“…The marker used most often is oligoclonal IgG bands in cerebrospinal fluid with sensitivity of >90%, but low specificity of ~35% and the need for cerebrospinal fluid samples [16,17]. The most reliable serum markers of MS are antibodies to myelin oligodendrocyte glycoprotein (MOG) or myelin basic protein (MBP) that provide specificity and sensitivity in the range of 60 to 85% [18,19]. The combination of antibody testing towards MOG, MBP and α-βcrystallin, with the diagnostic criteria being the presence of 2 out of 3 parameters, provides a specificity of 80-95% and sensitivity of 40-60% [20].…”