Biological properties of the chitosan-gelatin sponge wound dressing

Deng, Chunmei; Lan-zhen, HE; Zhao, Ming; Yang, Dan; Liu, Yi

doi:10.1016/j.carbpol.2007.01.014

Cited by 125 publications

(75 citation statements)

References 3 publications

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“…Chitosan-gelatin sponge wound dressing had demonstrated a superior antibacterial effect. Additionally, chitosan gelatin sponge allowed the wound site to contract markedly and shortened the wound healing time, as compared with sterile Vaseline gauze [74]. Widely used surface modification techniques include coating, oxidation by low temperature plasma for better printing and adhesion and surfactant addition for antistatic.…”

Section: Biocompatibilitymentioning

confidence: 99%

Is Chitosan a New Panacea? Areas of Application

Castro¹,

Paulín²

2012

The Complex World of Polysaccharides

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Chitin is a big molecule composed of -beta-1,4-N-acetylglucosamine (GlcNAc) monomers. There are three forms of chitin: , , and chitin. The -form, is mainly obtained from crab and shrimp. Both and chitin/chitosan are commercially available [5]. Sources of chitinIn the book "Chitin" published by Muzarelli in 1977, we can find a complete list of organisms that contain chitin: Fungi, Algae, Cnidaria (jellyfish), Aschelminthes (round worm), Entoprocta, Bryozoa (Moss or lace animals, Phoronida (Horseshoe worms), Brachiopoda(Lamp shells), Echiruda, Annelida (Segmented worms), Mollusca, Arthropoda and Ponogophora [6]). Herring, P.J in 1979 wrote that chitin is the main component of arthropod exoskeletons, tendons, and the linings of their respiratory, excretory, and digestive systems, as well as insects external structure and some fungi. It is also found in the reflective material (iridophores) of both epidermis and eyes of arthropods and cephalopods (phylum: Mollusca) and the epidermal cuticle of the vertebrate Paralipophrys trigloides (fish) is also chitinous [7,8]. The main commercial sources of chitin are the shell wastes of shrimp, lobsters, crabs and krill. There are three forms of chitin: , , and chitin. The -form, is composed of alternating antiparallel polysaccharide strands and is mainly obtained from crab and shrimp. -Chitin is by far the most abundant; it occurs in fungal and yeast cell walls, krill, lobster and crab tendons and shells, shrimp shells, and insect cuticle. The rarer -chitin is composed of parallel strands of polysaccharides, is found in association with proteins in squid pens [9,10] and in the tubes synthesized by pogonophoran and vestimetiferan worms [11,12]. It also occurs in aphrodite chaetae [13] as well as in the lorica, built by some seaweeds or protozoa [14,15,16]. And 2 parallel chains alternating with an antiparallel strand constitute gamma chitin and are found in fungi [15].

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Section: Biocompatibilitymentioning

confidence: 99%

Is Chitosan a New Panacea? Areas of Application

Castro¹,

Paulín²

2012

The Complex World of Polysaccharides

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“…The antimicrobial properties of PVP-CMC and PVP-CMC-BA hydrogels were investigated by agar diffusion method (30,31). Antimicrobial characteristics of these hydrogels were examined on the basis of the dimension of inhibition zone generated in the presence and absence of pathogenic bacteria like Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa and fungi like Candida albicans and Candida parapsi-losis.TYve antibacterial assay was conducted in a sterile nutrient agar (2%) medium that was inoculated with the aforementioned bacterial strains under aseptic condition.…”

