Biological Properties of Iranian<i>Hypericum Scabrum</i>Essential oil and Hydroalcoholic Extract From Alamut Mountain

Dadkhah, Abolfazl; Roshanaei, Kambiz; Fatemi, Faezeh; Kazemi, Masoud; Alipour, Mahdi; Abdolmohammadi, Mohammad Hossein

doi:10.1080/0972060x.2013.764193

Cited by 8 publications

(8 citation statements)

References 52 publications

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“…Given the fact that these results represent the first report concerning H. sprucei essential oil, however, some considerations could be supported in light of the related literature about single compounds characterizing the isolated fractions. In fact, the important involvement of the compounds characterizing R f 0.3, as α -cadinol and α -muurolol, can be evidenced in antioxidant properties [ 19 ], analogously caryophyllene oxide, eugenol, elemicin, and methyleugenol for the fraction with R f 0.51 [ 20 , 21 ], and germacrene D and caryophyllene for R f 0.9 [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Effect and TLC Bioautography-Guided Approach to Detect Health Properties of AmazonianHedyosmum spruceiEssential Oil

Guerrini

Sacchetti

Grandini

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Bioautography has been used as rapid and easy strategy to detect and identify bioactive fractions/molecules in the never before investigated Hedyosmum sprucei Solms (Chloranthaceae) essential oil (EO). The antioxidant activity, performed through DPPH bioautographic assay and spectrophotometric evaluations (IC50 = 230 ± 10 µg/mL), seemed to be mainly due to α-cadinol and α-muurolol. (HP)TLC bioautography, focused on antimicrobial capacities, pointed out α-cadinol, α-muurolol, τ-muurolol, caryophyllene oxide, and methyleugenol as the most effective compounds against Staphylococcus aureus, considered as testing strain. Moreover, the microdilution method, assessed among a wide panel of microorganisms, revealed Listeria grayi and Staphylococcus aureus as the most sensitive among human tested strains and Clavibacter michiganensis among phytopathogens. GC-MS chemical profile showed that bioactive molecules represented only a small quantity of the whole EO: germacrene D (23.16%), β-caryophyllene (15.53%), δ-cadinene (5.50%), α-copaene (5.08%), and α-phellandrene (3.48%) were the main compounds, highlighting an uncommon composition among the genus Hedyosmum. Finally, H. sprucei EO was checked for cytotoxic potential against A549 (lung cancer) and MCF-7 (breast cancer) cell lines showing promising cytotoxic effects against both cell lines after 48 h (IC50 A549 = 44.05 ± 2.35 µg/mL; IC50 MCF-7 = 32.76 ± 4.92 µg/mL) and 72 h (IC50 A549 = 43.55 ± 2.80 µg/mL; IC50 MCF-7 = 33.64 ± 0.43 µg/mL).

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Section: Resultsmentioning

confidence: 99%

Cytotoxic Effect and TLC Bioautography-Guided Approach to Detect Health Properties of AmazonianHedyosmum spruceiEssential Oil

Guerrini

Sacchetti

Grandini

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…In addition, further biological effects of Hypericum EOs are gathered (in vitro: Antiviral, antimalarial, cytotoxic, neuroprotective, tyrosinase inhibitory, and immunomodulatory activities; in vivo: Anti-angiogenic, hepatoprotective, and wound-healing effects), attempting to bridge the potential relationship between traditional uses and Hypericum EOs' biological effects. Iran modulating effect on hepatic metabolizing enzymes in vivo in rats treated by acetaminophen [83] Iran hepatoprotective effects against oxidative stress induced by acetaminophen in vivo in rats [68] Iran antioxidant activity (DPPH and β-carotene assays) [82] Greece wound healing in vivo using SKH-hr1 mice [22] H. umbellatum A. Kern Serbia antibacterial activity (Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella abony, Staphylococcus aureus); antifungal activity (Aspergillus niger, Candida albicans) [41] Plant botanical authorities according to IPNI.…”

