Biological Responses to Asbestos Inhalation and Pathogenesis of Asbestos-Related Benign and Malignant Disease

Solbes, Eduardo; Harper, Richart W

doi:10.1136/jim-2017-000628

Cited by 44 publications

(32 citation statements)

References 50 publications

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“…These include inflammation, apoptosis, and oxidative stress. Shortly after contact with asbestos fibres, the first cells that come into contact with inhaled asbestos fibres (epithelial cells lining the airways and alveoli) are directly injured (Solbes and Harper, 2018). This injury has been shown to occur through both cytolytic and non-cytolytic mechanisms in humans.…”

Section: Pathogenesis Of Asbestosmentioning

confidence: 99%

“…PKC translocates to the cell membrane when activated and mediates numerous cellular functions, including regulation of gene expression, cellular growth, cellular shape, and epithelial permeability (Winter et al, 1990). Asbestos has also been shown to activate tyrosine kinases, which promote cell proliferation, growth factor signal transduction, and alterations in cell-cell adherence (Christe, 2009;Kramp, 2009;Solbes and Harper, 2018). The proposed mechanisms outlining the major responses initiated by asbestos fibres exposure in the lungs tissue are shown in Figure 1.…”

Section: Pathogenesis Of Asbestosmentioning

confidence: 99%

“…The proposed mechanisms outlining the major responses initiated by asbestos fibres exposure in the lungs tissue are shown in Figure 1. Similarly, asbestos exposure is associated with activation of oncogenes and loss of tumour suppressor genes (Solbes and Harper, 2018). Oncogenes play a central role in cell proliferation and cell transformation.…”

Section: Pathogenesis Of Asbestosmentioning

confidence: 99%

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Asbestos: A Silent Potent Killer

Zephaniah

Aremu

2019

EUROPEAN J ENV PUBLI

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Asbestos is a general name given to a group of carcinogenic and genotoxic fibrous silicate minerals that have been of commercial values over the years. They include chrysolite, amosite, crocidolite, tremolite, actinolite and anthrophylite. Because of their special properties such as flexibility, tensile length, heat stability and resistivity to chemical, electrical, thermal and biological attacks, asbestos fibres have been used as components of several construction, building and automotive materials. This materials when disturbed, during home redecoration, demolition, renovation and automobiles repairs, release asbestos fibres into the atmosphere leading to both residential and occupational exposure. Measured concentration of fibres has been found to be higher in urban areas (especially those in close proximity with asbestos industries which may include mining and demolition sites) than in rural areas. Several studies have linked asbestos exposure to several serious health challenges such as lung cancer, mesothelioma, asbestosis, and other respiratory diseases. Although the main mechanisms through which asbestos can lead to diseases are not fully understood, three hypotheses have been made. These include alterations at the chromosomal level, activation of oncogenes, loss of tumour suppressor genes, alterations in cellular signal transduction pathways, generation of reactive oxygen and nitrogen species, and direct mechanical damage to cells from asbestos fibres. This article reviews briefly the ways by which the general public (occupational and nonoccupational) can be exposed to asbestos and its most recent pathogenic mechanisms leading to malignant and non-malignant disease conditions.

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Section: Pathogenesis Of Asbestosmentioning

confidence: 99%

Section: Pathogenesis Of Asbestosmentioning

confidence: 99%

Section: Pathogenesis Of Asbestosmentioning

confidence: 99%

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Asbestos: A Silent Potent Killer

Zephaniah

Aremu

2019

EUROPEAN J ENV PUBLI

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“…Although the asbestos production and usage have been banned in many countries, the asbestos-related diseases still represent an enormous public health problem all over the world [1][2][3]. Occupational and environmental exposure to asbestos fibres has been associated with the development of asbestosis, pleural diseases such as pleural plaques, diffuse pleural thickening, pleural effusion, malignant mesothelioma (MM) of the pleura, peritoneum and other serosal surfaces, lung cancer, and some other types of malignant diseases, including cancer of the larynx, cancer of the ovary, and possibly also cancers of the buccal mucosa, the pharynx, the gastrointestinal tract, and the kidney [1][2][3][4][5][6][7][8][9][10]. The asbestos-related diseases are considered to be among the most investigated occupational diseases [1-3, 7, 8, 10].…”

