Biological Function of HYOU1 in Tumors and Other Diseases

Abstract

Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.

Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells

“…The ER stress response is largely triggered by the accumulation of unfolded proteins in the ER and is meant to restore ER homeostasis ( 54 , 55 ), but the prolonged exposure to ER stress can trigger apoptosis by ATF4 induction of the pro-apoptotic transcription factor CHOP ( 54 ), which we found uniquely upregulated by P. falciparum -iRBCLs. Although these are pro-apoptotic genes, P. falciparum -iRBCLs also uniquely upregulate DEGs proposed to be anti-apoptotic, like BDNF ( 56 ), HMOX1 ( 57 ), HERPUD1 ( 58 ), and HYOU1 ( 59 ). Since iRBCLs do not induce apoptosis in HBMECs, these results suggest that anti-apoptotic signals dominate the live/dead HBMEC response.…”

Comparative analyses of the N-glycoproteomes in HCT116 cancer cells and their non-tumorigenic DNMT1/3b double knockout (DKO1) cells and insight into the Mannose-6-phosphate pathway

“…Among those proteins, there was no paucimannose detected in 7 proteins in HCT116, while a significant amount of paucimannose was detected in these proteins in DKO1 cells. The most interesting paucimannose change is in Hypoxia up-regulated protein 1 (Q9Y4L1|HYOU1) 30 . 355 PSM out of total 2659 N-glyco PSM (13.4%) are identified as paucimannosidic N-glycosylation in the HYOU1 of DKO1 cells.…”

Proteomics Approach Highlights Early Changes in Human Fibroblasts-Pancreatic Ductal Adenocarcinoma Cells Crosstalk

“…Specifically, HYOU1 is an endoplasmic reticulum chaperone protein known to be induced by a variety of stress conditions including hypoxia, glucose deficiency, reducing agents and tunicamycin. HYOU1 inhibits apoptosis, maintains calcium homeostasis, and exhibits cytoprotective effects by preventing endoplasmic reticulum stress [ 41 ]. GRB2 is a key molecule in intracellular signal transduction, linking activated cell surface receptors to downstream targets by binding to specific phosphotyrosine-containing and proline-rich sequence motifs.…”