducing a cross dipole nano-antenna with two V-shaped coupled elements, the maximum directivity of 8.79 dBi has been obtained for unidirectional radiation pattern. Also, by applying various arrangements of circular sectors as director, different types of radiation pattern such as bi- and quad-directional have been attained with directivities of 8.63 and 8.42 dBi, respectively, at the wavelength of 1550 nm. The maximum absorption power of graphene can be tuned by choosing an appropriate chemical potential. Therefore, the radiation beam of the proposed multibeam cross dipole nano-antenna has been controlled dynamically by applying a monolayer graphene. By choosing a suitable chemical potential of graphene for each arm of the suggested cross dipole nano-antenna without the director, the unidirectional radiation pattern shifts ± 13° at the wavelength of 1550 nm. Also, for the multibeam nano-antenna with different arrangements of directors, the bi- and quad-directional radiation patterns have been smartly modified to uni- and bi-directional ones with the directivities of 10.1 and 9.54 dBi, respectively. It is because of the graphene performance as an absorptive or transparent element for different chemical potentials. This feature helps us to create a multipath wireless link with the capability to control the accessibility of each receiver.

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Lipid Nanoparticles for Drug Delivery

Wang

Liu

et al. 2021

Advanced NanoBiomed Research

196

110

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Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated enormous potential in delivering nucleic acid drugs as evidenced by the approval of two RNA therapies and mRNA COVID‐19 vaccines. In this review, an overview on different classes of lipid nanoparticles, including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, is first provided, followed by the introduction of their preparation methods. Then the characterizations of lipid nanoparticles are briefly reviewed and their applications in encapsulating and delivering hydrophobic drugs, hydrophilic drugs, and RNAs are highlighted. Finally, various applications of lipid nanoparticles for overcoming different delivery challenges, including crossing the blood–brain barrier, targeted delivery, and various routes of administration, are summarized. Lipid nanoparticles as drug delivery systems offer many attractive benefits such as great biocompatibility, ease of preparation, feasibility of scale‐up, nontoxicity, and targeted delivery, while current challenges in drug delivery warrant future studies about structure–function correlations, large‐scale production, and targeted delivery to realize the full potential of lipid nanoparticles for wider clinical and pharmaceutical applications in future.

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A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution

Abstract: Hybrid lipid membranes shields and protects silver nanoparticles (AgNPs) from surface oxidation, Ag+ ion release, aging, and shape conversion.

Cited by 30 publications

References 124 publications

Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

Silver Nanoparticles Stable to Oxidation and Silver Ion Release Show Size-Dependent Toxicity In Vivo

Smart optical cross dipole nanoantenna with multibeam pattern

Lipid Nanoparticles for Drug Delivery

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