Biological role of lutein in the light-induced retinal degeneration

Sasaki, Mariko; Yuki, Kenya; Kurihara, Toshihide; Miyake, Seiji; Noda, K; Kobayashi, Saori; Ishida, Susumu; Ozawa, Yoko

doi:10.1016/j.jnutbio.2011.01.006

Cited by 89 publications

(95 citation statements)

References 28 publications

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“…Pamplona (2003) indica que el contenido de vitaminas A, C y E del fruto de durazno le confieren un efecto antioxidante de gran importancia para la conservación y funcionamiento de las arterias coronarias, por lo cual su consumo beneficia el sistema cardiaco en general. La luteína y zeaxantina presentes en este fruto cumplen un papel importante en la visión, como reportan Sasaki et al (2012), en donde la luteína actúa contra el estrés oxidativo generado por la luz en la retina. Otros beneficios que se obtienen mediante el consumo del durazno, es el aportado por el sorbitol que contribuye a la salud dental; y por la sacarosa y fructosa sobre la salud gastrointestinal (Font et al, 2013).…”

Section: Actividad Antioxidanteunclassified

Fisiología y bioquímica de la maduración del fruto de durazno [<i>Prunus persica</i> (L.) Batsch]. Una Revisión

Africano

Almanza-Merchán

Balaguera-López

2015

Rev. Colomb. Cienc. Hortic.

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RESUMENEl durazno pertenece a la familia Rosaceae; es una drupa muy apetecida por su agradable sabor y cualidades nutricionales, al igual que en la industria de alimentos. Es un fruto climatérico, altamente perecedero con altas tasas respiratorias y de producción de etileno. Durante la maduración presenta pérdida del color verde de la epidermis y adquiere tonalidades rojizas/amarillas, por degradación de clorofilas y biosíntesis de antocianinas y carotenoides; también presenta aumento en el contenido de azúcares solubles, emisión de compuestos voláti-les y actividad antioxidante, disminución en el contenido de ácidos orgánicos, firmeza y almidón. Debido a las características fisiológicas y bioquímicas propias del fruto relacionadas con la alta perecibilidad, se dificultan las labores de manipulación, transporte y comercialización, por lo anterior se realizó la actualización de la fisiología y bioquímica de la maduración del fruto de durazno.

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Section: Actividad Antioxidanteunclassified

Fisiología y bioquímica de la maduración del fruto de durazno [<i>Prunus persica</i> (L.) Batsch]. Una Revisión

Africano

Almanza-Merchán

Balaguera-López

2015

Rev. Colomb. Cienc. Hortic.

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“…8,14 Briefly, the mice were rested for several days and used at the age of 6 to 7 weeks. Before light exposure, the mice were dark-adapted by keeping them in complete darkness for 12 hours.…”

Section: Light Exposurementioning

confidence: 99%

“…[3][4][5] It is well accepted that the effects of oxidative stress on the retinal pigment epithelium (RPE) contribute to AMD's pathogenesis, [3][4][5][6] and light exposure can be involved as a risk of AMD. 3,5,7 Light exposure is known to cause oxidative stress in the neural retina [7][8][9] ; however, the influences of light stimuli on the RPE are not fully understood.…”

mentioning

confidence: 99%

“…The process of light-toneural signal transformation is closely associated with the visual cycle, in which interactions between photoreceptor cells and RPE cells cause the sequential isomerization of retinoid molecules to regenerate rhodopsin. When the light stimulus is very high, both the toxicity of the products from visual cycle and excessive metabolic action in the cells can cause oxidative stress-induced apoptosis in the photoreceptors, [7][8][9] and this apoptosis can be prevented by administering antioxidants, such as lutein. 8,10 Given that the RPE cells perform metabolic functions related to the visual cycle, oxidative stress accumulating in the RPE after light exposure could induce the pathological changes in the RPE that are associated with AMD.…”

mentioning

confidence: 99%

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Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice

