Biological functions of microRNAs: a review

Huang, Yong; Shen, Xing Jia; Zou, Quan; Wang, Sheng Peng; Tang, Shun Ming; Zhang, Guo Zheng

doi:10.1007/s13105-010-0050-6

Cited by 552 publications

(400 citation statements)

References 75 publications

(82 reference statements)

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“…Pre-miRNA is an intermediate during miRNA biogenesis and how pre-miRNAs are processed by the Dicer complex determines the characteristics of mature miRNA (Huang et al, 2011). Previous research on pre-miRNA and mature miRNA suggested a positive correlation between the expression of pre-miRNAs and their corresponding mature miRNAs, but the regulation mechanism of pre-miRNA and mature miRNA are different (Gan et al, 2013;Schmittgen et al, 2004).…”

Section: Differential Expression Of Pre-mirnas the Same Familymentioning

confidence: 99%

Global analysis of microRNA species in the gall midgeMayetiola destructor

Du¹

2016

2016 International Congress of Entomology

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MicroRNA (miRNA) plays a role in nearly all the biological pathways and therefore may provide opportunities to develop new means to combat the Hessian fly, Mayetiola destructor, a destructive pest of wheat. This study presents a comprehensive analysis of miRNA species via deep-sequencing samples from Hessian fly second instar larvae, pupae and adults. A total of 921 unique miRNA species were identified from approximately 30 million sequence reads. Among the 921 miRNA species, only 22 were conserved among Hessian fly and other insect species, and 242 miRNA species were unique to Hessian fly, the remaining 657 share certain sequence similarities with pre-miRNA genes identified from various insect species. The abundance of the 921 miRNA species based on sequence reads varies greatly among the three analyzed stages, with 20 exclusively expressed in adults, two exclusively expressed in pupae and two exclusively expressed in second instar larvae. For miRNA species expressed in all stages, 722 were with reads lower than 10. The abundance of the remaining 199 miRNA species varied from zero to more than eight-fold differences among different stages. Putative miRNA-encoding genes were analyzed for each miRNA species. A single putative gene was identified for 594 miRNA species. Two putative genes were identified for 138 miRNA species. Three or more putative genes were identified for 86 miRNA species. The three largest families had 14, 23 and 34 putative coding genes, respectively. No gene was identified for the remaining 103 miRNA species. In addition, 1516 putative target genes were identified for 490 miRNA species based on known criteria for miRNA targets. The putative target genes are involved in a wide range of processes from nutrient metabolism to encoding effector proteins. Analysis of the expression patterns of miRNA and pre-miRNA for the miRNA family PC-5p-67443, which contains 91 genes, revealed that miRNA and pre-miRNA were expressed differently in different developmental stages, suggesting that different isogenes are regulated by different mechanisms, or pre-miRNAs had other functions in addition to as an intermediate for miRNA biogenesis. The large set of miRNA species identified here provides a foundation for future research on miRNA functions in Hessian fly and for comparative studies in other species. The differential expression patterns between a pre-miRNA and its encoded mature miRNA in a multigene family is an initial step toward understanding the functional significance of isogenes in dramatically expanded miRNA families.v

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Section: Differential Expression Of Pre-mirnas the Same Familymentioning

confidence: 99%

Global analysis of microRNA species in the gall midgeMayetiola destructor

Du¹

2016

2016 International Congress of Entomology

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“…Recently, ribonucleic acid (RNA) has been studied to elucidate the function of cells [1,2] and it has been applied in biosensors [3,4] and targeting therapies [5,6]. For such studies, the extraction and purification of RNA from cells is required.…”

Section: Introductionmentioning

confidence: 99%

“…It has several features that allow improved adsorption characteristics: (1) it has a high specific surface area and a large pore volume [10,11]; (2) its surface functional groups are easily changed using silica sources containing different functional groups [12,13]; and (3) its pore size, particle size, and particle morphology can be controlled by synthesis condition [14]. For example, Fan et al investigated lysozyme adsorption on MPS materials that had different particle morphologies (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…they required only 10 min to reach equilibrium adsorption) and high capacity (7.3 and 2.3 times, respectively) adsorption of lysozymes compared with the stacking rodlike and large spherical MPS materials. Moreover, Fuertes et al tuned the pore size of MPS from 3 to 9 nm by adding a swelling agent (1,3, and N, N-dimethylhexadecylamine), and they found that its hemoglobin adsorption capacity (2080 mg/g) was greater with this larger pore size [16].…”

Section: Introductionmentioning

confidence: 99%

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Elucidating the effect of different amino-functionalized spherical mesoporous silica characteristics on ribonucleic acid selectivity and adsorption capacity

Hikosaka

Nagata

Tomita

et al. 2018

Journal of Asian Ceramic Societies

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“…12 Primarily, miRNAs function as crucial factors in diverse regulation pathways, 13 including tumorigenesis, cell differentiation, proliferation, and apoptosis. Accumulating evidence indicates that miRNAs can act in human carcinogenesis as novel types of tumor suppressors or oncogenes.…”

Section: Introductionmentioning

confidence: 99%

Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer

Zhang

Gao

et al. 2017

Tumour Biol.

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The pathogenesis of colorectal cancer remains poorly understood. Here, we show that coactivator-associated arginine methyltransferase 1 is frequently upregulated in colorectal cancer tissues and promotes cell growth in vitro and in vivo. Using bioinformatics-based prediction and luciferase reporter system, we found that coactivatorassociated arginine methyltransferase 1 is post-transcriptionally targeted by microRNA-195-5p in colorectal cancer. Ectopic expression of microRNA-195-5p led to the suppression of the coactivator-associated arginine methyltransferase 1 3′-untranslated regions activity and downregulation of the endogenous coactivator-associated arginine methyltransferase 1 protein in colorectal cancer cells. Expression analysis verified that microRNA-195-5p was markedly downregulated in human colorectal cancer tissues, which was negatively correlated with the elevated levels of coactivator-associated arginine methyltransferase 1 protein. Enhanced levels of microRNA-195-5p in colorectal cancer cells resulted in a sharp reduction of cell proliferative and colony-formative capacities in vitro. Remarkably, restoration of coactivator-associated arginine methyltransferase 1 in microRNA-195-5p-transfected colorectal cancer cells partially abrogated the inhibition of cell proliferation and colony formation mediated through microRNA-195-5p. These data confirm that microRNA-195-5p might function as an anti-tumor microRNA in colorectal cancer exerting critical control over coactivator-associated arginine methyltransferase 1 expression. The newly identified microRNA-195-5p/coactivator-associated arginine methyltransferase 1 axis may act as a novel promising therapeutic target for colorectal cancer treatment.

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Biological functions of microRNAs: a review

Cited by 552 publications

References 75 publications

Global analysis of microRNA species in the gall midgeMayetiola destructor

Global analysis of microRNA species in the gall midgeMayetiola destructor

Elucidating the effect of different amino-functionalized spherical mesoporous silica characteristics on ribonucleic acid selectivity and adsorption capacity

Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer

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