Advances in the Pharmacological Activities and Effects of Perilla Ketone and Isoegomaketone

Wang, Ruo; Zhang, Qianru; Feng, Chengling; Zhang, Juzhao; Qin, Yuxuan; Meng, Linghua

doi:10.1155/2022/8809792

Cited by 10 publications

(8 citation statements)

References 86 publications

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“…Studies have demonstrated that limonene has good inhibitory effects for Colletotrichum falcatum , Staphylococcus aureus , Aspergillus niger, and Listeria monocytogenes [ 29 ]. Wang et al also reported that perilla ketones isolated from perilla essential oil are important antifungal components [ 30 ]. Tian et al reported that perillaldehyde was the main antifungal component in PEO [ 31 ], but it was not detected in the current study.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Perilla frutescens Essential Oil on Pellicle Formation of Candida tropicalis and Pichia kluyveri and Its Effect on Volatile Compounds in Sichuan Pickles

Cai

Shi

Zhang

et al. 2023

Foods

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Pellicle formation is the most typical characteristic of deteriorating fermented vegetable products. Perilla frutescens essential oil (PEO) is widely used as a useful natural preservative. However, few studies have addressed the antifungal activity and mechanism of PEO in pellicle formation microorganisms, and it is still unclear whether it can inhibit pellicle formation and affect its volatile compounds in Sichuan pickles. The current study showed that PEO can inhibit pellicle formation during fermentation of Sichuan pickles as it had significant antifungal activity against the pellicle formation microorganisms Candida tropicalis SH1 and Pichia kluyveri SH2. The minimum inhibitory concentration (MIC) of PEO against C. tropicalis SH1 and P. kluyveri SH2 was determined to be 0.4 μL/mL, and the minimum fungicidal concentrations (MFCs) were 1.6 μL/mL and 0.8 μL/mL, respectively. The antifungal mechanism was activated as a result of damage to the cell membrane, an increase in the cell permeability, a decrease in the mitochondrial membrane potential, and the inhibition of ATPase activity. Meanwhile, the addition of PEO to Sichuan pickles can enrich the profiles of volatile compounds during fermentation, including limonene, myrcene, 1,8-cineole, linalool, perilla ketone, heptanal, hexanal, α-thujone and β-terpineol and thus improve the overall sensory acceptability. These results indicated that PEO has the potential to be used as a novel food preservative to control pellicle formation in fermented vegetables.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Perilla frutescens Essential Oil on Pellicle Formation of Candida tropicalis and Pichia kluyveri and Its Effect on Volatile Compounds in Sichuan Pickles

Cai

Shi

Zhang

et al. 2023

Foods

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“…Although a variety of treatments are already used for the treatment of cancer, more treatments still need to be developed [120][121][122][123]. Exosomes are independent units with a complete membrane structure.…”

Section: Exosomes In Bc Treatmentmentioning

confidence: 99%

Biological Roles and Clinical Applications of Exosomes in Breast Cancer: A Brief Review

Wang,

Shen

et al. 2024

IJMS

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Breast cancer (BC) is a global health risk for women and has a high prevalence rate. The drug resistance, recurrence, and metastasis of BC affect patient prognosis, thus posing a challenge to scientists. Exosomes are extracellular vesicles (EVs) that originate from various cells; they have a double-layered lipid membrane structure and contain rich biological information. They mediate intercellular communication and have pivotal roles in tumor development, progression, and metastasis and drug resistance. Exosomes are important cell communication mediators in the tumor microenvironment (TME). Exosomes are utilized as diagnostic and prognostic biomarkers for estimating the treatment efficacy of BC and have the potential to function as tools to enable the targeted delivery of antitumor drugs. This review introduces recent progress in research on how exosomes influence tumor development and the TME. We also present the research progress on the application of exosomes as prognostic and diagnostic biomarkers and drug delivery tools.

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“…The compounds derived from Perilla frutescens exhibit various functions, such as anti-allergic, anti-inflammatory, antioxidant, anticancer, antibacterial, and antidepressant properties [ 1 , 7 , 8 , 9 , 10 ]. However, many of these properties were demonstrated in animal or in vitro studies.…”

Section: Introductionmentioning

confidence: 99%

Applications of Perilla frutescens Extracts in Clinical Practice

et al. 2023

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(1) Background: Perilla frutescens (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects is poorly outlined. The aim of this review was to provide an updated and thorough understanding of Perilla frutescens applications in clinical practice using data derived from human studies, and to outline the potential directions and perspectives for further studies on this crop. (2) Methods: Medline, Embase, and Cochrane databases were used to find relevant studies. All interventional studies that evaluated the effect of Perilla frutescens in human subjects were assessed. (3) Results: The main perspectives that can be contoured from the presented literature evaluation are an important clinical effect of Perilla frutescens extracts on allergic rhinoconjuctivitis, especially in young populations, a potent hypolipemiant effect that, in conjunction with increased serum biological antioxidant potential, determines significant improvements in cognitive function and a wide variety of miscellaneous clinical effects that need further exploration. (4) Conclusions: Supplementary research is needed in order to demonstrate the therapeutic effects of Perilla frutescens in controlled clinical settings.

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Advances in the Pharmacological Activities and Effects of Perilla Ketone and Isoegomaketone

Cited by 10 publications

References 86 publications

Inhibition of Perilla frutescens Essential Oil on Pellicle Formation of Candida tropicalis and Pichia kluyveri and Its Effect on Volatile Compounds in Sichuan Pickles

Inhibition of Perilla frutescens Essential Oil on Pellicle Formation of Candida tropicalis and Pichia kluyveri and Its Effect on Volatile Compounds in Sichuan Pickles

Biological Roles and Clinical Applications of Exosomes in Breast Cancer: A Brief Review

Applications of Perilla frutescens Extracts in Clinical Practice

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