Biological investigations on macro-morphological characteristics, polyphenolic acids, antioxidant activity of Perilla frutescens (L) Britt. grown under open field

Ahmed, Hiwa M.; Al-Zubaidy, Adel Mohan Aday; Othman-Qadir, Gashaw

doi:10.1016/j.sjbs.2022.01.059

Cited by 11 publications

(3 citation statements)

References 47 publications

(68 reference statements)

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“…Frutescens (PF), also known as ‘Zisu’ in Chinese, ‘Cha-jo-ki’ or ‘So-yeop’ in Korean, and ‘Jiso’ in Japanese, is an important food ingredient and medicinal plant in East Asia ( Kim et al, 2017 ). Its recognized bioactivities include antioxidant action Meng et al, 2008 ; Takahashi et al, 2011 ; Ahmed et al, 2022 ), immune control ( Kwon et al, 2002 ), skin wound healing ( Kim et al, 2021 ), anti-glomerulonephritis action ( Makino et al, 2001 ), and anti-arthritis action ( Jin et al, 2019 ). In particular, a marker compound named “Isoegomaketone” from PF has an excellent anti-inflammatory response ( Kim et al, 2020 ), which is effective for treating arthritis and joint swelling ( Jin et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial

Kim

et al. 2023

Front. Pharmacol.

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Objectives: This study aimed to evaluate the clinical efficacy and safety of PE extracts developed for the purpose of relieving pain and improving knee joint function on semi-healthy people with mild knee joint pain.Methods: A randomized, double-blind, two-arm, single-center, placebo-controlled clinical trial was conducted. Individuals with knee joint pain and a visual analogue scale (VAS) score < 50 mm were included in the study, and participants with radiological arthritis were excluded. Participants were administered either PFE or a placebo capsule (700 mg, twice a day) orally for eight weeks. The comparisons of the changed VAS score and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scores between the PFE and placebo groups were primary outcomes, while the five inflammation-related laboratory tests including cartilage oligomeric matrix protein, cyclooxygenase-2, neutrophil and lymphocyte ratio, high sensitive C-reactive protein, and erythrocyte sedimentation rate were secondary outcomes. Also, a safety assessment was done.Results: Eighty participants (mean age, 38.4 ± 14.0, male: female, 28:52) were enrolled; 75 completed the trial (PFE 36 and placebo 39). After eight weeks, both VAS and WOMAC scores were reduced in the PFE and placebo groups. The changed scores were significantly higher in the PFE group compared to the placebo group: 19.6 ± 10.9 vs. 6.8 ± 10.5; VAS scores (p < 0.001), and 20.5 ± 14.7 vs. 9.3 ± 16.5; total WOMAC scores (p < 0.01) including the sub-scores for pain, stiffness, and functions. No significant changes were reported in the five inflammation-related laboratory parameters. All adverse events were considered minor and unlikely to result from the intervention.Conclusion: Eight weeks of PFE intake was more effective than placebo in reducing knee joint pain and improving knee joint function in sub-healthy people with mild knee joint pain, and there were no major safety concerns.Clinical Trial Registration:https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=M&pageSize=10&page=undefined&seq=23101&status=5&seq_group=19745, identifier CRIS: KCT0007219

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Section: Introductionmentioning

confidence: 99%

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial

Kim

et al. 2023

Front. Pharmacol.

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“…Perilla frutescens (L.) a significant cooking spice and medicinal herb, is prevalent in various Asian countries, including China, Thailand, India, and Japan. [ 35 ]. Contemporary research has shown that P. frutescens essential oil exhibits a broad range of biological activities including antibacterial, antioxidant, antidepressant, anti-inflammatory and intestinal-promoting [ 36 – 39 ].…”

Section: Introductionmentioning

confidence: 99%

Applying quantitative spatial phenotypes analysis to the investigation of peltate glandular trichomes development pattern in Perilla frutescens

Jiang,

Zhou,

Shao

et al. 2023

Plant Methods

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Background Glandular trichomes, often referred to as “phytochemical factories”, plays a crucial role in plant growth and metabolism. As the site for secretion and storage, the development of glandular trichomes is related to the dynamic biosynthesis of specialised metabolites. The study aims to explore the relationship between spatial phenotype and dynamic metabolism of glandular trichomes, and establish a novel approach for the exploration and study of the regulatory mechanism governing the development of glandular trichomes. Results In this study, we proposed a technical route based on the relative deviation value to distinguish the peltate glandular trichomes (PGTs) from the background tissues and extract their spatial phenotype. By defining glandular trichome developmental stages based on the leaf vein growth axis, we found that young PGTs were densely distributed near the proximal end of growth axis of the leaf veins, where perillaketone, a primary metabolite of PGTs, is predominantly accumulated. Conversely, mature PGTs are typically found near the distal end of the mid-vein growth axis and the lateral end of the secondary vein growth axis, where the accumulation rate of isoegomaketone and egomaketone exceeds that of perillaketone in PGTs. We further identified spatial phenotypic parameters, Lsum and d, as independent variables to construct a linear regression model that illustrates the relationship between the spatial phenotypes and metabolite content of PGTs, including perillaketone (R2 = 0.698), egomaketone (R2 = 0.593), isoegomaketone (R2 = 0.662) and the sum of the amount (R2 = 0.773). Conclusions This model proved that the development of PGTs was correlated with the growth of the entire leaf, and the development stage of PGTs can be identifined by spatial phenotypes based on the leaf veins. In conclusion, the findings of this study enhance our understanding of correlation between spatial phenotype and development of glandular trichomes and offer a new approach to explore and study the regulatory mechanism of glandular trichome development.

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“…Perilla frutescens is an annual herb belonging to the genus Perilla, Lamiaceae. e main types of perilla are red (purple), green, and red/green perilla phenotypes with high polymorphism in morphology and taxonomy [5]. It is a traditional Chinese medicine with a history of more than 2000 years of use [6,7].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Pharmacological Activities and Effects of Perilla Ketone and Isoegomaketone

Wang

Zhang

Feng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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As components of a traditional Chinese herbal medicine with many physiological activities, perilla ketone and isoegomaketone isolated from perilla essential oil are important active components of Perilla frutescens. Recent studies have shown that these two compounds have promising antitumor, antifungal, antirheumatoid arthritis, antiobesity, anti-inflammatory, healing-promoting, and other activities and can be used to combat toxicity from immunotherapy. Therefore, the multitude of pharmacological activities and effects demonstrate the broad research potential of perilla ketone and isoegomaketone. However, no reviews have been published related to the pharmacological activities or effects of perilla ketone and isoegomaketone. The purpose of this review is as follows: (1) outline the recent advances made in understanding the pharmacological activities of perilla ketone and isoegomaketone; (2) summarize their effects; and (3) discuss future research perspectives.

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Biological investigations on macro-morphological characteristics, polyphenolic acids, antioxidant activity of Perilla frutescens (L) Britt. grown under open field

Cited by 11 publications

References 47 publications

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial

Applying quantitative spatial phenotypes analysis to the investigation of peltate glandular trichomes development pattern in Perilla frutescens

Advances in the Pharmacological Activities and Effects of Perilla Ketone and Isoegomaketone

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