Biological Properties of 1H-1,2,3- and 2H-1,2,3-Triazoles

Silva, Fernando de Carvalho da; Cardoso, Mariana F. C.; Ferreira, Patrícia; Ferreira, Vı́tor F.

doi:10.1007/7081_2014_124

Cited by 40 publications

(14 citation statements)

References 280 publications

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“…A large number of heterocycles containing an embedded triazole core have attracted considerable attention because of their broad range of pronounced biological activity. For example, 1,2,3-triazole derivatives exhibit anti-inflammatory, anesthetic, antimicrobial, anti-arrhythmic, antitumor, and antiviral properties [14][15][16][17]. In addition, 1,2,3-triazole derivatives are used in agrochemistry as insecticides, fungicides and plant growth regulators [18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent

Tsyrenova

Nenajdenko

2020

Molecules

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Efficient synthesis of 2,5-diaryl substituted 4-azido-1,2,3-triazoles by the reaction of sodium azide with dichlorosubstituted diazadienes was demonstrated. The optical properties of the prepared azidotriazoles were studied to reveal a luminescence maximum in the 360–420 nm region. To improve the luminescence quantum yields a family of 4-azido-1,2,3-triazoles bearing ortho-propargyloxy substituents in the 5 position was prepared. Subsequent intramolecular thermal cyclization permits to construct additional triazole fragment and obtain unique benzoxazocine derivatives condensed with two triazole rings. This new family of condensed heterocycles has a flattened heterocyclic system structure to provide more conjugation of the 5-aryl fragment with the triazole core. As a result, a new type of UV/“blue light-emitting” materials with better photophysical properties was obtained.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent

Tsyrenova

Nenajdenko

2020

Molecules

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“…Among other heterocycles, triazoles are one of the most attractive and popular objects of research. These heterocyclic cores are one of the most common pharmacophores . For example, triazoles exhibit insecticidal and herbicidal activities and are known as fungicides and plant growth regulators in agrochemistry .…”

Section: Introductionmentioning

confidence: 99%

2H-Bis-1,2,3-triazolo-isoquinoline: Design, Synthesis, and Photophysical Study

2020

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An efficient three-step synthesis of a new heterocyclic system is described wherein the 2H-bis([1,2,3]triazolo)[5,1-a:4′,5′-c]isoquinoline ring system is elaborated using a simple synthetic strategy. The approach permits the preparation of target compounds in high yields using readily available arylhydrazines and o-alkynylbenzaldehydes as starting materials. The photophysical properties of the prepared heterocycles were studied to demonstrate that the prepared compounds are attractive blue-emitting fluorophores, exhibiting quantum yields up to 98% and Stokes shifts up to 67 nm. A strong effect of the steric hindrance on the absorption and emission spectra was revealed.

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“…The interest in incorporation of [1,2,3]-triazole moiety stems from the advent of click chemistry protocol [17,18], which has been used in various applications including drug discovery process. In addition, triazole embedded heterocyclic frameworks exhibit plethora of biological activities, especially antimycobacterial activity (figure 1) [19][20][21][22]. Furthermore, these triazole products are considered as aggressive pharmacophores that can actively engage in drug-receptor interactions while maintaining an excellent chemical and metabolic profile [23].…”

Section: Introductionmentioning

confidence: 99%

Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents

et al. 2018

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A series of 20 novel chromone embedded [1,2,3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56–12.5 µg ml−1. Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56 µg ml−1. Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like properties against the enoyl-acyl carrier protein reductase of M. tuberculosis further establishing its potential as a potent inhibitor.

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Biological Properties of 1H-1,2,3- and 2H-1,2,3-Triazoles

Cited by 40 publications

References 280 publications

Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent

Synthesis and Spectral Study of a New Family of 2,5-Diaryltriazoles Having Restricted Rotation of the 5-Aryl Substituent

2H-Bis-1,2,3-triazolo-isoquinoline: Design, Synthesis, and Photophysical Study

Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents

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