Biological Products: Cellular Therapy and FDA Approved Products

Golchin, Ali; Farahany, Tahereh Zarnoosheh

doi:10.1007/s12015-018-9866-1

Cited by 114 publications

(90 citation statements)

References 59 publications

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“…Currently, cell-based therapy and especially stem cell therapy has become a promising therapeutic field, in which many see opportunities to cure incurable diseases [22]. Despite the significant development of the stem cell-based therapy field, immunogenicity, limited cell source and ethical issue as the main limitations of this therapeutic approach have not been solved yet.…”

Section: Mesenchymal Stem Cell Therapymentioning

confidence: 99%

Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

Golchin

Seyedjafari

Ardeshirylajimi

2020

Stem Cell Rev and Rep

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294

302

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" is the word that certainly isn't forgotten by everybody who lives in the first half of the twenty-first century. COVID-19, as a pandemic, has led many researchers from different biomedical fields to find solutions or treatments to manage the pandemic. However, no standard treatment for this disease has been discovered to date. Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. After the intravenous transplantation of MSCs, a significant population of cells accumulates in the lung, which they alongside immunomodulatory effect could protect alveolar epithelial cells, reclaim the pulmonary microenvironment, prevent pulmonary fibrosis, and cure lung dysfunction. Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. In this study, we considered this new approach to improve patient's immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing.

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Section: Mesenchymal Stem Cell Therapymentioning

confidence: 99%

Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

Golchin

Seyedjafari

Ardeshirylajimi

2020

Stem Cell Rev and Rep

Self Cite

294

302

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“…When it comes to finding effective and safe cures for the patients suffering from COVID-19, the research hypotheses were set generally around the idea that MSCs as treatment agents can be effective to prevent the cytokines' storm over the immune system and to promote tissue repair endogenously by reparative capabilities of these cells. When infused in intravenous route, MSCs joins to the pulmonary tissue and induce the recovery of the pulmonary cellular level impairment and treat lung dysfunction and COVID-19 pneumonia [19,56].…”

Section: Stem Cells As An Option Curing Sars-cov Induced Pulmonary Immentioning

confidence: 99%

Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?

Irmak¹,

Darıcı²,

Karaöz³

2020

Aging and disease

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The COVID-19 patients were first detected in China, in December 2019, then the novel virus with associated pneumonia and other diseases spread quickly to worldwide becoming a serious public health intimidation. Despite all the efforts, the pharmacological agents used for controlling or treating the disease, especially respiratory problems, have not been accomplished so far. Among various treatment options, mesenchymal stem cell-based cellular therapies are being investigated, because of their regeneration ability and multipotency along with other features like immunomodulation, antifibrosis and anti-inflammatory effects. This paper intends to analyze the current clinical trials on stem cell treatment of novel virus, searching and reviewing the available information and the International Clinical Trials Registry Platform (ICTRP) of World Health Organization (WHO). We concluded that the stem cell treatment of COVID-19 is found promising with pilot studies' results, but still in the early development phase. There is an urgent need for large-scale investigations to confirm and validate the safety and efficacy profile of these therapies with reliable scientific evidence.

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“…These considerations are especially relevant for bioactive components, which may include elements such as cells, DNA, extracellular matrix proteins, or growth factors. Many exciting advances in the use of bioactive components for precision medicine have already been implemented in clinical settings for non‐3D printing applications, such as personalized gene therapies or matrix‐induced autologous chondrocyte implantation . Further, advances in gene therapy, cell culture, and cell manufacturing offer an array of exciting new components to incorporate into bioinks for precision medicine .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

2019

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Advances in areas such as data analytics, genomics, and imaging have revealed individual patient complexities and exposed the inherent limitations of generic therapies for patient treatment. These observations have also fueled the development of precision medicine approaches, where therapies are tailored for the individual rather than the broad patient population. 3D printing is a field that intersects with precision medicine through the design of precision implants with patient‐directed shapes, structures, and materials or for the development of patient‐specific in vitro models that can be used for screening precision therapeutics. Toward their success, advances in 3D printing and biofabrication technologies are needed with enhanced resolution, complexity, reproducibility, and speed and that encompass a broad range of cells and materials. The overall goal of this progress report is to highlight recent advances in 3D printing technologies that are helping to enable advances important in precision medicine.

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Biological Products: Cellular Therapy and FDA Approved Products

Cited by 114 publications

References 59 publications

Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

Mesenchymal Stem Cell Therapy for COVID-19: Present or Future

Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

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