Section: Introductionmentioning

confidence: 99%

Asbestos-Related Diseases and Blood Biomarkers

Franko¹,

Dolžan²,

Goričar³

et al. 2020

Asbestos-Related Diseases

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Asbestos-related diseases, including asbestosis, benign pleural diseases, lung cancer, other types of cancer, and especially malignant mesothelioma (MM), still represent an enormous problem all over the world and are among the most investigated occupational diseases. Considering that MM is a highly aggressive and severe malignant cancer of pleura, peritoneum and other serosal surfaces, new blood biomarkers for earlier diagnosis, following response to treatment and disease progression, have been intensively investigated. Several studies suggested that soluble mesothelin-related peptides, fibulin-3, survivin, osteopontin, vimentin, calretinin, and many others could be helpful in diagnosis, detecting the progression of MM and evaluating tumour response to treatment; however, these biomarkers have not been validated in clinical practice. Therefore, search for novel better stand-alone or composite biomarkers is under way. The aim of this chapter is to present the importance of blood biomarkers in evaluating the risk of developing asbestos-related diseases, early diagnosis, following the response to treatment and progression of these diseases, with special emphasis on MM.

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“…The crystalline structure of the rock can break down into very thin fibres that, if absorbed, are extremely pathogenic (Baumann et al, 2013;Carnevale, 2007;Inail, 2016Inail, , 2018. The disease's severity depends on the duration of the exposure, the intensity-that is, the quantity of toxic powder absorbed-and the individual's reaction (see Ak et al, 2015;Gilham et al, 2015;Oury et al, 2016;Solbes and Harper, 2018). There are different asbestos-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Solastalgia's mourning and the slowly evolving effect of asbestos pollution: A qualitative study in Italy

Testoni

Mauchigna

Marinoni

et al. 2019

Heliyon

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In Italy, the problem of asbestos pollution is increasing in severity. In fact, in recent years, the number of people affected by asbestos-related illnesses has been growing because of the fibre's slowly evolving effects and its progressive pollution in the environment adjacent to the places where it is processed. Even though the physical consequences of asbestos are now quite clear, few studies have examined the psychological consequences of this kind of disaster. Since it is difficult to perceive its pathogenicity in daily life, this study was conducted in the affected areas of northeastern Italy, using the qualitative research in psychology with 51 persons who experienced asbestos-related illnesses (19 sick persons and 37 relatives of sick persons). Their narratives described being rooted in a space contaminated by an invisible enemy. In particular, attention was paid to the consequent solastalgia, a kind of mourning arising from loss of place attachment. Results of the qualitative analysis revealed how the different phases of the Elisabeth Kubler-Ross DABDA (Denial Anger Bargaining Depression Acceptance) model of coping with death constitute such feelings, whereas the dual-process model of Stroebe and Schut emphasised how these people seem to be loss oriented because of their perceived lack of community restoration. A discussion of the relationships between attribution of responsibility, entirely external and mostly inscribed in the DABDA categories of ‛anger' and ‛acceptance', is presented, with further considerations about mourning and the need to improve specific psychological support in this field of environmental disaster.

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Biological Responses to Asbestos Inhalation and Pathogenesis of Asbestos-Related Benign and Malignant Disease

Cited by 44 publications

References 50 publications

Asbestos: A Silent Potent Killer

Asbestos: A Silent Potent Killer

Asbestos-Related Diseases and Blood Biomarkers

Solastalgia's mourning and the slowly evolving effect of asbestos pollution: A qualitative study in Italy

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