Narimatsu

Ozawa

Miyake

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To elucidate the influences of light exposure on the retinal pigment epithelium (RPE) in vivo that may be involved in the pathogenesis of AMD.METHODS. Six-to 7-week-old BALB/c mice were exposed to light at 2000 lux for 3 hours. Flatmount RPE samples were immunostained with anti-ZO-1 antibody for evaluating tight junction, anti-N-cadherin, and anti-b-catenin antibodies for adherens junction, and stained with phalloidin for actin cytoskeleton. The reactive oxygen species (ROS) level was measured using DCFH-DA; Rho-associated coiled-coil forming kinase (ROCK) activity was by ELISA. RESULTS. Light exposure disrupted staining patterns of tight junctions, adherens junctions, and actin cytoskeleton in the RPE, where ROS was elevated. However, NAC treatment avoided the RPE changes, reducing ROS. ROCK activity increased after light exposure was suppressed by NAC, and the structural disruptions were suppressed by Y-27632. The levels of MCP-1, CCL11, and IL-6 increased after light exposure were suppressed by NAC. Light-induced MCP-1 and IL-6 were suppressed by Y-27632. Macrophage recruitment after light exposure was also suppressed either by NAC or Y-27632.CONCLUSIONS. Light exposure induced ROS and Rho/ROCK activation, which caused disruption of cell-cell junctions (tight junctions and adherens junctions) and actin cytoskeleton, the RPE's barrier structure, and induced AMD-associated pathological changes in the RPE-choroid.

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“…DNA, proteins and lipids) in the human eye from oxidative damage in vivo. Sasaki et al (2011) investigated in mice, after light exposure, the effect of lutein intake on visual function assessed with electroretinograms, thickness of outer nuclear layer of the enucleated eyes, photoreceptor cell apoptosis and light-induced DNA damage. Two groups of mice received a standard chow and another group received for 10 days the same chow supplemented with 0.1 % lutein, providing a daily lutein intake estimated to be 170 mg/kg body weight, which is about 500 times the maximum dose used in human interventions.…”

Section: Scientific Substantiation Of the Claimed Effect (Id 1603 1604)mentioning

confidence: 99%

Scientific Opinion on the substantiation of health claims related to lutein and maintenance of normal vision (ID 1603, 1604, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Products¹

2012

EFS2

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) in the framework of further assessment related to lutein and maintenance of normal vision. The food constituent that is the subject of the claim, lutein, is sufficiently characterised. The claimed effect, maintenance of normal vision, is a beneficial physiological effect. The proposed target population is the general population. In weighing the evidence, the Panel took into account that one human intervention study in healthy subjects did not show an effect of lutein on visual acuity or glare sensitivity, that the results of this study were inconsistent as regards contrast sensitivity, and that the evidence provided for a mechanism by which lutein could exert the claimed effect in vivo in humans is weak. On the basis of the data presented, the Panel concludes that the evidence provided is insufficient to establish a cause and effect relationship between the consumption of lutein and maintenance of normal vision. . The Commission has agreed with EU Member States that a certain number of Article 13 health claims would be eligible for further assessment by EFSA in order to be able to take a final decision on whether or not to include these claims in the list of permitted health claims. This opinion addresses the scientific substantiation of a health claim in relation to lutein and maintenance of normal vision. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims, references that EFSA has received from Member States or directly from stakeholders and the additional information provided by the competent Authority of Austria for further assessment of this claim.The food constituent that is the subject of the health claim is lutein. The Panel considers that lutein is sufficiently characterised.The claimed effect, which is eligible for further assessment, is maintenance of normal vision. The proposed target population is the general population. Visual function, including visual acuity and contrast sensitivity, can be assessed by established methods. The Panel considers that maintenance of normal vision is a beneficial physiological effect.The NDA Panel has already issued two opinions in relation to a claim on lutein and maintenance of normal vision, in which over 200 references which were considered. In the framework of further assessment three human intervention studies, of which only two were on healthy subjects, one human observational study and one case report, as well as a number of animal, in vitro and ex vivo studies were provided. This evaluation is based on the scientific references provided in the present and in the previous submissions which addressed the effects of lutein on maintenance of vision and/or on the mechanisms by which lutein could exert the claimed effect in the target population.Two publ...

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Biological role of lutein in the light-induced retinal degeneration

Cited by 89 publications

References 28 publications

Fisiología y bioquímica de la maduración del fruto de durazno [<i>Prunus persica</i> (L.) Batsch]. Una Revisión

Fisiología y bioquímica de la maduración del fruto de durazno [<i>Prunus persica</i> (L.) Batsch]. Una Revisión

Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice

Scientific Opinion on the substantiation of health claims related to lutein and maintenance of normal vision (ID 1603, 1604, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

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