Biological Factors of Importance for Bone Integration of Implanted Devices

Albrektsson, Tomas

doi:10.1007/978-1-4471-1811-4_2

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…During the healing phase, these gaps are filled with callus tissue which may mature in different directions, i.e. by bony healing or osseointegration, where there is no fibrous lining between the implant and the bone, or by soft tissue encapsulation with formation of synovial-like membrane (Albrektsson, 1990). In osseointegration of the prosthesis the interface can resist shearing as well as tensile loads whereas the fibrous tissue interface can withstand compressive and, to lesser extent, shear loads, but fails with tensile loads.…”

Section: Future Perspectivesmentioning

confidence: 99%

Evidence Linking Elevated Oxidative Stress and Aseptic Loosening of Hip Arthroplasty

Kinov¹,

Tivchev²

2012

Recent Advances in Arthroplasty

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Section: Future Perspectivesmentioning

confidence: 99%

Evidence Linking Elevated Oxidative Stress and Aseptic Loosening of Hip Arthroplasty

Kinov¹,

Tivchev²

2012

Recent Advances in Arthroplasty

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Orthopedics, Prosthesis Fixation for

Prendergast¹

2006

Encyclopedia of Medical Devices and Instrumentation

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Methods of fixation of orthopedic implants include (1) use of a grouting polymer (polymethylmethacrylate) to interlock the prosthesis to the bone and (2) osseointegration, which relies on ingrowth of the bone into the implant surface. Osseointegration takes several forms involving a structured surface (wire mesh, beads, etc.), sometimes coupled with an osteoconductive layer (e.g., a hydroxyapatite coating). Both approaches are in wide use in all kinds of joint replacement. In some cases, one side of a joint replacement prosthesis is fixated with cement and the other by osseointegration; such replacements are called hybrid replacements. Both approaches are undergoing continuous development: Fixation with bone cement is improving with each new generation of cementing techniques, and improvements may include bioactive cements in the future; osseointegration is undergoing improvements of osteoconductive coatings, including the addition of growth factors and a better understanding of the relationship between implant stability and bone ingrowth. An overview is given of fixation used in the main orthopedic implant categories.

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