Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know?

Fontana, Josef; Zima, M; Větvička, Václav

doi:10.1080/08820139.2018.1523925

Cited by 20 publications

(8 citation statements)

References 93 publications

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“…Considering that there are promising studies looking to use low doses of IL-2 in ischaemic heart disease, 35,36 data obtained by this study open new perspectives in the process of the elucidation of its effects. In this direction, the basic hallmark would be on the signalling pathways involving NF-κB.…”

Section: Discussionmentioning

confidence: 86%

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca²⁺ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Mitrokhin

Горбачева

Vachrushev

et al. 2020

Basic Clin Pharma Tox

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The main objective of this study was to determine the primary intracellular signalling pathway affected by prolonged (2 hours) incubation in interleukin-2 (IL-2). Based on the inflammatory nature of IL-2, priority was given to the involvement of inhibitory-kappaB kinase/nuclear factor-kappaB (IKK/NF-κB) signalling. All of the experiments were performed on freshly prepared cardiomyocytes isolated from rat left ventricles. After isolation, the whole-cell voltage-clamp recordings were performed on single cells. After 2 hours of incubation in IL-2, the current at 0 mV was approximately 100% higher than at the start of the incubation. ACHP, a highly specific kinase β inhibitor, in a concentration of 10 nmol/L, caused significant reduction in the I Ca,L. IL-2 (2 ng/mL) in the presence of 0.1 μmol/L IMD-0354 as a specific inhibitor of IKKβ, caused nearly no changes in the I Ca,L. IL-2 (3 ng/mL) induced a significant increase in phosphorylated NF-κB p65. The cardiomyocytes incubated in a Kraftbrühe solution containing IL-2 plus PDTC as a specific inhibitor of inducible nitric oxide synthase (iNOS) for 2 hours had a similar I Ca,L increase compared to the cells incubated only in IL-2. IL-2-induced enhancement in L-type Ca 2+ channels was mediated by IKK/NF-κB signalling, but not via iNOS-mRNA signalling.

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Section: Discussionmentioning

confidence: 86%

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca²⁺ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Mitrokhin

Горбачева

Vachrushev

et al. 2020

Basic Clin Pharma Tox

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“…The second one suggested the opposite and involves increased production of antioxidants, which might favour a tumour-potentiating environment. Both options are based on the idea of the double-edged sword of redox imbalance [51]. Additional risk factors might involve age over 42 years and post-menopause status [52].…”

Section: Ovarian Cancermentioning

confidence: 99%

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Větvička¹,

Fiala²,

Garzon³

et al. 2021

Self Cite

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Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10-16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.

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“…Второй сценарий предполагает постоянное производство антиоксидантов, что способствует поддержанию опухолевой среды. Оба варианта поддерживают теорию окислительно-восстановительного дисбаланса [38].…”

Section: рис 1 различные механизмы предлагаемые для объяснения злокачественной трансформации эндометриоза (по гранди и др)unclassified

Эндометриоз И Риск Развития Рака Яичников

Мамедова¹,

Леваков²,

Гелашвили³

et al. 2021

Наука России: Цели И Задачи

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Несмотря на длительные и интенсивные исследования, эндометриоз остаѐтся одной из основных причин заболеваемости женщин в фертильном возрасте и пременопаузе. Большинство связанных с эндометриозом яичниковых карцином возникает при атипичном эндометриозе яичников. Тем не менее, несмотря на возросшую заболеваемость раком яичников у пациентов с эндометриозом, знания о факторах риска и механизмах развития все ещѐ не полностью изучены. Метод. Краткий обзор, обобщающий недавние выводы литературы, извлечѐнных из баз данных. Полученные результаты. Здесь рассматриваются и суммируются самые последние знания, касающиеся эндометриоза и рака яичников. Заключение. Доказательства того, что пациенты с эндометриозом имеют более высокий риск развития рака яичников, убедительны. Однако вопрос о том, насколько высок абсолютный риск развития злокачественной трансформации, не полностью понятен.

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Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know?

Cited by 20 publications

References 93 publications

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca²⁺ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca²⁺ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Эндометриоз И Риск Развития Рака Яичников

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Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know?

Cited by 20 publications

References 93 publications

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca2+ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca2+ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Endometriosis and gynaecological cancers: molecular insights behind a complex machinery

Эндометриоз И Риск Развития Рака Яичников

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Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca²⁺ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling

Cardiomyocytes' prolonged IL‐2 incubation induces enhancement in L‐type Ca²⁺ channels mediated by inhibitory‐kappaB kinase/nuclear factor‐kappaB signalling