Biological Properties of the Aggregated Form of Chitosan Magnetic Nanoparticle

Paulino-Gonzalez, Angel David; Sakagami, Hiroshi; Bandow, Kenjiro; Kanda, Yoichi; Nagasawa, Y.; Hibino, Y.; Nakajima, Hiroshi; Yokose, Satoshi; Amano, Osamu; Nakaya, Giichirou; Koga‐Ogawa, Yukari; Shiroto, Akiyoshi; Nobesawa, Tadamasa; Ueda, Daisuke; Nakatani, Sachie; Kobata, Kenji; Iijima, Yosuke; Ifuku, Shinsuke; Yamamoto, Masaji; García-Contreras, René

doi:10.21873/invivo.11966

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…There was similar dose-dependent cytotoxic manner in OSCC and normal oral cell lines, which was biocompatible at low concentration (0.16–0.31 mg/mL), and cytotoxic at high concentration (1.25–40 mg/mL). Additionally, CS@IONPs showed synergism with 5-FU, abraxane and cisplatin in HSC-2 cells [ 75 ]. SPIONs coated with chitosan was used to delivery docetaxel, which was non-toxic to L929 cells at a concentration range of 100–1000 μg/mL.…”

Section: In Vitro Applications Of Ionpsmentioning

confidence: 99%

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Meng,

Shi,

Zhu

et al. 2024

J Nanobiotechnol

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The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable and low toxicity, such as anticancer, antibacterial, cell labelling activities. Nevertheless, there are few IONPs in clinical use at present. Some IONPs approved for clinical use have been withdrawn due to insufficient understanding of its biomedical applications. Therefore, a systematic summary of IONPs’ preparation and biomedical applications is crucial for the next step of entering clinical practice from experimental stage. This review summarized the existing research in the past decade on the biological interaction of IONPs with animal/cells models, and their clinical applications in human. This review aims to provide cutting-edge knowledge involved with IONPs’ biological effects in vivo and in vitro, and improve their smarter design and application in biomedical research and clinic trials. Graphical Abstract

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Section: In Vitro Applications Of Ionpsmentioning

confidence: 99%

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Meng,

Shi,

Zhu

et al. 2024

J Nanobiotechnol

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“…One of the most specific branches where chitosan coatings are used is dental and orofacial surgery. The substances and the use of chitosan-based coatings in surgery are presented in Table S1, [15,16,[44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] which is in the supplementary files.…”

Section: Surgical Proceduresmentioning

confidence: 99%

The Importance of Chitosan Coatings in Dentistry

Paradowska-Stolarz,

Mikulewicz,

Laskowska

et al. 2023

Marine Drugs

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A Chitosan is a copolymer of N-acetyl-D-glucose amine and D-glucose amine that can be easily produced. It is a polymer that is widely utilized to create nanoparticles (NPs) with specific properties for applications in a wide range of human activities. Chitosan is a substance with excellent prospects due to its antibacterial, anti-inflammatory, antifungal, haemostatic, analgesic, mucoadhesive, and osseointegrative qualities, as well as its superior film-forming capacity. Chitosan nanoparticles (NPs) serve a variety of functions in the pharmaceutical and medical fields, including dentistry. According to recent research, chitosan and its derivatives can be embedded in materials for dental adhesives, barrier membranes, bone replacement, tissue regeneration, and antibacterial agents to improve the management of oral diseases. This narrative review aims to discuss the development of chitosan-containing materials for dental and implant engineering applications, as well as the challenges and future potential. For this purpose, the PubMed database (Medline) was utilised to search for publications published less than 10 years ago. The keywords used were “chitosan coating” and “dentistry”. After carefully selecting according to these keywords, 23 articles were studied. The review concluded that chitosan is a biocompatible and bioactive material with many benefits in surgery, restorative dentistry, endodontics, prosthetics, orthodontics, and disinfection. Furthermore, despite the fact that it is a highly significant and promising coating, there is still a demand for various types of coatings. Chitosan is a semi-synthetic polysaccharide that has many medical applications because of its antimicrobial properties. This article aims to review the role of chitosan in dental implantology.

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Effects of Nitrurized Titanium on Microhardness and Human Dental Pulp Stem Cell Adhesion and Differentiation

Muñoz-Vazquez¹,

Chávez-Granados²,

Hernandez-Gomez³

et al. 2023

J Long Term Eff Med Implants

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To compare the Vickers microhardness, surface roughness, initial adhesion, and osteogenic differentiation on titanium (Ti) and nitrurized titanium (NTi) plates were treated by UV irradiation and chitosan. Each plate was subjected to Vickers hardness with a pressure of 2.9 N for 10 seconds and roughness evaluation by atomic force microscope (AFM) analysis. Three groups of each type of plates were tested: control (C), ultraviolet irradiation (UV), and chitosan (Q). The UV group was exposed to UV-irradiation for 20 min at 253.7 nm (52 μW/cm2). The Q group was coated with 1% chitosan, and the C group had no treatment. The osteoblasts (2 × 106 cells/mL) were inoculated in each group for 60 min and their viability was determined by the MTT bioassay. Osteogenic differentiation was performed over 4 weeks and determined by alizarin red staining. The mean was analyzed with the Shapiro-Wilks, Kruskall-Wallis, and Mann-Whitney U tests of normality (n = 9/gp). The NTi plates hardness (125.1 ± 4.01 HV) was higher (P = 0.026) than the Ti plates (121.3 ± 2.23 HV). The surface topography was: NTi (Ra = 0.098 μm) and Ti (Ra = 0.212 μm). The quantification of cell adhesion was: Ti + Q = 123 ± 4.9% (P < 0.05) < NTi + Q = 107 ± 3.3% < Ti = 100 ± 10.7% < NTi = 72 ± 6.8% < NTi + UV = 71 ± 4.4% < Ti + UV = 69 ± 3.5%, regardless the plates, the presence of chitosan induce a faster osteogenic differentiation. The Ti + Q plates tested the highest cell attachment and osteogenic adhesion suggesting their potential use of chitosan for cell-implant interaction.

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Biological Properties of the Aggregated Form of Chitosan Magnetic Nanoparticle

Cited by 3 publications

References 20 publications

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

Recent trends in preparation and biomedical applications of iron oxide nanoparticles

The Importance of Chitosan Coatings in Dentistry

Effects of Nitrurized Titanium on Microhardness and Human Dental Pulp Stem Cell Adhesion and Differentiation

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