Section: Bioactivities From Hypericum Essential Oilsmentioning

confidence: 99%

“…EOs [17,19,20]. Since then, 71 papers have been published describing relevant research work [10,[14][15][16]18,, 34 of them referring to biological activities [20,22,24,32,34,[38][39][40][41][42]46,49,52,54,57,58,60,[62][63][64][65][66][67][68][69][70][71][72]74,77,79,82,83,86] of which antiviral, antimalarial, cytotoxic, neuroprotective, tyrosinase inhibition, immunomodulatory, anti-angiogenic, hepatoprotective, and wound-healing effects had not been tested earlier, thus later data are not described in previous reviews. As a result, we updated the latest information regarding Hypericum EOs' chemical composition and biological activities and we attempted to bridge the potential relationship between traditional uses and Hypericum EOs.…”

Section: Introductionmentioning

confidence: 99%

Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

et al. 2022

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Hypericum genus, considered to comprise over 500 species that exhibit cosmopolitan distribution, has attracted human interest since ancient times. The present review aims to provide and summarize the recent literature (2012–2022) on the essential oils of the title genus. Research articles were collected from various scientific databases such as PubMed, ScienceDirect, Reaxys, and Google Scholar. Scientific reports related to the chemical composition, as well as the in vitro and in vivo pharmacological activities, are presented, also including a brief outlook of the potential relationship between traditional uses and Hypericum essential oils bioactivity.

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“…Flavones, xanthones, flavonoids, and essential oils were established in Hypericum species [30]. The findings from the other investigation showed that the main compounds of H. scabrum oil were found as α-pinene, spathulenol, β-pinene, α-cadinol, limonene, and epi-α-muurolol has antioxidant activity [31].…”

Section: Introductionmentioning

confidence: 94%

Anatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potential

et al. 2022

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Hypericum (Hypericaceae) is a genus that comprises a high number of species around the world. In this study, the roots, aerial parts, flowers, fruits, and aerial parts with flowers from Hypericum scabrum were macerated separately by methanol and water and then fractionated by different solvents of, such as ethyl acetate, n-hexane, butanol, dichloromethane, aqueous residue sub-extracts, and ethnobotanical use. All the extracts, sub-extracts and essential oils of H. scabrum were investigated for the first time in detail for their antimicrobial, total phenolics, and antioxidant activities. Anatomical structures of the root, stem, leaf, upper and lower leaf surface, stamen, sepal, and petal of H. scabrum were examined. The biochemical layout of essential oils was determined by GC and GC/MS. The antioxidant activity was determined by free radical scavenging activity (by DPPH). Antimicrobial activity was applied against Candida albicans ATCC 10231, Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 19659, and C. tropicalis ATCC 750 using microdilution methods. The essentials of the aerial parts, flower, and fruit are characterized by the presence of monoterpene hydrocarbons, whereas roots oil include alkanes. The GC-FID and GC-MS analysis showed that major components of roots, aerial parts, flowers, and fruits oils were undecane (66.1%); α-pinene (17.5%), γ-terpinene (17.4%), and α-thujene (16.9%); α-pinene (55.6%), α-thujene (10.9%), and γ-terpinene (7.7%); α-pinene (85.2%), respectively. The aerial part sub-extracts indicated a greater level of total phenolics and antioxidant potential. The n-hexane sub-extracts (from aerial part, flower, and aerial part with flower) showed the best activity against B. subtilis, with 39.06 µg/mL MIC value. The presented research work indicates that H. scabrum can be a novel promising resource of natural antioxidant and antimicrobial compounds.

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Biological Properties of IranianHypericum ScabrumEssential oil and Hydroalcoholic Extract From Alamut Mountain

Cited by 8 publications

References 52 publications

Cytotoxic Effect and TLC Bioautography-Guided Approach to Detect Health Properties of AmazonianHedyosmum spruceiEssential Oil

Cytotoxic Effect and TLC Bioautography-Guided Approach to Detect Health Properties of AmazonianHedyosmum spruceiEssential Oil

Hypericum Essential Oils—Composition and Bioactivities: An Update (2012–2022)

Anatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potential

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