Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore

Abstract

Translin, and its binding partner protein TRAX (translin-associated factor-X) are a paralogous pair of conserved proteins, which have been implicated in a broad spectrum of biological activities, including cell growth regulation, mRNA processing, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis, although their precise role in some of these processes remains unclear. Furthermore, translin (with or without TRAX) has nucleic-acid-binding activity and it is apparent that controlling nucleic acid metabolism and distribution are central to the biological role(s) of this protein and its partner TRAX. More recently, translin and TRAX have together been identified as enhancer components of an RNAi (RNA interference) pathway in at least one organism and this might provide critical insight into the biological roles of this enigmatic partnership. In the present review we discuss the biological and the biochemical properties of these proteins that indicate that they play a central and important role in eukaryotic cell biology.

Sex-biased genetic effects on gene regulation in humans

“…in spermatogenesis, neuronal regulation, and genome stability (Jaendling and McFarlane 2010). ODF2L (YRI) ( Fig.…”

Hydrolysis Rates of Different Small Interfering RNAs (siRNAs) by the RNA Silencing Promoter Complex, C3PO, Determines Their Regulation by Phospholipase Cβ

“…10,11). Together with its partner translin, an RNA-binding protein, TRAX has been implicated in chromosomal translocations, spermatogenesis, and dendritic RNA trafficking.…”

Les remaniements chromosomiques complexes

“…On note aussi la présence de séquences capables de créer des structures secondaires particulières, telles que les séquences palindromiques, voire des séquences pouvant induire des modifications de la conformation de la double hélice, comme les séquences polypurines ou polypyrimidines [27]. Enfin, certaines séquences détectées correspondent à des sites de fixation de protéines particulières, comme les translines, retrouvées à proximité des points de cassure de nombreuses translocations, sans que leur rôle exact dans la cassure ou la réparation de la molécule d'ADN aient été éluci-dés [28]. Beaucoup de ces éléments sont des facteurs d'instabilité génomique susceptibles de perturber la machinerie réplicative, d'exacerber la survenue de cassures double-brin ou de biaiser les mécanismes de réparation.…”