Biological properties of cardiac mesenchymal stem cells in rats with diabetic cardiomyopathy

Paula, Diógenes Rodrigo Maronezzi de; Capuano, Vanessa; Filho, Daniel Mendes; Carneiro, Anna Cecília Dias Maciel; Crema, Virgínia de Oliveira; Oliveira, Lucas Felipe de; Rodrigues, Aldo Rogelis Aquiles; Montano, Nicola; Silva, Valdo José Dias da

doi:10.1016/j.lfs.2017.08.034

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…Among these components, promising cell resources have been investigated to assess their characteristics, especially stemness capability, to provide fundamental knowledge for developing a mimic tissue or organ. Due to their affordable sample collection feature and non-tumorigenicity, multipotent stem cells from various tissues derived from bone marrow, umbilical cord, amniotic fluid, adipose tissue, muscle, dental tissue [ 7 8 ], skin [ 9 ], kidney [ 10 ], liver [ 11 ], heart [ 12 ], and brain [ 13 ] have been investigated. In this regard, a common source of multipotent stem cells is bone marrow mesenchymal stem cells (BM-MSCs), which have been proposed and described as a promising cell resource from various animal sources, including avian [ 14 ], murine [ 15 16 ], rat [ 17 ], rabbit [ 18 ], feline [ 19 ], canine [ 20 ], ovine [ 21 ], bovine [ 22 ], porcine [ 23 ], equine [ 24 ], non-human primate [ 24 ], and human [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative characteristic study from bone marrow-derived mesenchymal stem cells

et al. 2021

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Tissue engineering has been extensively investigated and proffered to be a potential platform for novel tissue regeneration. The utilization of mesenchymal stem cells (MSCs) from various sources has been widely explored and compared. In this regard, MSCs derived from bone marrow have been proposed and described as a promising cell resource due to their high yield of isolated cells with colony-forming potential, self-renewal capacity, MSC surface marker expression, and multi-lineage differentiation capacities in vitro . However, there is evidence for bone marrow MSCs (BM-MSCs) both in vitro and in vivo from different species presenting identical and distinct potential stemness characteristics. In this review, the fundamental knowledge of the growth kinetics and stemness properties of BM-MSCs in different animal species and humans are compared and summarized. Finally, to provide a full perspective, this review will procure results of current information studies focusing on the use of BM-MSCs in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Comparative characteristic study from bone marrow-derived mesenchymal stem cells

et al. 2021

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“…MSCs have also been shown to display an increased tendency to differentiate into adipocytes in diabetic states, which may contribute to the disease burden [95,97,122]. In addition, the increased tendency of diabetic MSCs to differentiate into adipocytes is often coupled with reduced differentiation into osteoblasts, which has been suggested as the cause of the increased bone fractures and osteoporosis in diabetic patients [123,124]. Thirdly, the delicate balance of factors implicated in angiogenesis is well-known to be altered in the diabetic state [94].…”

Section: Mscs Dysfunction In Systemic Diseases and Agingmentioning

confidence: 99%

Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities

Vizoso

Eiró

Costa

et al. 2019

IJMS

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Mesenchymal stem cells (MSCs) are present in all organs and tissues, playing a well-known function in tissue regeneration. However, there is also evidence indicating a broader role of MSCs in tissue homeostasis. In vivo studies have shown MSC paracrine mechanisms displaying proliferative, immunoregulatory, anti-oxidative, or angiogenic activity. In addition, recent studies also demonstrate that depletion and/or dysfunction of MSCs are associated with several systemic diseases, such as lupus, diabetes, psoriasis, and rheumatoid arthritis, as well as with aging and frailty syndrome. In this review, we hypothesize about the role of MSCs as keepers of tissue homeostasis as well as modulators in a variety of inflammatory and degenerative systemic diseases. This scenario opens the possibility for the use of secretome-derived products from MSCs as new therapeutic agents in order to restore tissue homeostasis, instead of the classical paradigm “one disease, one drug”.

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“…Hence, the application of mesenchymal stem cells (MSCs) has been investigated for bone tissue engineering utilization (Amini et al., 2012). Isolations of MSCs from various tissue resources have been reported for example bone marrow (Bianco et al., 2001; Macrin et al., 2017), adipose tissues (Zuk et al., 2002), dental tissues (Miura et al., 2003; Shi and Gronthos, 2003), umbilical cord blood (Rosada et al., 2003), peripheral blood (Kuznetsov et al., 2001), amniotic fluid (In 't Anker et al., 2004), brain (Crisan et al., 2008; Lojewski et al., 2015), skin (Joannides et al., 2004), heart (de Paula et al., 2017), kidney (Leuning et al., 2017a, b), and liver (El-Kehdy et al., 2016). In this review, potential application of three main MSCs in veterinary bone tissue engineering namely a) bone marrow-derived MSCs (BM-MSCs), b) adipose-derived MSCs (AD-MSCs), and c) dental tissue-derived MSCs, is discussed.…”

Section: Msc-based Bone Tissue Engineering For Veterinary Practicementioning

confidence: 99%

Mesenchymal stem cell-based bone tissue engineering for veterinary practice

Nantavisai

Egusa

Osathanon

et al. 2019

Heliyon

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Bone tissue engineering has been widely studied and proposed as a promising platform for correcting the bone defects. The applications of mesenchymal stem cell (MSC)-based bone tissue engineering have been investigated in various in vitro and in vivo models. In this regard, the promising animal bone defect models have been employed for illustrating the bone regenerative capacity of MSC-based bone tissue engineering. However, most studies aimed for clinical applications in human. These evidences suggest a knowledge gap to fulfill the accomplishment for veterinary implementation. In this review, the fundamental concept, knowledge, and technology of MSC-based bone tissue engineering focusing on veterinary applications are summarized. In addition, the potential canine MSCs resources for veterinary bone tissue engineering are reviewed, including canine bone marrow-derived MSCs, canine adipose-derived MSCs, and canine dental tissue-derived MSCs. This review will provide a basic and current information for studies aiming for the utilization of MSC-based bone tissue engineering in veterinary practice.

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Biological properties of cardiac mesenchymal stem cells in rats with diabetic cardiomyopathy

Cited by 9 publications

References 34 publications

Comparative characteristic study from bone marrow-derived mesenchymal stem cells

Comparative characteristic study from bone marrow-derived mesenchymal stem cells

Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities

Mesenchymal stem cell-based bone tissue engineering for veterinary practice

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