Biological Profile of Quingestanol Acetate

NTP Research Report on the Scoping Review of Prenatal Exposure to Progestogens and Adverse Health Outcomes

“…Significant findings were reported in 13 animal studies evaluating AGD following prenatal progestogen exposure and two studies that reported effects of progestogens but did not conduct statistics (Giannia et al 1969;Johnstone and Franklin 1964) (Figure 7). The direction of the effect was consistent with in utero exposure to progestogens lengthening the AGD of female offspring (Foote et al 1968;Gandelman et al 1981;Giannia et al 1969;Johnstone and Franklin 1964;Prahalada et al 1985a;Prahalada et al 1985b;Whalen et al 1966) and shortening the AGD in male offspring (Gupta and Goldman 1986;Scouten et al 1975). Similar effects were reported across species (mice, rats, guinea pigs, baboons, and cynomolgus monkeys) and across synthetic progestogen exposures with known anti-androgenic (e.g., cyproterone acetate) or androgenic effects (e.g., MPA, norethindrone, norethindrone acetate, quingestanol acetate).…”

Estrogenic Properties of Quinestrol and Estradiol-17 in the Ovariectomized Rhesus Monkey

“…I t is not certain if the 22 days to bleeding after a single oral quinestrol treatment denotes a prolongation of estrogenic responses as seen for sustained action injectable steroids (9). Single oral quinestrol treatments in rats and women (4,11) have shown an increasing prolongation of response as doses are increased; and similar evidence for certain estrogen injections in monkeys is also available (9).…”

The Biological Profile of Three 19-Nortestosterone-3-Cyclopentyl Enol Ethers

“…Though many studies on enol ether analogues of progesterone (2)(3)(4)(5)(6)(7) and certain androgens (2,7,(8)(9)(10)(11) have been reported, little is known about similar derivatives of 19-nortestosterone. Experiments with the 3-cyclopentyl enol ether of 17aethynyl-19-nortestosterone-l7p-acetate [ quingestanol acetate (QA)] showed that enol etherification generally enhances most biological activities as compared with its parent ketone (2,4,5,7,12). Substitution of a methyl or ethyl group for the ethynyl group and replacement of the acetate by a hydroxyl group has provided two additional enol ethers, 17a-methyl-19-nortestosterone-3-cyclopentyl enol ether (MCPE) and 17a-ethyl-19nortestosterone-3-cyclopentyl enol ether (EC PE) for this comparative study.…”