Biological Planning Optimization for High‐dose‐rate Brachytherapy and Its Application to Cervical Cancer Treatment

Paradigm shift in radiation treatment planning over multiple treatment modalities

“…Popular models include the linear-quadratic model, biological effective dose, equivalent dose in 2 Gy fractions (EQD2), equivalent uniform dose, the Lyman–Kutcher–Burman model, the Poisson model, tumor control probability, and normal tissue complication probability. [ 5 6 7 8 9 10 11 12 ] These models map a physical dose onto a space that accounts for cell type, DNA repair capabilities, cell proliferation rates, and fractionation scheme. In this way, constraints on the dose delivered to organs at risk (OARs) can be tabulated independent of fractionation scheme and delivery type.…”