Section: Assay Of Antimicrobial Propertymentioning

confidence: 99%

Development and Characterization of Novel Medicated Hydrogels for Wound Dressing

Roy¹,

Saha²,

Kitano³

et al. 2010

Soft Materials

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□ The medicated hydrogels were prepared aseptically under moist heat treatment using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerin and/or boric acid (BA) and designated as PVP-CMC and PVP-CMC-BA. The aim of this study was to develop some medicinal values-based hydrogels. BA was used to build up the medicinal values (antiseptic and antimicrobial properties) within the hydrogels. Optical images, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy of the hydrogels indicated that boric acid is uniformly dispersed within the cross-linked hydrogel network that may heal and protect the wounds from infections/sepsis. Swelling study in presence of water and physiological saline solution confirmed its reasonable absorption capacity. The rheological properties and mechanical properties demonstrated that the boric acid incorporated hydrogels are quite flexible. Assessment of antimicrobial property study proves that PVP-CMC-BA (3 % BA) has strong infection protection capacity.Keywords Boric acid, Hydrogels, Swelling, Viscoelastic properties, Wound dressing INTRODUCTIONThe medicated hydrogels are the hydrogels that possess some medicinal value within them. They are cross-linked polymeric gels that have water-holding and nonadhering properties. Hydrogels can be prepared with monomers, prepolymers, or existing hydrophilic polymers as starting materials. They are generally specified by two component systems. One of the components is hydrophilic, which has water insoluble three-dimensional polymer networks, and the second component is water. They may swell in water up to a large extent and reach the equilibrium state while retaining their original shape (1).In fact, a hydrogel is considered as a kind of cheap, effective, convenient material for wound dressing, due to its good biocompatibility, water absorption ability, moisture retention, and ventilating capacity (2). They are closely resembled to living tissue in their physical properties because of their relatively high water content as well as soft and rubbery consistency (3). Numerous research studies have established that a moist wound environment is most favorable for healing (4). Hydrogel wound burn dressings were first invented by Rosiak et al. in 1989, which have many interesting properties, such as immediate pain control, easy replacement, transparency, absorption, prevention of loss of body fluids, barrier against bacteria, good adhesion, easy handling, oxygen permeability, control of drug dosage, and so on (3,5,6).The hydrogel dressings are usually directly applied to the wounds, thus the biocompatibility and non-toxicity factors are required to be taken into consideration. Polyvinylpyrrolidone (PVP) is a well-known polymer with good biocompatibility; hence, this polymer can be used as one of the main components of pseudo hydrogel preparation for temporary skin covers or wound dressings (6, 7). PVP is used in production of medicines and serves as blood substitute and blood d...

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“…Additionally, a reduction on the influx of activated tissue macrophages, which in turn decreases angiogenesis, fibroplasia, and connective tissue deposition, was also attributed to chitosan. 30 These features may substantiate the hemostatic properties preventing bleeding, 30 as well as the antibacterial activity when applied in skin wounds 22,24,31 that chitosan also displays. In a clinical trial, Azad et al 32 have shown a positive effect of chitosan both on the reepithelialization and regeneration of the granular layer of the skin where chitosan-dressed wounds healed faster compared to controls.…”

Section: Introductionmentioning

confidence: 83%

In VivoPerformance of Chitosan/Soy-Based Membranes as Wound-Dressing Devices for Acute Skin Wounds

Santos

Höring

Reise

et al. 2013

Tissue Engineering Part A

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Wound management represents a major clinical challenge on what concerns healing enhancement and pain control. The selection of an appropriate dressing plays an important role in both recovery and esthetic appearance of the regenerated tissue. Despite the wide range of available dressings, the progress in the wound care market relies on the increasing interest in using natural-based biomedical products. Herein, a rat wounddressing model of partial-thickness skin wounds was used to study newly developed chitosan/soy (cht/soy)-based membranes as wound-dressing materials. Healing and repair of nondressed, cht/soy membrane-dressed, and Epigard Ò -dressed wounds were followed macroscopically and histologically for 1 and 2 weeks. cht/soy membranes performed better than the controls, promoting a faster wound repair. Re-epithelialization, observed 1 week after wounding, was followed by cornification of the outermost epidermal layer at the second week of dressing, indicating repair of the wounded tissue. The use of this rodent model, although in impaired healing conditions, may enclose some drawbacks regarding the inevitable wound contraction. Moreover, being the main purpose the evaluation of cht/soy-based membranes' performance in the absence of growth factors, the choice of a clinically relevant positive control was limited to a polymeric mesh, without any growth factor influencing skin healing/repair, Epigard. These new cht/soy membranes possess the desired features regarding healing/repair stimulation, ease of handling, and final esthetic appearance-thus, valuable properties for wound dressings.

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Biological properties of the chitosan-gelatin sponge wound dressing

Cited by 125 publications

References 3 publications

Is Chitosan a New Panacea? Areas of Application

Is Chitosan a New Panacea? Areas of Application

Development and Characterization of Novel Medicated Hydrogels for Wound Dressing

In VivoPerformance of Chitosan/Soy-Based Membranes as Wound-Dressing Devices for Acute Skin Wounds

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