Estrogenic Properties of Quinestrol and Estradiol-17  in the Ovariectomized Rhesus Monkey

Survey and Assessment of Mammalian Estrogen Biological Assays for Hazard Characterization

“…Taken together, the data indicated that EE, mestranol, E,, and Premarin were approximately equipotent, whereas DES was of lesser potency in the withdrawal bleeding assay. Hisaw et al (1971) evaluated quinestrol in the rhesus monkey withdrawal bleeding assay. Quinestrol, the 3-cyclopentyl ether of EE, has prolonged estrogenic activity by virtue of its storage in, and subsequent release from, body fat.…”