Biological role of heparan sulfate in osteogenesis: A review

Xu, Zhujie; Chen, Shayang; Feng, Dong; Yi, Lunzhao; Wang, Qiqi; Gao, Tianshu; Liu, Zhenwei; Zhang, Yan; Chen, Jinghua; Qiu, Lipeng

doi:10.1016/j.carbpol.2021.118490

Cited by 9 publications

(3 citation statements)

References 165 publications

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“…To be specific, heparan sulfate stimulates osteoblast proliferation and differentiation, regulates MSC differentiation, and stimulates bone marrow MSCs. Heparanase is considered to play a significant role in ECM remodeling by coordinating several osteogenesis‐related signaling pathways (Karamanos et al, 2021; Xu et al, 2021). González‐Alva et al (2010) showed that HPSE protein promotes tumor growth and osteoclast activity in AB and that it is overexpressed in AB bone tissue and near the invasive front of the tumor nest.…”

Section: Discussionmentioning

confidence: 99%

Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Zhang,

Wang,

Qian

et al. 2023

Oral Diseases

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ObjectiveTo investigate the effects of key pathogenic genes involved in the development of jaw ameloblastoma (AB) and its associated extracellular matrix (ECM) on osteogenic differentiation in order to provide a theoretical foundation for future research into bone aggressiveness of AB.MethodsThe essential genes were identified by five AB patients for whole‐exome sequencing and the microarray datasets GES38494 and GES132472. Moreover, the expression of key genes and their encoded proteins in AB tissues was explored. In addition, AB‐derived the decellularized ECM (ABdECM) tissues were generated by the decellularization technique. Furthermore, the osteogenic development of periodontal ligament stem cells (PDLSCs) was mimicked by simulating the effects of the AB tumor microenvironment (TME).ResultsThe AB essential genes including COL1A2, COL4A2, FBN1, and HPSE were discovered. Among them, the expression of HPSE was down‐regulated, while that of COL1A2, COL4A2, and FBN1 was noticeably upregulated in AB compared with normal gingival tissues of the jaws. In vitro osteogenic differentiation of PDLSCs was suppressed by the ABdECM.ConclusionsAbnormal ECM proteins encoded by COL4A2, COL1A2, FBN1, and HPSE genes can cause disturbance in the ECM environment of AB and promote bone resorption.

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Section: Discussionmentioning

confidence: 99%

Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Zhang,

Wang,

Qian

et al. 2023

Oral Diseases

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“…HS is involved in osteogenesis via coordinating multiple signaling pathways. The potential effect of HS on osteogenesis is a complicated and delicate biological process, which involves the participation of osteocytes, chondrocytes, osteoblasts, osteoclasts and a variety of cytokines [ 197 , 198 , 199 , 200 , 201 , 202 ].…”

Section: Heparin and Pps In Bone Healthmentioning

confidence: 99%

Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues

Smith

Melrose

2023

Pharmaceuticals

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Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like molecule, shares many of the interactive properties of HS. The aim of this review was to outline the potential of PPS as an interventional therapeutic protective agent in physiological processes affecting pathological tissues. PPS is a multifunctional molecule with diverse therapeutic actions against many disease processes. PPS has been used for decades in the treatment of interstitial cystitis and painful bowel disease, it has tissue-protective properties as a protease inhibitor in cartilage, tendon and IVD, and it has been used as a cell-directive component in bioscaffolds in tissue engineering applications. PPS regulates complement activation, coagulation, fibrinolysis and thrombocytopenia, and it promotes the synthesis of hyaluronan. Nerve growth factor production in osteocytes is inhibited by PPS, reducing bone pain in osteoarthritis and rheumatoid arthritis (OA/RA). PPS also removes fatty compounds from lipid-engorged subchondral blood vessels in OA/RA cartilage, reducing joint pain. PPS regulates cytokine and inflammatory mediator production and is also an anti-tumor agent that promotes the proliferation and differentiation of mesenchymal stem cells and the development of progenitor cell lineages that have proven to be useful in strategies designed to effect repair of the degenerate intervertebral disc (IVD) and OA cartilage. PPS stimulates proteoglycan synthesis by chondrocytes in the presence or absence of interleukin (IL)-1, and stimulates hyaluronan production by synoviocytes. PPS is thus a multifunctional tissue-protective molecule of potential therapeutic application for a diverse range of disease processes.

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“…It is beyond the scope of this review to cover the complexities of the fine structure of HS other than to point out the extremely large number of ligands that can interact with HS, which is evident in the entries listed in Table 4. Many excellent reviews have appeared on HS, and the interested reader is directed to these for further information on the diverse roles of HS in various cell and tissue contexts [20,261,[325][326][327][328][329][330][331][332][333][334][335][336]. Tenascin ECM glycoprotein, stabilizes perineuronal net formation in the CNS [385,386] TSP-1, 2…”

Section: Syndecanmentioning

confidence: 99%

The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour

Farrugia,

Melrose

2023

IJMS

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This review examines the roles of HS–proteoglycans (HS–PGs) in general, and, in particular, perlecan and syndecan as representative examples and their interactive ligands, which regulate physiological processes and cellular behavior in health and disease. HS–PGs are essential for the functional properties of tissues both in development and in the extracellular matrix (ECM) remodeling that occurs in response to trauma or disease. HS–PGs interact with a biodiverse range of chemokines, chemokine receptors, protease inhibitors, and growth factors in immune regulation, inflammation, ECM stabilization, and tissue protection. Some cell regulatory proteoglycan receptors are dually modified hybrid HS/CS proteoglycans (betaglycan, CD47). Neurexins provide synaptic stabilization, plasticity, and specificity of interaction, promoting neurotransduction, neurogenesis, and differentiation. Ternary complexes of glypican-1 and Robbo–Slit neuroregulatory proteins direct axonogenesis and neural network formation. Specific neurexin–neuroligin complexes stabilize synaptic interactions and neural activity. Disruption in these interactions leads to neurological deficits in disorders of functional cognitive decline. Interactions with HS–PGs also promote or inhibit tumor development. Thus, HS–PGs have complex and diverse regulatory roles in the physiological processes that regulate cellular behavior and the functional properties of normal and pathological tissues. Specialized HS–PGs, such as the neurexins, pikachurin, and Eyes-shut, provide synaptic stabilization and specificity of neural transduction and also stabilize the axenome primary cilium of phototoreceptors and ribbon synapse interactions with bipolar neurons of retinal neural networks, which are essential in ocular vision. Pikachurin and Eyes–Shut interactions with an α-dystroglycan stabilize the photoreceptor synapse. Novel regulatory roles for HS–PGs controlling cell behavior and tissue function are expected to continue to be uncovered in this fascinating class of proteoglycan.

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Biological role of heparan sulfate in osteogenesis: A review

Cited by 9 publications

References 165 publications

Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Extracellular matrix of ameloblastoma‐derived negatively regulates osteogenic differentiation

Pentosan Polysulfate Affords Pleotropic Protection to Multiple Cells and Tissues

The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour

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