Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods

Žárská, Monika; Šrámek, Michal; Novotný, Filip; Havel, Filip; Bábelová, Andrea; Mrázková, Blanka; Benada, Oldřich; Reiniš, Milan; Stĕpánek, I; Musílek, Kamil; Bártek, Jiří; Ursı́nyová, Monika; Novák, Ondřej; Dzijak, Rastislav; Kuča, Kamil; Proška, Jan; Hodný, Zdeněk

doi:10.1016/j.biomaterials.2017.10.044

Cited by 23 publications

(16 citation statements)

References 95 publications

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“…Therefore, such cytotoxic and genotoxic impacts of Au NRs could be effectively used in the photothermal treatment of lung cancer (Choi et al, 2013). Another recent study published by Zarska et al (2018) has examined possible hazardous effects of NMs by exposing gold nanorods modified with (16‐mercaptohexadecyl)trimethylammonium bromide to mice in assays conducted through in vitro and in vivo settings. Rajeshwari, Roy, Chandrasekaran, and Mukherjee (2016) has studied cytotoxic effects of Au NRs on A. cepa .…”

Section: Non‐magnetic Metallic Nanomaterialsmentioning

confidence: 99%

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Demir

2020

J of Applied Toxicology

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Nanomaterials (NMs) generally display fascinating physical and chemical properties that are not always present in bulk materials; therefore, any modification to their size, shape, or coating tends to cause significant changes in their chemical/physical and biological characteristics. The dramatic increase in efforts to use NMs renders the risk assessment of their toxicity highly crucial due to the possible health perils of this relatively uncharted territory. The different sizes and shapes of the nanoparticles are known to have an impact on organisms and an important place in clinical applications. The shape of nanoparticles, namely, whether they are rods, wires, or spheres, is a particularly critical parameter to affect cell uptake and site-specific drug delivery, representing a significant factor in determining the potency and magnitude of the effect. This review, therefore, intends to offer a picture of research into the toxicity of different shapes (nanorods, nanowires, and nanospheres) of NMs to in vitro and in vivo models, presenting an in-depth analysis of health risks associated with exposure to such nanostructures and benefits achieved by using certain model organisms in genotoxicity testing. Nanotoxicity experiments use various models and tests, such as cell cultures, cores, shells, and coating materials. This review article also attempts to raise awareness about practical applications of NMs in different shapes in biology, to evaluate their potential genotoxicity, and to suggest approaches to explain underlying mechanisms of their toxicity and genotoxicity depending on nanoparticle shape.

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Section: Non‐magnetic Metallic Nanomaterialsmentioning

confidence: 99%

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Demir

2020

J of Applied Toxicology

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“…Rod‐shaped GNPs can be synthetized with high yield, uniform size distribution, and tunability of the LSPR to the near infrared region, where biological tissues show lower absorption and the laser light can penetrate through the tissues . In contrast with cetyltrimethylammonium bromide (CTAB) stabilized gold nanorods (GNRs) exhibiting high cytotoxicity in vitro , the combination of GNRs (54 × 26 nm) with covalently bonded QAS, (16‐mercaptohexadecyl)trimethylammonium bromide (MTAB), does not affect the cellular homeostasis and does not cause the acute toxicity in mice . However, it is thought that during induction of photothermal effect the fs‐laser pulses can trigger fragmentation and reshaping of GNRs liberating the surface compound.…”

Section: Introductionmentioning

confidence: 99%

“…The thiol modification enables covalent anchorage of the compound to the surface of GNRs through gold‐sulfur bond . Using MTAB GNRs as a prototype of alkyl‐QAS stabilized nanoparticles displaying high cellular uptake and low toxicity , we analyzed physico‐chemical and biological properties of newly prepared POSAB GNRs.…”

Section: Introductionmentioning

confidence: 99%

Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity

Salajkova

Šrámek

Maliňák

et al. 2019

Journal of Biophotonics

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The photothermal cancer therapy using cationic gold nanorods (GNRs) stabilized by quaternary ammonium salts (QAS) have a great potential to enhance conventional cancer treatment as it promises the effective eradication of cancer cells including cells resistant to radio‐ and chemo‐therapy and the stimulation of anti‐tumor immune response. However, as the cytotoxicity of the conventional alkanethiol‐QAS compounds limits their utility in medicine, here we developed GNRs modified by novel highly hydrophilic cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain N,N,N‐trimethyl‐3,6,9,12,15‐pentaoxaheptadecyl‐17‐sulfanyl‐1‐ammonium bromide (POSAB) showing insignificant cytotoxicity in the free state. Surface modification of GNRs by POSAB allowed to prepare nanoparticles with good stability in water, high cellular uptake and localization in lysosomes that are a promising alternative to alkanethiol‐stabilized GNRs especially for biomedical applications.

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“…These results together indicate that AuNPs could either block or induce autophagy in a context‐dependent manner. In contrast with these results, Zarska et al demonstrated that gold nanorods were unable to induce intracellular activation of autophagy or to trigger lysosomal stress even after long‐term retention inside the cancer cells ( Figure ) . Given the high complexity of autophagy, it is important to recognize that reliable methods should be used to discriminate between enhanced autophagy (enhanced cargo degradation) and inhibition of autophagosomal‐lysosomal fusion (increased autophagosome accumulation but decreased cargo degradation) …”

Section: Leveraging Nanocarrier‐mediated Autophagy For Cancer Therapymentioning

confidence: 95%

Exploiting Nanomaterial‐Mediated Autophagy for Cancer Therapy

et al. 2018

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Autophagy is a conserved process that is critical for sequestering and degrading proteins, damaged or aged organelles, and for maintaining cellular homeostasis under stress conditions. Despite its dichotomous role in health and diseases, autophagy usually promotes growth and progression of advanced cancers. In this context, clinical trials using chloroquine and hydroxychloroquine as autophagy inhibitors have suggested that autophagy inhibition is a promising approach for treating advanced malignancies and/or overcoming drug resistance of small molecule therapeutics (i.e., chemotherapy and molecularly targeted therapy). Efficient delivery of autophagy inhibitors may further enhance the therapeutic effect, reduce systemic toxicity, and prevent drug resistance. As such, nanocarrier‐based drug delivery systems have several distinct advantages over free autophagy inhibitors that include increased circulation of the drugs, reduced off‐target systemic toxicity, increased drug delivery efficiency, and increased solubility and stability of the encapsulated drugs. With their versatile drug encapsulation and surface‐functionalization capabilities, nanocarriers can be engineered to deliver autophagy inhibitors to tumor sites in a context‐specific and/or tissue‐specific manner. This review focuses on the role of nanomaterials utilizing autophagy inhibitors for cancer therapy, with a focus on their applications in different cancer types.

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Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods

Cited by 23 publications

References 95 publications

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity

Exploiting Nanomaterial‐Mediated Autophagy for Cancer Therapy

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