Biological importance of structurally diversified chromenes

First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones

“…After that period, the crude was dissolved in CH 2 Cl 2 (5 mL) and purified using preparative TLC using hexane/EtOAc (9:7) as the eluent. Synthesis of (E)-2-(2-allyloxystyryl)-4H-chromen-4-one (15). To a mixture of sodium (110 mg, 5 mmol) in ethanol (5 mL) was added the 2-methylchromone 2a (200 mg, 1.25 mmol) and the O-allyloxybenzaldehyde 14 (253 mg, 1.56 mmol).…”

“…The effect of the addition of a series of Lewis acids was evaluated in solvent and solvent-free conditions, however, in all cases, the chromeno [3,4-b]xanthone 12a was only obtained in low yields (Table 1, entries [11][12][13][14][15][16]. Attempts to perform the reaction in solvent-free conditions were not advantageous affording compound 12a in only 29-37% yield (Table 1, entries 17 and 18).…”

“…Moreover, the prepared compounds can present enhanced biological properties since they combine the xanthone and chromene nucleus, and the benzochromene and chromone moieties in the same molecules (hybrid drug concept). [15][16][17][18] Results and discussion…”

Microwave‐assisted rapid and efficient synthesis of chromene‐fused pyrrole derivatives through multicomponent reaction and evaluation of antibacterial activity with molecular docking investigation

“…[3,4] Now, the drug improvement with an upgraded and suitable mode of action employs hybrids of different heterocyclic skeletons stands as a dynamic and perception in the production of antibacterial drugs. [7,8] The current literature report reveals that among five and six-membered heterocyclic compounds especially the chemistry of pyrroles, [9,10] along with 2H-chromenes, [11] are quite rewarding after synthetic and medicinal perspective as a result of displaying broad biological actions. [7,8] The current literature report reveals that among five and six-membered heterocyclic compounds especially the chemistry of pyrroles, [9,10] along with 2H-chromenes, [11] are quite rewarding after synthetic and medicinal perspective as a result of displaying broad biological actions.…”

9-Fluoro-2,4,4a,6-tetrahydrospiro[benzo[c]chromene-3,2′-[1,3]dioxolane]

“…In a recent study, several chromene derivatives were evaluated and shown to possess antiproliferative activity against cancer cells (Parthiban et al, 2016). The importance of chromene as a promising pharmacophore with numerous activities such as anticancer, antimicrobial, antiviral, antiinflammatory, antioxidant and antithrombotic was emphasized in a recent review on structurally diversified chromenes (Costa et al, 2016). 1,3-Dioxolane is regarded as a green solvent as it produces stable carbon nanotube dispersions, which leave no residue data reports on electrodes when it evaporates (Moscoso et al, 2014).…”