Evidence Linking Elevated Oxidative Stress and Aseptic Loosening of Hip Arthroplasty

Kinov, Plamen; Tivchev, Peter

doi:10.5772/25826

Cited by 6 publications

(2 citation statements)

References 99 publications

(115 reference statements)

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“…As a component of the most commonly used metal-on-polymer bearing couple for an artificial joint, − ultrahigh molecular weight polyethylene (UHMWPE) is a polymer material with low friction, fine biocompatibility, and chemical stability. − However, pure UHMWPE suffers from severe material degradation and damage under sliding conditions, generating wear particles in the process that can be phagocytosed by macrophages, , leading to the release of bone-resorptive factors, causing osseous dissolution and aseptic loosening. , As a result, the lifetime of such artificial joint is only 15–20 years. , Considering the fact that more and more young patients are suffering osteoarthritis (OA), extending the lifetime of artificial joints is of imperative, practical, and economic significance.…”

Section: Introductionmentioning

confidence: 99%

Hydration Lubrication Applicable to Artificial Joints through Polyelectrolyte-Embedded Modification on UHMWPE

Zhang

2022

ACS Appl. Polym. Mater.

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Hydration lubrication by the hydrated surface-grafted macromolecules covering the joint cartilage is crucial for the proper functioning of natural synovial joints. However, when considering artificial replacements, similar surface-grafted polymers on artificial materials are usually insufficient for the long-term lubrication due to lack of stability and durability. In this work, an overall material modification through embedding polyelectrolyte brushes was performed for prolonged lifetime. Method-wise, hydrophilic monomer 3-sulfopropyl methacrylate potassium salt (SPMK) was grafted onto ultrahigh molecular weight polyethylene (UHMWPE) powders through photoinduced radical graft polymerization, followed by hot-press forming of the modified powders to afford homogeneous modified material. Trials revealed significantly increased surface wettability and negative charge density, giving rise to strong hydration lubrication that led to a stable and low friction coefficient of 0.009, and an ultralow wear rate of 9.1 × 10–8 mm3 (N m)−1 under physiological conditions, which could be consistently maintained even after the surface was sheared off with polishing equipment. This overall material modification on UHMWPE through polyelectrolyte embedment, applied to obtain long-lasting, highly lubricated materials, therefore presents a promising method for the preparation of artificial joints.

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Section: Introductionmentioning

confidence: 99%

Hydration Lubrication Applicable to Artificial Joints through Polyelectrolyte-Embedded Modification on UHMWPE

Zhang

2022

ACS Appl. Polym. Mater.

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“…In particular, free radicals and Reactive oxygen species (ROS), comprising superoxide ions (O 2 À ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OHÁ), and nitrogen oxide (NO•), play a significant role in chronic inflammation diseases, which inhibit the differentiation of osteoblasts (cells which synthesize the bone); damage proteins, lipids, and DNA; and accelerate osteoporosis. Consequently, the typical lifetime of an implant is 15-20 years, which implies repeated surgery for young patients (Manivasagam et al 2010;Kinov and Tivchev 2012;Catauro et al 2016). To solve such problems, it is important to finely design the chemical structure of these biomaterials.…”

Section: Introductionmentioning

confidence: 99%